Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

ACC 2024 Congress

Catch up on all the top stories and latest evidence in cardiology research with our ACC 2024 Congress hub page.
ADVANCED SEARCH
Log in
Top
Malaria Journal
Published in: Malaria Journal 1/2017

Open Access 01-12-2017 | Review

Systematic review on traditional medicinal plants used for the treatment of malaria in Ethiopia: trends and perspectives

Authors: Getachew Alebie, Befikadu Urga, Amha Worku

Published in: Malaria Journal | Issue 1/2017

Login to get access

Abstract

Background

Ethiopia is endowed with abundant medicinal plant resources and traditional medicinal practices. However, available research evidence on indigenous anti-malarial plants is highly fragmented in the country. The present systematic review attempted to explore, synthesize and compile ethno-medicinal research evidence on anti-malarial medicinal plants in Ethiopia.

Methods

A systematic web search analysis and review was conducted on research literature pertaining to medicinal plants used for traditional malaria treatment in Ethiopia. Data were collected from a total of 82 Ethiopian studies meeting specific inclusion criteria including published research articles and unpublished thesis reports. SPSS Version 16 was used to summarize relevant ethno-botanical/medicinal information using descriptive statistics, frequency, percentage, tables, and bar graphs.

Results

A total of 200 different plant species (from 71 families) used for traditional malaria treatment were identified in different parts of Ethiopia. Distribution and usage pattern of anti-malarial plants showed substantial variability across different geographic settings. A higher diversity of anti-malarial plants was reported from western and southwestern parts of the country. Analysis of ethno-medicinal recipes indicated that mainly fresh leaves were used for preparation of remedies. Decoction, concoction and eating/chewing were found to be the most frequently employed herbal remedy preparation methods. Notably, anti-malarial herbal remedies were administered by oral route. Information on potential side effects of anti-malarial herbal preparations was patchy. However, some anti-malarial plants were reported to have potentially serious side effects using different local antidotes and some specific contra-indications.

