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BMC Musculoskeletal Disorders

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Open Access 01-12-2019 | Ovariectomy | Research article

Bone mesenchymal stem cell therapy for ovariectomized osteoporotic rats: a systematic review and meta-analysis

Authors: Zhenxiong Jin, Jinman Chen, Bing Shu, Yanhua Xiao, Dezhi Tang

Published in: BMC Musculoskeletal Disorders | Issue 1/2019

Abstract

Background

Previous studies have found that bone mesenchymal stem cells (BMSCs) were capable of self-replication, multi-differentiation, and regeneration. The aim of this study was to carry out a systematic review and meta-analysis of the efficacy of BMSC therapy for ovariectomized rats.

Methods

The PubMed, Embase, Web of Science, China National Knowledge Infrastructure, VIP, and Chinese Sinomed databases were searched systematically from their initiation date to October 5, 2018. Two researchers independently screened the literatures, which used the bone mineral density (BMD), total bone volume by total tissue volume (BV/TV) (%), and trabecular thickness/spacing (Tb/Sp) as the outcome measures.

Results

Five eligible studies were selected. In the BMSC treatment groups, the BMD values and normalized BV/TV values remarkably increased. In addition, in the BMSCs plus other treatment groups, the BMD and Tb/Sp values significantly increased.

Conclusion

This study showed that BMSCs could accelerate callus maturity, ossification and restore mechanical properties of bones in osteoporotic fractures.

Rajasekaran S, Kanna RM, Schnake KJ. Vaccaro. A R, Schroeder. G D, sadiqi. S, Oner. C. Osteoporotic thoracolumbar fractures-how are they different-classification and treatment algorithm. J Orthop Trauma. 2017;31(4):S49–56.PubMedCrossRef

Cosman F, de Beur SJ, LeBoff MS. Lewiecki. E M, Tanner. B, Randall. S, Lindsay. R, Clinician's guide to prevention and treatment of osteoporosis. Osteoporos Int. 2014;25(10):2359–81.PubMedPubMedCentralCrossRef

Zhang ZH, Liu ZH, Shi SH. A retrospective study of the incidence of osteoporosis diagnosed with −2.5SD in mainland China. Chi J Osteoporos. 2015;22(1):1–7.

Elsafadi M, Manikandan M, Atteya M, Hashmi JA, Iqbal Z, Aldahmash A, Alfayez M, Kassem M, Mahmood A. Characterization of cellular and molecular heterogeneity of bone marrow stromal cells. Stem Cells Int. 2016;2016:9378081.CrossRef

Kuznetsov SA, Riminucci M, Ziran N, Tsutsui TW, Corsi A, Calvi L, Kronenberg HM, Schipani E, Robey PG, Bianco P. The interplay of osteogenesis and hematopoiesis: expression of a constitutively active PTH/PTHrP receptor in osteogenic cells perturbs the establishment of hematopoiesis in bone and of skeletal stem cells in the bone marrow. J Cell Biol. 2004;167(6):1113–22.PubMedPubMedCentralCrossRef

Hu CF. Analysis of clinical efficacy of autologous bone marrow stem cell transplantation therapy in 106 patients with severe lower limb ischemia. J Hainan Med Coll. 2013;19(3):365–6 370.

ZHANG XY, ZHAO G, SHANG W. Perioperative drug therapy for osteoporotic fractures. Chin J Osteoporos. 2014;20(02):214–8.

Bianco P, Cao X, Frenette PS, Mao JJ, Robey PG, Simmons PJ, Wang CY. The meaning, the sense and the significance: translating the science of mesenchymal stem cells into medicine. Nat Med. 2013;19(1):35–42.PubMedPubMedCentralCrossRef

Lozano-Rivas N, Linares LF, Marras-Fernandez-Cid C, GarciaHernandez AM, Algueró MDC, Iniesta F, Sanchez-Salinas D, LópezLucas MD, Rodriguez-Valiente M, Cabañas V, García-Bernal D, Molina MDM, Lopez S, Ramirez-Tovar F, Sará JER, García B, Blanquer M, Fernandez-Delgado JAO, Espinosa M, Zamarro J, Becerra-Ratia J, Peris JL, López-Exposito I, Bafalliu JA, Ruiz-Espejo F. Clinical trial of intravenous infusion offucosylated bone marrow mesenchymal stem cells in patients with osteoporosis. Ann Rheum Dis. 2018. https://doi.org/10.1136/annrheumdis-2018-eular.6625 (Scientific Abstracts).

