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Journal of Inflammation
Published in: Journal of Inflammation 1/2014

Open Access 01-12-2014 | Research

Upregulation of ICAM-1 in diabetic rats after transient forebrain ischemia and reperfusion injury

Authors: Li Jing, Jian-Gang Wang, Jian-Zhong Zhang, Cai-Xia Cao, Yue Chang, Jian-Da Dong, Feng-Ying Guo, P Andy Li

Published in: Journal of Inflammation | Issue 1/2014

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Abstract

Background

Hyperglycemia exacerbates brain damage caused by cerebral ischemia. Neuroinflammation may play a role in mediating such enhanced damage. The objectives of this study were to examine the mRNA and protein levels and cell type distribution of ICAM-1 after cerebral ischemia in normo-and diabetic hyperglycemic rats.

Results

Compared to normoglycemic ischemia animals, diabetes aggravated neuronal death, decreased Nissl body staining, and increased ICAM-1 mRNA and protein levels in the frontal cortex. The increased ICAM-1 was located not only in vascular endothelial cells but also in cortical neurons.

Conclusions

Our results suggest that exacerbated neuro-inflammation in the brain may mediate the detrimental effects of diabetes on the ischemic brain.
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Metadata
Title
Upregulation of ICAM-1 in diabetic rats after transient forebrain ischemia and reperfusion injury
Authors
Li Jing
Jian-Gang Wang
Jian-Zhong Zhang
Cai-Xia Cao
Yue Chang
Jian-Da Dong
Feng-Ying Guo
P Andy Li
Publication date
01-12-2014
Publisher
BioMed Central
Published in
Journal of Inflammation / Issue 1/2014
Electronic ISSN: 1476-9255
DOI
https://doi.org/10.1186/s12950-014-0035-2

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