Conclusion

The study highlighted a rich diversity of indigenous anti-malarial medicinal plants with equally divergent herbal remedy preparation and use pattern in Ethiopia. Baseline information gaps were observed in key geographic settings. Likewise, herbal remedy toxicity risks and countermeasures generally entailed more exhaustive investigation. Experimental research and advanced chemical analysis are also required to validate the therapeutic potential of anti-malarial compounds from promising plant species.
Appendix
Available only for authorised users
Literature
1.
WHO. World malaria report. Geneva: World Health Organization; 2015.
2.
WHO. World Malaria Report. Geneva: World Health Organization; 2014.
3.
4.
FMOH. National strategic plan for malaria prevention, control and elimination in Ethiopia: 2014–2020. Addis Ababa: Federal Ministry of Health of Ethiopia; 2014.
5.
6.
Ashley EA, Dhorda M, Fairhurst RM, Amaratunga C, Lim P, Suon S, et al. Spread of artemisin in resistance in Plasmodium falciparum malaria. N Engl J Med. 2014;371:411–23.PubMedPubMedCentralCrossRef
7.
Petros Z. The need of standardized herbal remedies as alternate sources of antimalarial products in Ethiopia—updated review. Pharmacol Online. 2011;3:1440–7.
8.
Ntie-Kang F, Amoa OP, Lifongo LL, Ndom JC, Sippl W, Mbaze LM. The potential of anti-malarial compounds derived from African medicinal plants, part II: a pharmacological evaluation of non-alkaloids and non-terpenoids. Malar J. 2014;13:81.PubMedPubMedCentralCrossRef
9.
Phillipson D, Wright W. Can ethnopharmacology contribute to the development of anti- malarial agents? J Ethnopharmacol. 1991;32:155–65.PubMedCrossRef
10.
Fullas F. The role of indigenous medicinal plants in Ethiopian healthcare. London: African Renaissance; 2007.
11.
12.
Pankhurst R. A historical reflection on the traditional Ethiopian pharmacopeias. J Ethiop Pharm Assoc. 1965;2:29–33.
13.
Debella A, Taye A, Abebe D, Mudi K, Melaku D, Taye G. Screening of some Ethiopian medicinal plants for mosquito larvicidal effects and phytochemical constituents. Pharmacol Online. 2007;33:231–43.
14.
Misganaw N, Moges S, Tadele M, Tesera M, Temesgen T, Raja N. Evaluation of multi potential bioactive endod, Phytolacca dodecandra (L’Herit) berries extracts against immature filarial vector Culex quinquefasciatus Say (Diptera: Culicidae). Res J Environ Earth Sci. 2012;4:697–703.
15.
Mengiste B, Makonnen E, Urga K. In-vivo antimalarial activity of Dodonaea Angustifolia seed extracts against Plasmodium berghei in mice model. Momona Ethiop J Sci. 2012;4:47–63.
16.
Eyasu M, Shibeshi W, Giday M. In vivo antimalarial activity of hydromethanolic leaf extract of Calpurnia aurea (Fabaceae) in mice infected with chloroquine sensitive Plasmodium berghei. Int J Pharmacol. 2013;2:131–42.
17.
Bantie L, Assefa S, Teklehaimanot T, Engidawork E. In vivo antimalarial activity of the 51 crude leaf extract and solvent fractions of Croton macrostachyus Hocsht (Euphorbiaceae) against Plasmodium berghei in mice. BMC Complement Alternat Med. 2014;14:79.CrossRef
18.
Hunde D, Asfaw Z, Kelbessa E. Use of traditional medicinal plants by people of ‘Boosat’ sub district, Central Eastern Ethiopia. Ethiop J Health Sci. 2006;16:141–55.
19.
Willcox M, Benoit-Vical F, Fowler D, Bourdy G, Burford G, Giani S, et al. Do ethnobotanical and laboratory data predict clinical safety and efficacy of anti-malarial plants? Malar J. 2011;10(Suppl 1):S7.PubMedPubMedCentralCrossRef
20.
Ketema T, Bacha K, Birhanu T, Petros B. Chloroquine-resistant Plasmodium vivax malaria in Serbo town, Jimma zone, south-west Ethiopia. Malar J. 2009;8:177.PubMedPubMedCentralCrossRef
21.
Asnake S, Teklehaymanot T, Hymete A, Erko B, Giday M. Survey of medicinal plants used to treat malaria by Sidama People of Boricha District, Sidama Zone, South Region of Ethiopia. Evid Based Complement Alternat Med. 2016; ID 9690164.
