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Published in: Health and Quality of Life Outcomes 1/2020

01-12-2020 | Affective Disorder | Research

Evaluating prevalence of depression, anxiety and hopelessness in patients with Vitiligo on an Iranian population

Authors: Nasrin Hamidizadeh, Sara Ranjbar, Ahmad Ghanizadeh, Mohammad Mahdi Parvizi, Peyman Jafari, Farhad Handjani

Published in: Health and Quality of Life Outcomes | Issue 1/2020

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Abstract

Introduction

Vitiligo is caused by partial or complete destruction of melanocytes in the affected skin area and influences the patient’s quality of life. Besides physical involvement, vitiligo patients experience a high level of stress. Depression and Anxiety are common psychiatric disorders in vitiligo patients.

Aim

This study, as the first study, evaluates hopelessness, anxiety, depression and general health of vitiligo patients in comparison with normal controls in an Iranian population.

Method

Hundred patients with vitiligo and hundred healthy controls were examined. General health, depression, hopelessness and anxiety were evaluated based on general health questionnaire. Anxiety, depression and hopelessness levels were analyzed using Chi–Square, and the mean value of general health was evaluated through t-test.

Results

The results showed that anxiety and hopelessness levels were significantly higher in vitiligo patients than those who are in healthy controls. This significant difference refers to high levels of anxiety and hopelessness among women with vitiligo.
It was also found that the single patients were more anxious, hopeless and depressive, while the married patients were only more anxious and hopeless than those who are in the control group, respectively.
General health of patients was significantly worse than in healthy controls. The low level of general health in patients was related to poorer level of general health among women with vitiligo.

