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Open Access 01-12-2020 | Ulcerative Colitis | Research

Anatabine ameliorates intestinal inflammation and reduces the production of pro-inflammatory factors in a dextran sulfate sodium mouse model of colitis

Authors: Pedro A. Ruiz Castro, Ulrike Kogel, Giuseppe Lo Sasso, Blaine W. Phillips, Alain Sewer, Bjorn Titz, Llenalia Garcia, Athanasios Kondylis, Emmanuel Guedj, Dariusz Peric, David Bornand, Remi Dulize, Celine Merg, Maica Corciulo, Nikolai V. Ivanov, Manuel C. Peitsch, Julia Hoeng

Published in: Journal of Inflammation | Issue 1/2020

Abstract

Background

Inflammatory bowel disease (IBD) is the collective term for chronic immune-mediated diseases of unknown, multifactorial etiology, arising from the interplay between genetic and environmental factors and including two main disease manifestations: ulcerative colitis (UC) and Crohn’s disease. In the last few decades, naturally occurring alkaloids have gained interest because of their substantial anti-inflammatory effects in several animal models of disease. Studies on mouse models of IBD have demonstrated the anti-inflammatory action of the main tobacco alkaloid, nicotine. In addition, anatabine, a minor tobacco alkaloid also present in peppers, tomato, and eggplant presents anti-inflammatory properties in vivo and in vitro. In this study, we aimed to evaluate the anti-inflammatory properties of nicotine and anatabine in a dextran sulfate sodium (DSS) mouse model of UC.

Results

Oral administration of anatabine, but not nicotine, reduced the clinical symptoms of DSS-induced colitis. The result of gene expression analysis suggested that anatabine had a restorative effect on global DSS-induced gene expression profiles, while nicotine only had limited effects. Accordingly, MAP findings revealed that anatabine reduced the colonic abundance of DSS-associated cytokines and increased IL-10 abundance.

Conclusions

Our results support the amelioration of inflammatory effects by anatabine in the DSS mouse model of UC, and suggest that anatabine constitutes a promising therapeutic agent for IBD treatment.

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Title: Anatabine ameliorates intestinal inflammation and reduces the production of pro-inflammatory factors in a dextran sulfate sodium mouse model of colitis
Authors: Pedro A. Ruiz Castro
Ulrike Kogel
Giuseppe Lo Sasso
Blaine W. Phillips
Alain Sewer
Bjorn Titz
Llenalia Garcia
Athanasios Kondylis
Emmanuel Guedj
Dariusz Peric
David Bornand
Remi Dulize
Celine Merg
Maica Corciulo
Nikolai V. Ivanov
Manuel C. Peitsch
Julia Hoeng
Publication date: 01-12-2020
Publisher: BioMed Central
Keywords: Ulcerative Colitis
Chronic Inflammatory Bowel Disease
Alkaloids
Alkaloids
Published in: Journal of Inflammation / Issue 1/2020
Electronic ISSN: 1476-9255
DOI: https://doi.org/10.1186/s12950-020-00260-6

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