22.
23.
Dori UG, Deressa W, Esposito F, Habluetzel A. Perceptions and practices of the Konso community (South-west Ethiopia) relating to malaria: implications for control. Malar World J. 2012;3:9.
24.
Maryo M, Nemomissa S, Bekele T. An ethnobotanical study of medicinal plants of the Kembatta ethnic group in Enset-based agricultural landscape of Kembatta Tembaro (KT) Zone, Southern Ethiopia. Asian J Plant Sci Res. 2015;5:42–61.
25.
Agisho H, Osie M, Lambore T. Traditional medicinal plants utilization, management and threats in Hadiya Zone, Ethiopia. J Med Plants Stud. 2014;2:94–108.
26.
27.
28.
Mesfn F, Seta T, Assefa A. An ethnobotanical study of medicinal plants in Amaro Woreda, Ethiopia. Ethnobot Res Appl. 2014;12:341–54.CrossRef
29.
Regassa R. Assessment of indigenous knowledge of medicinal plant practice and mode of service delivery in Hawassa city, southern Ethiopia. J Med Plants Res. 2013;7:517–35.
30.
Temam T, Dillo A. Ethnobotanical study of medicinal plants of Mirab-Badwacho district, Ethiopia. J BioSci Biotechnol. 2016;5:151–8.
31.
32.
Andarge E, Shonga A, Agize M, Tora A. Utilization and conservation of medicinal plants and their associated indigenous knowledge (IK) in Dawuro Zone: An ethnobotanical approach. Int J Medicinal Plant Res. 2015;4:330–7.
33.
Teklehaymanot T, Giday M. Quantitative ethnobotany of medicinal plants used by Kara and Kwego semi-pastoralist people in lower Omo River Valley, Debub Omo Zone, Southern Nations, Nationalities and Peoples Regional State, Ethiopia. J Ethnopharmacol. 2010;130:76–84.PubMedCrossRef
34.
Assefa A, Abebe T. Ethnobotanical study of wild medicinal trees and shrubs in Benna Tsemay District, Southern Ethiopia. J Sci Dev. 2014;2:1.
35.
Seid MA, Aydagnehum SG. Medicinal plants biodiversity and local healthcare management system in Chencha District, Gamo Gofa, Ethiopia. J Pharmacogn Phytochem. 2013;2:284–93.
36.
Giday M, Asfaw Z, Woldu Z. Ethnomedicinal study of plants used by Sheko ethnic group of Ethiopia. J Ethnopharmacol. 2010;132:75–85.PubMedCrossRef
37.
Giday M, Asfaw Z, Woldu Z, Teklehaymanot T. Medicinal plant knowledge of the Bench ethnic group of Ethiopia: an ethnobotanical investigation. J Ethnobiol Ethnomed. 2009;5:24–34.CrossRef
38.
Giday M, Asfaw Z, Woldu Z. Medicinal plants of the Meinit ethnic group of Ethiopia: an ethnobotanical study. J Ethnopharm. 2009;124:513–21.CrossRef
39.
Tolossa K, Debela E, Athanasiadou S, Tolera A, Ganga G, Jos G. Ethno-medicinal study of plants used for treatment of human and livestock ailments by traditional healers in South Omo, Southern Ethiopia. J Ethnobiol Ethnomed. 2013;9:32.PubMedPubMedCentralCrossRef
40.
Abbink J. Plant use among the Suri people of southern Ethiopia: a system of knowledge in danger? Afrikanistische Arbeitspapiere. 2002;70:199–206.
41.
Zerabruk S, Yirga G. Traditional knowledge of medicinal plants in Gindeberet district, Western Ethiopia. S Afr J Bot. 2012;78:165–9.CrossRef
42.
Eneyew A, Asfaw Z, Kelbessa E, Nagappan R. Ethnobotanical study of traditional medicinal plants in and around Fiche District, Central Ethiopia. Curr Res J Biol Sci. 2014;6:154–67.
43.
Megersa M, Asfaw Z, Kelbessa E, Beyene A, Woldeab B. An ethnobotanical study of medicinal plants in Wayu Tuka District, East Welega Zone of Oromia Regional State, West Ethiopia. J Ethnobiol Ethnomed. 2013;9:68.PubMedPubMedCentralCrossRef
44.
Tadesse M, Hunde D, Getachew Y. Survey of medicinal plants used to treat human diseases in Seka Cherkosa, Jimma Zone, Ethiopia. Ethiop J Health. 2005;15:89–106.
45.
46.
Birhanu T, Abera D, Ejeta E. Ethnobotanical study of medicinal plants in selected Horro Gudurru Woredas, Western Ethiopia. J Biol Agric Healthc. 2015;5:83–93.
47.
Kenea O, Tekie H. Ethnobotanical survey of plants traditionally used for malaria prevention and treatment in selected resettlement and indigenous villages in Sasiga District, Western Ethiopia. J Biol Agric Healthc. 2015;5:1–9.