Conclusion

It seems that women with vitiligo are more mentally stressed than men with vitiligo. Both singles and married vitiligo patients suffer from anxiety and hopelessness.
Literature
1.
go back to reference Tarle RG, Nascimento LM, Mira MT, Castro CC. Vitiligo--part 1. An Bras Dermatol. 2014;89(3):461–70 Epub 2014/06/18. PubMed PMID: 24937821; PubMed Central PMCID: PMC4056705.CrossRef Tarle RG, Nascimento LM, Mira MT, Castro CC. Vitiligo--part 1. An Bras Dermatol. 2014;89(3):461–70 Epub 2014/06/18. PubMed PMID: 24937821; PubMed Central PMCID: PMC4056705.CrossRef
3.
go back to reference Le Poole IC, van den Wijngaard RM, Westerhof W, Dutrieux RP, Das PK. Presence or absence of melanocytes in vitiligo lesions: an immunohistochemical investigation. J Invest Dermatol. 1993;100(6):816–22 Epub 1993/06/01. PubMed PMID: 7684427.CrossRef Le Poole IC, van den Wijngaard RM, Westerhof W, Dutrieux RP, Das PK. Presence or absence of melanocytes in vitiligo lesions: an immunohistochemical investigation. J Invest Dermatol. 1993;100(6):816–22 Epub 1993/06/01. PubMed PMID: 7684427.CrossRef
5.
go back to reference Silverberg NB. The epidemiology of vitiligo. Curr Derm Rep. 2015;4:36–43.CrossRef Silverberg NB. The epidemiology of vitiligo. Curr Derm Rep. 2015;4:36–43.CrossRef
6.
go back to reference Mosher DB, Fitzpatrick TB, Ortonne JP, Hori Y. Disorders of pigmentation. In: Fitzpatrick TB, Eisen AZ, Wolff K, Freedberg IM, Austen KF, editors. Dermatology in general medicine. New York: McGraw-Hill Book Co.; 1987. p. 794–876. Mosher DB, Fitzpatrick TB, Ortonne JP, Hori Y. Disorders of pigmentation. In: Fitzpatrick TB, Eisen AZ, Wolff K, Freedberg IM, Austen KF, editors. Dermatology in general medicine. New York: McGraw-Hill Book Co.; 1987. p. 794–876.
7.
go back to reference Masini C, AD Vitiligo. 4th ed. In: Williams H. Birgby M, Diepgen T. Herxheimer A. Naldi L. Rzany B. editors. Evidence-based dermatology. BMJ Publishing Group. 2003. Masini C, AD Vitiligo. 4th ed. In: Williams H. Birgby M, Diepgen T. Herxheimer A. Naldi L. Rzany B. editors. Evidence-based dermatology. BMJ Publishing Group. 2003.
8.
go back to reference Majumder PP, Nordlund JJ, Nath SK. Pattern of familial aggregation of vitiligo. Arch Dermatol. 1993;129(8):994–8 Epub 1993/08/01. PubMed PMID: 8352624.CrossRef Majumder PP, Nordlund JJ, Nath SK. Pattern of familial aggregation of vitiligo. Arch Dermatol. 1993;129(8):994–8 Epub 1993/08/01. PubMed PMID: 8352624.CrossRef
10.
go back to reference Hahn SK, Nordlund JJ. Vitiligo. Oxford: Blackwell Science; 2000. p. 1–306.CrossRef Hahn SK, Nordlund JJ. Vitiligo. Oxford: Blackwell Science; 2000. p. 1–306.CrossRef
11.
go back to reference Braun-Falco O, Plewig G, Wolf HH. Dermatologie und Venerologie, 4. Aufl., Depigmentierungen. Berlin, Heidelberg, New York: Springer; 1996. p. 931ff. Braun-Falco O, Plewig G, Wolf HH. Dermatologie und Venerologie, 4. Aufl., Depigmentierungen. Berlin, Heidelberg, New York: Springer; 1996. p. 931ff.
12.
go back to reference De Gruyter W. Pschyrembel Klinisches Wörterbuch (259., neu bearbeitete Auflage). Berlin: Walter de Gruyter Gmbh & Co. KG; 2002. De Gruyter W. Pschyrembel Klinisches Wörterbuch (259., neu bearbeitete Auflage). Berlin: Walter de Gruyter Gmbh & Co. KG; 2002.
13.
go back to reference Porter J, Beuf AH, Nordlund JJ, Lerner AB. Psychological reaction to chronic skin disorders: a study of patients with vitiligo. Gen Hosp Psychiatry. 1979;1(1):73–7 Epub 1979/04/01. PubMed PMID: 499777.CrossRef Porter J, Beuf AH, Nordlund JJ, Lerner AB. Psychological reaction to chronic skin disorders: a study of patients with vitiligo. Gen Hosp Psychiatry. 1979;1(1):73–7 Epub 1979/04/01. PubMed PMID: 499777.CrossRef
14.