10.

Mathavan N, Turunen M, Tagil M, et al. Characterising bone material composition and structure in the Ovariectomized (OVX) rat model of osteoporosis. J Calcif Tissue Int. 2015;97(2):134–44.CrossRef

11.

Kalu DN. The ovariectomized rat model of postmenopausal bone loss. Bone Miner. 1991;15(3):175–91 Epub 1991/12/01. PMID: 1773131.PubMedCrossRef

12.

Chen L, Yang L, Yao M, Cui XJ, Xue CC, Wang YJ, Shu B. Biomechanical characteristics of osteoporotic fracture healing in Ovariectomized rats: a systematic review. PLoS One. 2016;11(4):e0153120.PubMedPubMedCentralCrossRef

13.

Johnston BD, Ward WE. The Ovariectomized rat as a model for studying alveolar bone loss in postmenopausal women. J BioMed Res Int. 2015;2015:1–12.CrossRef

14.

Tang D, Ju C, Liu Y, Xu F, Wang Z, Wang D. Therapeutic effect of icariin combined with stem cells on postmenopausal osteoporosis in rats. J Bone Miner Metab. 2018;36(2):180-8.PubMedCrossRef

15.

Yu Z, Zhu T, Li C, Shi X, Liu X, Yang X, Sun H. Improvement of intertrochanteric bone quality in osteoporotic female rats after injection of polylactic acid-polyglycolic acid copolymer/collagen type I microspheres combined with bone mesenchymal stem cells. Int Orthop. 2012;36(10):2163–71.PubMedPubMedCentralCrossRef

16.

XU ZW, Liu G. Effects of BMSCs transplantation on the healing of osteoporotic fracture in model rats. Shandong J Tradit Chin Med. 2013;(9):51–3.

17.

Liu X, Bao C, Xu HHK, Pan J, Hu J, Wang P, Luo E. Osteoprotegerin gene-modified BMSCs with hydroxyapatite scaffold for treating critical-sized mandibular defects in ovariectomized osteoporotic rats. Acta Biomater. 2016;42:378–88.PubMedCrossRef

18.

Li KC, Chang YH, Yeh CL, Hu YC. Healing of osteoporotic bone defects by baculovirus-engineered bone marrow-derived MSCs expressing MicroRNA sponges. Biomaterials. 2016;74:155–66.PubMedCrossRef

19.

Xu R, Fu Z, Liu X, Xiao T, Zhang P, Du Y, Yuan H, Cheng J, Jiang H. Transplantation of osteoporotic bone marrow stromal cells rejuvenated by the overexpression of SATB2 prevents alveolar bone loss in ovariectomized rats. Exp Gerontol. 2016;84:71–9.PubMedCrossRef

20.

Lee RH, Pulin AA, Seo MJ. Intravenous hMSCs improve myocardialinfarction in mice because cells embolized in lung are activated tosecrete the anti-inflammatory protein TSG-6 cell. Stem Cell. 2009;5:54–63.

21.

Ripperda CM, Maldonado PA, Acevedo JF, Keller PW, Akgul Y, Shelton JM, Word RA. Vaginal estrogen: a dual-edged sword in postoperative healing of the vaginal wall. Menopause. 2017;24(7):838.PubMedPubMedCentralCrossRef

22.

Stroke Therapy Academic Industry Roundtable (STAIR). Recommendations for standards regarding preclinical neuroprotective and restorative drug development. Stroke. 1999;30(12):2752–8.CrossRef

23.

Osugi M, Katagiri W, Yoshimi R, et al. Conditioned media from mesenchymal stem cells enhanced bone regeneration in rat Calvarial bone defects [J]. Tissue Eng A. 2012;18(13–14):1479–89.CrossRef

24.

Fahy N, Alini M, Stoddart MJ. Mechanical stimulation of mesenchymal stem cells: implications for cartilage tissue engineering. Orthop Res. 2018;36(1):52–63.

25.

Hu CF. Autologous bone marrow stem cell transplantation therapy clinical analysis of 106 patients with severe lower limb ischemia patients. J Hainan Med Univ. 2013;19(3):365–366,370.

26.

Ko IK, Lee SJ, Atala A, et al. In situ tissue regeneration through host stem cell recruitment [J]. Exp Mol Med. 2013;45(11):e57.PubMedPubMedCentralCrossRef

27.