48.
49.
50.
51.
Belayneh A, Asfaw Z, Demissew S, Bussa NF. Medicinal plants potential and use by pastoral and agro-pastoral communities in Erer Valley of Babile Wereda, Eastern Ethiopia. J Ethnobiol Ethnomed. 2012;8:42.PubMedPubMedCentralCrossRef
52.
Lulekal E, Kelbessa E, Bekele T, Yineger H. An ethnobotanical study of medicinal plants in Mana Angetu District, southeastern Ethiopia. J Ethnobiol Ethnomed. 2008;4:10.PubMedPubMedCentralCrossRef
53.
Beche D, Gebeyehu G, Feyisa K. Indigenous utilization and management of useful plants in and around Awash National Park, Ethiopia. J Plant Biol Soil Health. 2016;3:12.
54.
Hunde D, Asfaw Z, Kelbessa E. Use of traditional medicinal plants by people of ‘Boosat’ Sub District, Central Eastern Ethiopia. Ethiop J Health Sci. 2006;16:141–55.
55.
Eshete AM, Kelbessa E, Dalle G. Ethnobotanical study of medicinal plants in Guji Agro-pastoralists, Blue Hora District of Borana Zone, Oromia Region, Ethiopia. J Med Plants Stud. 2016;4:170–84.
56.
Bekele G, Reddy PR. Ethnobotanical study of medicinal plants used to treat human ailments by Guji Oromo Tribes in Abaya District, Borana, Oromia, Ethiopia. Univers J Plant Sci. 2015;3:1–8.CrossRef
57.
58.
Parvez N, Yadav S. Ethnopharmacology of single herbal preparations of medicinal plants in Asendabo district, Jimma, Ethiopia. Indian J Tradit Knowl. 2010;9:724–9.
59.
Asefa A, Urga K, Guta M, Mekonene W, Melaku D, Mudie K, et al. In vivo antimalarial activities of plants used in Ethiopian traditional medicine, Delomenna, Southeast Ethiopia. Ethiop J Health Sci. 2007;17:1–12.
60.
Balemie K, Kelbessa E, Asfaw Z. Indigenous medicinal plant utilization, management and threats in Fentalle Area, Eastern Shewa, Ethiopia. Ethiop J Biol Sci. 2004;3:37–58.
61.
Eneyew A, Asfaw Z, Kelbessa E, Nagappan R. Status of medico-cultural commercial plants at fiche town market Ethiopia. Int J Pharm Healthcare Res. 2013;1:227–36.
62.
Abera B. Medicinal plants used in traditional medicine in Jimma Zone, Oromia, Southwest Ethiopia. Ethiop J Health Sci. 2003;13:85–94.
63.
Feyssa DH, Njoka JT, Asfaw Z, Nyangito MM. Uses and management of Ximenia americana, Olacaceae in semi-arid East Shewa, Ethiopia. Pakistan J Bot. 2012;44:1177–84.
64.
Wondimu T, Asfaw Z, Kelbessa E. Ethnobotanical study of medicinal plants around ‘Dheeraa’ town, Arsi Zone, Ethiopia. J Ethnopharmacol. 2007;112:152–61.PubMedCrossRef
65.
66.
Berhan A, Asfaw Z, Kelbessa E. Ethnobotany of plants used as insecticides, repellents and anti-malarial agents in Jabitehnan District, West Gojjam. SINET Ethiop J Sci. 2006;29:87–92.CrossRef
67.
Limenih Y, Umer S, Wolde-Mariam M. Ethnobotanical study on traditional medicinal plants in Dega Damot Woreda, Amhara Region, North Ethiopia. Int J Res Pharm Chem. 2015;5:258–73.
68.
69.
Giday M, Teklehaymanot T, Animut A, Mekonnen Y. Medicinal plants of the Shinasha, Agew-awi and Amharapeoples in northwest Ethiopia. J Ethnopharmacol. 2007;110:516–25.PubMedCrossRef
70.
Getaneh S, Girma Z. An ethnobotanical study of medicinal plants in Debre Libanos Wereda, Central Ethiopia. Afr J Plant Sci. 2014;8:366–79.CrossRef
71.
72.
Getnet Z, Chandrodyam S, Masresha G. Studies on traditional medicinal plants in Ambagiorgis area of Wogera District, Amhara Regional State, Ethiopia. Int J Pure Appl Biosci. 2016;4:38–45.CrossRef
73.
Teklehaymanot T, Giday M, Medihin G, Mekonnen Y. Knowledge and use of medicinal plants by people around Debrelibanos Monastery in Ethiopia. J Ethnopharmacol Ethnomed. 2007;111:271–83.CrossRef
74.
Alemayehu G, Asfaw Z, Kelbessa E. Ethnobotanical study on medicinal plants used by indigenous local communities in Minjar-Shenkora Wereda, North Shewa Zone of Amhara Region, Ethiopia. J Med Plants Stud. 2015;3:1–11.
75.