go back to reference Porter J, Beuf AH, Lerner A, Nordlund J. Response to cosmetic disfigurement: patients with vitiligo. Cutis. 1987;39(6):493–4 Epub 1987/06/01. PubMed PMID: 3608575.PubMed Porter J, Beuf AH, Lerner A, Nordlund J. Response to cosmetic disfigurement: patients with vitiligo. Cutis. 1987;39(6):493–4 Epub 1987/06/01. PubMed PMID: 3608575.PubMed
15.
go back to reference Porter JR, Beuf AH, Lerner AB, Nordlund JJ. The effect of vitiligo on sexual relationships. J Am Acad Dermatol. 1990;22(2 Pt 1):221–2 Epub 1990/02/01. PubMed PMID: 2312803.CrossRef Porter JR, Beuf AH, Lerner AB, Nordlund JJ. The effect of vitiligo on sexual relationships. J Am Acad Dermatol. 1990;22(2 Pt 1):221–2 Epub 1990/02/01. PubMed PMID: 2312803.CrossRef
19.
go back to reference Shenefelt PD. Psychological interventions in the management of common skin conditions. Psychol Res Behav Manag. 2010;3:51–63 Epub 2010/01/01. PubMed PMID: 22110329; PubMed Central PMCID: PMC3218765.CrossRef Shenefelt PD. Psychological interventions in the management of common skin conditions. Psychol Res Behav Manag. 2010;3:51–63 Epub 2010/01/01. PubMed PMID: 22110329; PubMed Central PMCID: PMC3218765.CrossRef
21.
go back to reference Goldberg DP, Hillier VF. A scaled version of the general health questionnaire. Psychol Med. 1979;9(1):139–45 PubMed PMID: 424481.CrossRef Goldberg DP, Hillier VF. A scaled version of the general health questionnaire. Psychol Med. 1979;9(1):139–45 PubMed PMID: 424481.CrossRef
22.
go back to reference Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J. An inventory for measuring depression. Arch Gen Psychiatry. 1961;4:561–71 PubMed PMID: 13688369.CrossRef Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J. An inventory for measuring depression. Arch Gen Psychiatry. 1961;4:561–71 PubMed PMID: 13688369.CrossRef
23.
go back to reference Beck AT, Weissman A, Lester D, Trexler L. The measurement of pessimism: the hopelessness scale. J Consult Clin Psychol. 1974;42(6):861–5 PubMed PMID: 4436473.CrossRef Beck AT, Weissman A, Lester D, Trexler L. The measurement of pessimism: the hopelessness scale. J Consult Clin Psychol. 1974;42(6):861–5 PubMed PMID: 4436473.CrossRef
24.
go back to reference Beck AT, Epstein N, Brown G, Steer RA. An inventory for measuring clinical anxiety: psychometric properties. J Consult Clin Psychol. 1988;56(6):893–7 PubMed PMID: 3204199.CrossRef Beck AT, Epstein N, Brown G, Steer RA. An inventory for measuring clinical anxiety: psychometric properties. J Consult Clin Psychol. 1988;56(6):893–7 PubMed PMID: 3204199.CrossRef
25.
go back to reference Mattoo SK, Handa S, Kaur I, Gupta N, Malhotra R. Psychiatric morbidity in vitiligo and psoriasis: a comparative study from India. J Dermatol. 2001;28(8):424–32 PubMed PMID: 11560159.CrossRef Mattoo SK, Handa S, Kaur I, Gupta N, Malhotra R. Psychiatric morbidity in vitiligo and psoriasis: a comparative study from India. J Dermatol. 2001;28(8):424–32 PubMed PMID: 11560159.CrossRef
26.
go back to reference Mattoo SK, Handa S, Kaur I, Gupta N, Malhotra R. Psychiatric morbidity in vitiligo: prevalence and correlates in India. J Eur Acad Dermatol Venereol. 2002;16(6):573–8 PubMed PMID: 12482039.CrossRef Mattoo SK, Handa S, Kaur I, Gupta N, Malhotra R. Psychiatric morbidity in vitiligo: prevalence and correlates in India. J Eur Acad Dermatol Venereol. 2002;16(6):573–8 PubMed PMID: 12482039.CrossRef
27.
go back to reference Kruger C, Smythe JW, Spencer JD, Hasse S, Panske A, Chiuchiarelli G, et al. Significant immediate and long-term improvement in quality of life and disease coping in patients with vitiligo after group climatotherapy at the Dead Sea. Acta Derm Venereol. 2011;91(2):152–9. https://doi.org/10.2340/00015555-1037 PubMed PMID: 21240455.CrossRefPubMed Kruger C, Smythe JW, Spencer JD, Hasse S, Panske A, Chiuchiarelli G, et al. Significant immediate and long-term improvement in quality of life and disease coping in patients with vitiligo after group climatotherapy at the Dead Sea. Acta Derm Venereol. 2011;91(2):152–9. https://​doi.​org/​10.​2340/​00015555-1037 PubMed PMID: 21240455.CrossRefPubMed
