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Molecular Cancer
Published in: Molecular Cancer 1/2016

Open Access 01-12-2016 | Review

Long noncoding RNAs in cancer: mechanisms of action and technological advancements

Authors: Nenad Bartonicek, Jesper L. V. Maag, Marcel E. Dinger

Published in: Molecular Cancer | Issue 1/2016

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Abstract

The previous decade has seen long non-coding RNAs (lncRNAs) rise from obscurity to being defined as a category of genetic elements, leaving its mark on the field of cancer biology. With the current number of curated lncRNAs increasing by 10,000 in the last five years, the field is moving from annotation of lncRNA expression in various tumours to understanding their importance in the key cancer signalling networks and characteristic behaviours. Here, we summarize the previously identified as well as recently discovered mechanisms of lncRNA function and their roles in the hallmarks of cancer. Furthermore, we identify novel technologies for investigation of lncRNA properties and their function in carcinogenesis, which will be important for their translation to the clinic as novel biomarkers and therapeutic targets.
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Metadata
Title
Long noncoding RNAs in cancer: mechanisms of action and technological advancements
Authors
Nenad Bartonicek
Jesper L. V. Maag
Marcel E. Dinger
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Molecular Cancer / Issue 1/2016
Electronic ISSN: 1476-4598
DOI
https://doi.org/10.1186/s12943-016-0530-6

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