Chekole G, Asfaw Z, Kelbessa E. An ethnobotanical study of plants used in traditional medicine and as wild foods in and around Tara Gedam and Amba remnant forests in Libo Kemkem Wereda, South Gonder zone, Amhara region, Ethiopia. J Ethnobiol Ethnomed. 2015;11:4.PubMedPubMedCentralCrossRef
76.
Lulekal E, Asfaw Z, Kelbessa E, Van Damme P. Ethnomedicinal study of plants used for human ailmentsin Ankober district, North Shewa zone, Amhara region,Ethiopia. J Ethnobiol Ethnomed. 2013;9:63.PubMedPubMedCentralCrossRef
77.
Mohammed A. Traditional use, management and conservation of useful plants in dry land parts of north Shoa zone of the Amhara national region: an ethnobotanical approach. MSc Thesis. Addis Ababa: Addis Ababa University; 2004.
78.
Alemayehu G, Asfaw Z, Kelbessa E. Plant diversity and ethnobotany in Berehet District, North Shewa Zone of Amhara Region (Ethiopia) with emphasis on wild edible plants. J Med Plants Stud. 2015;3:93–105.
79.
Mekuanent T, Zebene A, Solomon Z. Ethnobotanical study of medicinal plants in Chilga district, Northwestern Ethiopia. J Nat Remedies. 2015;15:2320–3358.
80.
Ragunathan M, Abay SM. Ethnomedicinal survey of folk drugs used in Bahirdar Zuria district,Northwestern Ethiopia. Indian J Trad Knowl. 2009;8:281–4.
81.
82.
Teklehaymanot T, Giday M. Ethnobotanical study of medicinal plants used by people in Zegie peninsula, Northwestern Ethiopia. J Ethnobiol Ethnomed. 2007;3:12.PubMedPubMedCentralCrossRef
83.
Meragiaw M, Asfaw Z, ArgawM. The Status of Ethnobotanical Knowledge of Medicinal Plants and the Impacts of Resettlement in Delanta, Northwestern Wello, Northern Ethiopia. Evid Based Complement Alternat Med. 2016; ID 5060247.
84.
Birhanu Z, Endale A, Shewamene Z. An ethnomedicinal investigation of plants used by traditional healers of Gondar town, NorthWestern Ethiopia. J Med Plants Stud. 2015;3:36–43.
85.
86.
Mesfin A, Giday M, Animut A, Teklehaymanot T. Ethnobotanical study of antimalarial plants in Shinile District, Somali Region, Ethiopia, and in vivo evaluation of selected onesagainst P. berghei. J Ethnopharmacol. 2012;139:221–7.PubMedCrossRef
87.
Araya S, Abera B, Giday M. Study of plants traditionally used in public and animal health management in Seharti Samre District, Southern Tigray, Ethiopia. J Ethnobiol Ethnomed. 2015;11:22.PubMedPubMedCentralCrossRef
88.
Teklay A, Abera B, Giday M. An ethnobotanical study of medicinal plants used in Kilte Awulaelo district, Tigray Region of Ethiopia. J Ethnobiol Ethnomed. 2013;9:65.PubMedPubMedCentralCrossRef
89.
Mesfin K, Tekle G, Tesfay T. Ethnobotanical study of traditional medicinal plants used by indigenous people of Gemad District, Northern Ethiopia. J Med Plants Stud. 2013;1:4.
90.
Yirga G. Assessment of traditional medicinal plants in Endrta District, South-eastern Tigray, Northern Ethiopia. Afr J Plant Sci. 2010;4:255–60.
91.
Birhane E, Aynekulu E, Mekuria W, Endale D. Management, use and ecology of medicinal plants in the degraded dry lands of Tigray, northern Ethiopia. J Med Plants Res. 2011;5:309–18.
92.
Gidey M, Beyene T, Signorini MA, Bruschi P, Yirga G. Traditional medicinal plants used by Kunama ethnic group in Northern Ethiopia. J Med Plants Res. 2015;9:494–509.CrossRef
93.
Zenebe G, Zerihun M, Solomon Z. An ethnobotanical study of medicinal plants in Asgede Tsimbila District, Northwestern Tigray, Northern Ethiopia. Ethnobot Res Appl. 2012;10:305–20.CrossRef
94.
95.
Yirga G. Assessment of indigenous knowledge of medicinal plants in Central Zone of Tigray, Northern Ethiopia. Afr J Plant Sci. 2010;4:6–11.
96.
Edwards S. The ecology and conservation status of medicinal plants on Ethiopia - What do we know? In: Medhin Z, Abebe D, editors. Conservation and Sustainable use of medicinal plants in Ethiopia, Proceedings of National Workshop on Biodiversity Conservation and Sustainable use of medicinal plants in Ethiopia. Addis Ababa: Institute of Biodiversity Conservation and Research; 2001. p. 46–55.
97.