28.
go back to reference Taghavi SMR. Validity and reliability of the general health questionnaire (GHQ-28) in college students of Shiraz University. J Psycho. 2002;4(20):381–98. Taghavi SMR. Validity and reliability of the general health questionnaire (GHQ-28) in college students of Shiraz University. J Psycho. 2002;4(20):381–98.
29.
go back to reference Goudarzi MA. The study of reliability and validity of Beck hopelessness scale in a group of Shiraz University students. J Soc Sci Hum Shiraz Univ. 2002;18.2(36):27–39. Goudarzi MA. The study of reliability and validity of Beck hopelessness scale in a group of Shiraz University students. J Soc Sci Hum Shiraz Univ. 2002;18.2(36):27–39.
30.
go back to reference Kaviani H, Seyfourian H, Sharifi V, Ebrahimkhani N. Reliability and validity of Anxiety and Depression Hospital Scales (HADS): Iranian patients with anxiety and depression disorders. Tehran Univ Med J. 2009;67(5):379–85. Kaviani H, Seyfourian H, Sharifi V, Ebrahimkhani N. Reliability and validity of Anxiety and Depression Hospital Scales (HADS): Iranian patients with anxiety and depression disorders. Tehran Univ Med J. 2009;67(5):379–85.
31.
go back to reference Amer AA, Gao XH. Quality of life in patients with vitiligo: an analysis of the dermatology life quality index outcome over the past two decades. Int J Dermatol. 2016;55(6):608–14.CrossRef Amer AA, Gao XH. Quality of life in patients with vitiligo: an analysis of the dermatology life quality index outcome over the past two decades. Int J Dermatol. 2016;55(6):608–14.CrossRef
33.
go back to reference Dolatshahi M, Ghazi P, Feizy V, Hemami MR. Life quality assessment among patients with vitiligo: comparison of married and single patients in Iran. Indian J Dermatol Venereol Leprol. 2008;74(6):700 Epub 2009/01/31. PubMed PMID: 19177700.PubMed Dolatshahi M, Ghazi P, Feizy V, Hemami MR. Life quality assessment among patients with vitiligo: comparison of married and single patients in Iran. Indian J Dermatol Venereol Leprol. 2008;74(6):700 Epub 2009/01/31. PubMed PMID: 19177700.PubMed
35.
go back to reference Mashayekhi V, Javidi Z, Kiafar B, Manteghi AA, Saadatian V, Esmaeili HA, et al. Quality of life in patients with vitiligo: a descriptive study on 83 patients attending a PUVA therapy unit in Imam Reza Hospital, Mashad. Indian J Dermatol Venereol Leprol. 2010;76(5):592. https://doi.org/10.4103/0378-6323.69097 Epub 2010/09/10. PubMed PMID: 20827019.CrossRefPubMed Mashayekhi V, Javidi Z, Kiafar B, Manteghi AA, Saadatian V, Esmaeili HA, et al. Quality of life in patients with vitiligo: a descriptive study on 83 patients attending a PUVA therapy unit in Imam Reza Hospital, Mashad. Indian J Dermatol Venereol Leprol. 2010;76(5):592. https://​doi.​org/​10.​4103/​0378-6323.​69097 Epub 2010/09/10. PubMed PMID: 20827019.CrossRefPubMed
37.
go back to reference Borimnejad L, Parsa Yekta Z, Nikbakht-Nasrabadi A, Firooz A. Quality of life with vitiligo: comparison of male and female muslim patients in Iran. Gender Med. 2006;3(2):124–30 Epub 2006/07/25. PubMed PMID: 16860271.CrossRef Borimnejad L, Parsa Yekta Z, Nikbakht-Nasrabadi A, Firooz A. Quality of life with vitiligo: comparison of male and female muslim patients in Iran. Gender Med. 2006;3(2):124–30 Epub 2006/07/25. PubMed PMID: 16860271.CrossRef
38.
go back to reference Al-Harbi M. Prevalence of depression in vitiligo patients. Skinmed. 2013;11(6):327–30 Epub 2014/02/13. PubMed PMID: 24517036.PubMed Al-Harbi M. Prevalence of depression in vitiligo patients. Skinmed. 2013;11(6):327–30 Epub 2014/02/13. PubMed PMID: 24517036.PubMed
40.
