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Malaria Journal
Published in: Malaria Journal 1/2014

Open Access 01-12-2014 | Review

The potential of anti-malarial compounds derived from African medicinal plants, part II: a pharmacological evaluation of non-alkaloids and non-terpenoids

Authors: Fidele Ntie-Kang, Pascal Amoa Onguéné, Lydia L Lifongo, Jean Claude Ndom, Wolfgang Sippl, Luc Meva’a Mbaze

Published in: Malaria Journal | Issue 1/2014

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Abstract

Malaria is currently a public health concern in many countries in the world due to various factors which are not yet under check. Drug discovery projects targeting malaria often resort to natural sources in the search for lead compounds. A survey of the literature has led to a summary of the major findings regarding plant-derived compounds from African flora, which have shown anti-malarial/antiplasmodial activities, tested by in vitro and in vivo assays. Considerations have been given to compounds with activities ranging from “very active” to “weakly active”, leading to >500 chemical structures, mainly alkaloids, terpenoids, flavonoids, coumarins, phenolics, polyacetylenes, xanthones, quinones, steroids and lignans. However, only the compounds that showed anti-malarial activity, from “very active” to “moderately active”, are discussed in this review.
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Metadata
Title
The potential of anti-malarial compounds derived from African medicinal plants, part II: a pharmacological evaluation of non-alkaloids and non-terpenoids
Authors
Fidele Ntie-Kang
Pascal Amoa Onguéné
Lydia L Lifongo
Jean Claude Ndom
Wolfgang Sippl
Luc Meva’a Mbaze
Publication date
01-12-2014
Publisher
BioMed Central
Published in
Malaria Journal / Issue 1/2014
Electronic ISSN: 1475-2875
DOI
https://doi.org/10.1186/1475-2875-13-81

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