Yineger H, Yewhalaw D. Traditional medicinal plant knowledge and use by local healers in Sekoru District, Jimma Zone, Southwestern Ethiopia. J Ethnobiol Ethnomed. 2007;3:24.PubMedPubMedCentralCrossRef
98.
Bekele B, Asfaw Z, Petros B, Tekie H. Ethnobotanical study of plants used for protection against insect bite and for the treatment of livestock health problems in rural areas of Akaki District, Eastern Shewa, Ethiopia. Topclass J Herbal Med. 2012;1:12–24.
99.
Berhane T, Vijaibasker G. Assessment of traditional home remedy usage among people in Harar, Ethiopia. Int J Pharm Sci Res. 2015;6:2451–61.
100.
Seifu T, Asres K, Gebre-Mariam T. Ethnobotanical and ethnopharmaceutical studies on medicinal plants of Chifra District, Afar Region, North Eastern Ethiopia. Ethiop Pharm J. 2006;24:41–58.
101.
Meragiaw M. Wild useful plants with emphasis on traditional use of medicinal and edible plants by the people of Aba’ala, North-eastern Ethiopia. J Med Plant Herb Ther Res. 2016;4:1–16.
102.
Belayneh A, Bussa NF. Ethnomedicinal plants used to treat human ailments in the prehistoric place of Harla andDengego valleys, eastern Ethiopia. J Ethnobiol Ethnomed. 2014;10:18.PubMedPubMedCentralCrossRef
103.
Mengesha GG. Ethnobotanical survey of medicinal plants used in treating human and livestock health problems in Mandura Woreda of Benishangul Gumuz, Ethiopia. Adv Med Plant Res. 2016;4:11–26.
104.
Flatie T, Gedif T, Asres K, Gebre-Mariam T. Ethnomedical survey of Berta ethnic group Assosa Zone, BenishangulGumuz regional state, mid-west Ethiopia. J Ethnobiol Ethnomed. 2009;5:14.PubMedPubMedCentralCrossRef
105.
Nguta JM, Mbaria JM, Gakuya DW, Gathumbi PK, Kiama SG. Antimalarial herbal remedies of Msambweni, Kenya. J Ethnopharmacol. 2010;128:424–32.PubMedCrossRef
106.
Tabuti JRS, Lye KA, Dhillion SS. Traditional herbal drugs of Bulamogi, Uganda: plants, use and administration. J Ethnopharmacol. 2003;88:19–44.PubMedCrossRef
107.
Asase A, Akwetey GA, Achel DG. Ethnopharmacological use of herbal remedies for the treatment of malaria in the Dangme West District of Ghana. J Ethnopharmacol. 2010;3:367–76.CrossRef
108.
Muthaura CN, Rukunga GM, Chhabra SC, Mungai GM, Njagi ENM. Traditional phytotherapy of some remedies used in treatment of malaria in Meru district of Kenya. S Afr J Bot. 2007;73:402–11.CrossRef
109.
Mpiana PT, Ngbolua KN, Mudogo V, Tshibangu DST, Atibu EK, Mbala BM, et al. The potential effectiveness of medicinal plants used for the treatment of sickle cell disease in the Democratic Republic of Congo folk medicine: a review. In: Gupta VK, Singh GD, editors. Traditional and folk herbal medicine. New Delhi: Daya Publishing House; 2012.
110.
Sofowora A. Medicinal plants and traditional medicine in Africa. 2nd ed. Spectrum Books; 1993. ISBN 9782462195, 9789782462190.
111.
Dibong SD, Mbondo ME, Ngoye A, Kwin MF, Betti JC. Ethnobotanique et phytomédecine des plantes médicinales de Douala, Cameroun. J Appl Biosci. 2011;37:2496–507.
112.
Adekunle MF. Indigenous uses of plant leaves to treat malaria fever at Omo Forest reserve (OFR) Ogun state, Nigeria. Ethiop J Environ Stud Manag. 2008;1:31–5.
113.
Musa SM, Abdelrasool FE, Elsheikh AE, Ahmed LAMN, Mahmoud ALE, Yagil SM. Ethnobotanical study of medicinal plants in the Blue Nile State, South-eastern Sudan. J Med Plants Res. 2011;5:4287–97.
114.
115.
Katemo M, Mpiana PT, Mbala BM, Mihigo SO, Ngbolua KN, Tshibangu DST, et al. Ethnopharmacological survey of plants used against diabetes in Kisangani City (D.R. Congo). J Ethnopharmacol. 2012;144:39–43.PubMedCrossRef
116.
Idowu OA, Soniran OT, Ajana O, Aworinde DO. Ethnobotanical survey of antimalarial plants used in Ogun State, Southwest Nigeria. Afr J Pharm Pharmacol. 2010;4:55–60.
117.
Pousset JL. Plantes médicinales africaines. Utilisation pratique, vol. 2. Paris: ACCT; 1989.
118.