go back to reference Ahmed I, Ahmed S, Nasreen S. Frequency and pattern of psychiatric disorders in patients with vitiligo. J Ayub Med Coll Abbottabad. 2007;19(3):19–21 Epub 2008/05/01. PubMed PMID: 18444584.PubMed Ahmed I, Ahmed S, Nasreen S. Frequency and pattern of psychiatric disorders in patients with vitiligo. J Ayub Med Coll Abbottabad. 2007;19(3):19–21 Epub 2008/05/01. PubMed PMID: 18444584.PubMed
42.
go back to reference Ongenae K, Van Geel N, De Schepper S, Naeyaert JM. Effect of vitiligo on self-reported health-related quality of life. Br J Dermatol. 2005;152(6):1165–72.CrossRef Ongenae K, Van Geel N, De Schepper S, Naeyaert JM. Effect of vitiligo on self-reported health-related quality of life. Br J Dermatol. 2005;152(6):1165–72.CrossRef
43.
go back to reference Catucci Boza J, Giongo N, Machado P, Horn R, Fabbrin A, Cestari T. Quality of life impairment in children and adults with Vitiligo: a cross-sectional study based on dermatology-specific and disease-specific quality of life instruments. Dermatology. 2016;232(5):619–25.CrossRef Catucci Boza J, Giongo N, Machado P, Horn R, Fabbrin A, Cestari T. Quality of life impairment in children and adults with Vitiligo: a cross-sectional study based on dermatology-specific and disease-specific quality of life instruments. Dermatology. 2016;232(5):619–25.CrossRef
44.
go back to reference Sarhan D, Mohammed GF, Gomaa AH, Eyada MM. Female genital dialogues: female genital self-image, sexual dysfunction, and quality of life in patients with Vitiligo with and without genital affection. J Sex Marital Therapy. 2016;42(3):267–76.CrossRef Sarhan D, Mohammed GF, Gomaa AH, Eyada MM. Female genital dialogues: female genital self-image, sexual dysfunction, and quality of life in patients with Vitiligo with and without genital affection. J Sex Marital Therapy. 2016;42(3):267–76.CrossRef
47.
go back to reference Silvan M. The psychological aspects of vitiligo. Cutis. 2004;73(3):163–7 Epub 2004/04/13. PubMed PMID: 15074343.PubMed Silvan M. The psychological aspects of vitiligo. Cutis. 2004;73(3):163–7 Epub 2004/04/13. PubMed PMID: 15074343.PubMed
48.
go back to reference Papadopoulos L, Bor R, Legg C. Coping with the disfiguring effects of vitiligo: a preliminary investigation into the effects of cognitive-behavioural therapy. Brit J Med Psychol. 1999;72(Pt 3):385–96 Epub 1999/10/19. PubMed PMID: 10524722.CrossRef Papadopoulos L, Bor R, Legg C. Coping with the disfiguring effects of vitiligo: a preliminary investigation into the effects of cognitive-behavioural therapy. Brit J Med Psychol. 1999;72(Pt 3):385–96 Epub 1999/10/19. PubMed PMID: 10524722.CrossRef
49.
go back to reference Gupta MA, Gupta AK. Psychiatric and psychological co-morbidity in patients with dermatologic disorders: epidemiology and management. Am J Clin Dermatol. 2003;4(12):833–42.CrossRef Gupta MA, Gupta AK. Psychiatric and psychological co-morbidity in patients with dermatologic disorders: epidemiology and management. Am J Clin Dermatol. 2003;4(12):833–42.CrossRef
50.
go back to reference Parsad D, Pandhi R, Dogra S, Kanwar AJ, Kumar B. Dermatology life quality index score in vitiligo and its impact on the treatment outcome. Br J Dermatol. 2003;148(2):373–4 Epub 2003/02/18. PubMed PMID: 12588405.CrossRef Parsad D, Pandhi R, Dogra S, Kanwar AJ, Kumar B. Dermatology life quality index score in vitiligo and its impact on the treatment outcome. Br J Dermatol. 2003;148(2):373–4 Epub 2003/02/18. PubMed PMID: 12588405.CrossRef
Metadata
Title
Evaluating prevalence of depression, anxiety and hopelessness in patients with Vitiligo on an Iranian population
Authors
Nasrin Hamidizadeh
Sara Ranjbar
Ahmad Ghanizadeh
Mohammad Mahdi Parvizi
Peyman Jafari
Farhad Handjani
Publication date
01-12-2020
Publisher
BioMed Central
Published in
Health and Quality of Life Outcomes / Issue 1/2020
Electronic ISSN: 1477-7525
DOI
https://doi.org/10.1186/s12955-020-1278-7

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