Addis G, Baskaran R, Raju M, Ushadevi A, Asfaw Z, Woldu Z, Baskaran V. Effect of blanching and drying process on carotenoids composition of underutilized Ethiopian (Coccinia grandis L. Voigt) and Indian (Trigonella foenum-graecum L.) green leafy vegetables. J Food Process Preserv. 2009;33:744–62.CrossRef
119.
Getahun A. Some common medicinal and poisonous plants used in Ethiopian folk medicine. Addis Abeba: Addis Abeba University; 1976. p. 3–63.
120.
Sofowora EA. Medicinal plants and traditional medicine in Africa. New York: Wiley; 1982.
121.
Abebe D. Traditional medicine in Ethiopia: the attempts being made to promote it for effective and better utilization. SINET Ethiop J Sci. 1986;96:1–69.
122.
Giday M, Asfaw Z, Elmquist T, Woldu Z. An ethnobotanical study of medicinal plants used by Zay people in Ethiopia. J Ethnopharmacol. 2003;85:43–52.PubMedCrossRef
123.
Mueller MS, Runyambo N, Wagner I, Borrmann S, Dietz K, Heide L. Randomized controlled trial of a traditional preparation of Artemisia annua L (Annual Wormwood) in the treatment of malaria. Trans R Soc Trop Med Hyg. 2004;98:318–21.PubMedCrossRef
124.
Yao-De W, Qi-Zhong Z, Jie-Sheng W. Studies on the antimalarial action of gelatin capsule of Artemisia annua. Clin J Parasitol. 1992;10:290–4.
125.
Kuria KAM, Chepkwony H, Govaerts C, Roets E, Busson R, de Witte P, et al. The antiplasmodial activity of isolates from Ajuga remota. J Nat Prod. 2002;65:789–93.PubMedCrossRef
126.
Bidla G, Titanji VPK, Jako B, Ghazali GE, Bolad A, Berzins K. Anti-plasmodial activity of seven plants used in African folk medicine. Indian J Pharm. 2004;36:245–6.
127.
Kirira PG, Rukunga GM, Wanyonyi AW, Muregi FM, Gathirwa JW, Muthaura CN, et al. Anti-plasmodial activity and toxicity of extracts of plants used in traditional malaria therapy in Meruand Kilifi Districts of Kenya. J Ethnopharm. 2006;106:403–7.CrossRef
128.
MacKinnon S, Durst T, Arnason JT, Angerhofer C, Pezutto J, Sanchez-Vindas PE, et al. Antimalarial activity of tropical Meliaceae extracts and gedunin derivatives. J Nat Prod. 1997;60:336–41.PubMedCrossRef
129.
Simoes-Pires CA. Investigation of antiplasmodial compounds from various plant extracts: Argemone mexicana L. (Papaveraceae), Licania octandra (Hoffmanns. ex. Roem & Schult) Kuntze (Chrysobalanaceae) and Syzygium cumini (L.) Skeels (Myrtaceae). Geneva: Université de Geneve, Section des Sciences Pharmaceutiques, Laboratoire de Pharmacognosie et Phytochimie; 2009.
130.
Willcox ML, Graz B, Falquet J, Sidibe O, Forster M, Diallo D. Argemone Mexicana decoction for the treatment of uncomplicated falciparum malaria. Trans R Soc Trop Med Hyg. 2007;101:1190–8.PubMedCrossRef
131.
Ohigashi H, Hoffman MA, Izutsu D, Koshimizu K, Kawanaka M, Sugiyama H, et al. Toward the chemical ecology of medicinal plant use in chimpanzees: the case of Vernonia amygdalina, a plant used by wild chimpanzees possibly for parasite-related diseases. J Chem Ecol. 1994;20:541–53.PubMedCrossRef
132.
Cubukcu B, Bray DH, Warhurst DC, Mericli AH, Ozhatay N, Sariyar G. In vitro antimalarial activity of crude extracts and compounds from Artemisia abrotanum L. Phytother Res. 1990;4:203–4.CrossRef
133.
Pillay P, Vleggaar R, Maharaj VJ, Smith PJ, Lategan CA, Chouteau F, et al. Antiplasmodial hirsutinolides from Vernonia staehelinoides and their utilization towards a simplified pharmacophore. Phytochem. 2007;68:1200–5.CrossRef
134.
Tona L, Cimanga RK, Mesia K, Musuamba CT, De Bruyne T, Apers S, et al. In vitro antiplasmodial activity of extracts and fractions from seven medicinal plants used in the Democratic Republic of Congo. J Ethnopharmacol. 2004;93:27–32.PubMedCrossRef
135.
Challand S, Willcox M. A clinical trial of the traditional medicine Vernonia amygdalina in the treatment of uncomplicated malaria. J Altern Complement Med. 2009;15:1231–7.PubMedCrossRef
136.
Oketch-Rabah HA, Dossaji SF, Christensen SB, Frydenvang K, Lemmich E. Antiprotozoal compounds from Asparagus africanus. J Nat Prod. 1997;60:1017–22.PubMedCrossRef
137.
Nkunya MH, Weenen H, Bray DH, Mgani QA, Mwasumbi LB. Antimalarial activity of Tanzanian plants and their active constituents: the genus Uvaria1. Planta Med. 1991;57:341–3.PubMedCrossRef
138.
Deck LM, Royer RE, Chamblee BB, Hernandez VM, Malone RR, Torres JE, et al. Selective inhibitors of human lactate dehydrogenases and lactate dehydrogenase from the malarial parasite Plasmodium falciparum. J Med Chem. 1998;41:3879–87.PubMedCrossRef
139.
Musuyu Muganza D, Fruth BI, Nzunzu Lami J, Mesia GK, Kambu OK, Tona GL, et al. In vitro antiprotozoal and cytotoxic activity of 33 ethonopharmacologically selected medicinal plants from Democratic Republic of Congo. J Ethnopharmacol. 2012;141:301–8.PubMedCrossRef
140.
Koch A, Tamez P, Pezzuto J, Soejarto D. Evaluation of plants used for antimalarial treatment by the Masai of Kenya. J Ethnopharm. 2005;101:95–9.CrossRef
141.
Gakunju DMN, Mberu EK, Dossaji SF, Gray AI, Waigh RD, Waterman PG, et al. Potent antimalarial activity of the alkaloid nitidine, isolated from a Kenyan herbal remedy. Antimicrob Agents Chemother. 1995;39:2606–9.PubMedPubMedCentralCrossRef
142.
Bah S, Jager AK, Adsersen A, Diallo D, Paulsen BS. Antiplasmodial and GABA(A)- benzodiazepine receptor binding activities of five plants used in traditional medicine in Mali, West Africa. J Ethnopharmacol. 2007;110:451–7.PubMedCrossRef
143.
Okpako LC, Ajaiyeoba EO. In vitro and in vivo antimalarial studies of Striga hermothica and Tapinanthus sessilifolius extracts. Afr J Med Sci. 2004;33:73–5.
144.
Vonthron-Senecheau C, Weniger B, Ouattara M, Bi FT, Kamenan A, Lobstein A, et al. In vitro antiplasmodial activity and cytotoxicity of ethnobotanically selected Ivorian plants. J Ethnopharmacol. 2003;87:221–5.PubMedCrossRef
145.
Julianti T, De Mieri M, Zimmermann S, Ebrahimi SN, Kaiser M, Neuburger M, et al. HPLC based activity profiling for antiplasmodial compounds in the traditional Indonesian medicinal plant Carica papaya L. J Ethnopharmacol. 2014;155:426–34.PubMedCrossRef
146.
Dold AL, Cocks ML. The trade in medicinal plants in the Eastern Cape Province, South Africa. S Afr J Sci. 2002;98:589.
147.
Abdel-Azim NS, Shams KA, Shahat AA, EL-Missiry MM, Ismail SI, Hammouda FM. Egyptian herbal drug industry: challenges and future prospects. Res J Med Plants. 2011;5:136–44.CrossRef
Metadata
Title
Systematic review on traditional medicinal plants used for the treatment of malaria in Ethiopia: trends and perspectives
Authors
Getachew Alebie
Befikadu Urga
Amha Worku
Publication date
01-12-2017
Publisher
BioMed Central
Published in
Malaria Journal / Issue 1/2017
Electronic ISSN: 1475-2875
DOI
https://doi.org/10.1186/s12936-017-1953-2

Other articles of this Issue 1/2017

Malaria Journal 1/2017 Go to the issue

Research

An epidemiological study to assess Plasmodium falciparum parasite prevalence and malaria control measures in Burkina Faso and Senegal

Research

Molecular characterization of Anopheline (Diptera: Culicidae) mosquitoes from eight geographical locations of Sri Lanka

Research

Measuring ex vivo drug susceptibility in Plasmodium vivax isolates from Cambodia

Research

Community perceptions and attitudes on malaria case management and the role of community health workers

Research

Modelling the impact of the long-term use of insecticide-treated bed nets on Anopheles mosquito biting time

Case Study

Effectiveness and equity of the Tanzania National Voucher Scheme for mosquito nets over 10 years of implementation

ACC 2024 Congress Coverage

Cardiology Video

Highlights from the ACC 2024 Congress

Watch now

Watch official videos from the ACC congress summarizing key highlights from the last year in heart failure, cardiomyopathies, valvular disease, pulmonary vascular disease, and pediatric cardiology.

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

Image Credits