WSV B. In situ tissue regeneration: Chemoattractants for endogenous stem cell recruitment [J]. Tissue Eng Part B Rev. 2014;20(1):28–39.

28.

Chen FM, Wu LA, Zhang M, et al. Homing of endogenous stem/progenitor cells for in situ tissue regeneration: promises, strategies, and translational perspectives. J Biomaterials. 2011;32(12):3189–209.CrossRef

29.

Anitua E, Sánchez M, Orive G. Potential of endogenous regenerative technology forin situregenerative medicine [J]. Adv Drug Deliv Rev. 2010;62(7):741–52.PubMedCrossRef

30.

Balakumaran A, Mishra PJ, Pawelczyk E, Yoshizawa S, Sworder BJ, Cherman N, Kuznetsov SA, Bianco P, Giri N, Savage SA, Merlino G, Dumitriu B, Dunbar CE, Young NS, Alter BP, Robey PG. Bone marrow skeletal stem/progenitor cell defects in dyskeratosiscongenita and telomere biology disorders. Blood. 2015;125(5):793.PubMedPubMedCentralCrossRef

31.

Vilalta M, Dégano IR, Bagó J, Gould D, Santos M, García-Arranz M, Ayats R, Fuster C, Chernajovsky Y, García-Olmo D, Rubio N, Blanco J. Biodistribution, Long-term Survival, and Safety of Human Adipose Tissue-derived Mesenchymal Stem Cells Transplanted in Nude Mice by High Sensitivity Non-invasive Bioluminescence Imaging. Stem Cells Dev. 2008;17(5):993–1004.PubMedCrossRef

32.

Torsvik A, Røsland GV, Svendsen A, Molven A, Immervoll H, McCormack E, Lønning PE, Primon M, Sobala E, Tonn JC, Goldbrunner R, Schichor C, Mysliwietz J, Lah TT, Motaln H, Knappskog S, Bjerkvig R. Spontaneous malignant transformation of human mesenchymal stem cells reflects cross-contamination : putting the research field on track - letter. Cancer Res. 2010;70(15):6393.PubMedCrossRef

33.

Uejima S, Okada K, Kagami H, Taguchi A, Ueda M. Bone marrow stromal cell therapy improves femoral bone mineral density and mechanical strength in ovariectomized rats. Cytotherapy. 2008;10(5):479–89.PubMedCrossRef

34.

Caplan AI. Adult mesenchymal stem cells for tissue engineering versus regenerative medicine, J. J Cell Physiol. 2007;213(2):341–7.PubMedCrossRef

35.

Huang DG, Gao YH, Wang SL, Ivanovic Z. A new method for efficient amplification of human adipose-derived mesenchymal stem cells in vitro. J Hainan Med Univ. 2017;28(10):1617–20.

36.

Xiang L, Liang C, Zhen-Yong K, Liang-Jun Y, Zhong-Liang D. BMP9-induced osteogenetic differentiation and bone formation of muscle-derived stem cells. J Biomed Biotechnol. 2012;2012(1):111–3.

37.

Hyun KS, Hyun CJ, Ho LY, Lee JH, Kim SS, Kim MY, Lee MG, Kang WY, Lee KS, Ahn YK, Jeong MH, Kim HS. Improvement in left ventricular function with intracoronary mesenchymal stem cell therapy in a patient with Anterior Wall ST-segment elevation myocardial infarction. Cardiovasc Drugs Ther. 2018;32(4):329-38.PubMedPubMedCentralCrossRef

38.

Monteagudo CS, Ramírez PH, González LA, García-Maeso I, de la Cuétara-Bernal K, Castillo-Díaz L, Bringas-Vega ML, Martínez-Aching G, Morales-Chacón LM, Báez-Martín MM, Sánchez-Catasús C, Carballo-Barreda M, Rodríguez-Rojas R, Gómez-Fernández L, Alberti-Amador E, Macías-Abraham C, Balea ED, Rosales LC, Del Valle Pérez L, Ferrer BB, González RM, Bergado JA. Autologous bone marrow stem cell neurotransplantation in stroke patients. An open study. Restor Neurol Neurosci. 2009;27(3):151.

39.

Hou C, Wu X, Jin X. Autologous Bone Marrow Stromal Cells Transplantation for the Treatment of Secondary Arm Lymphedema: A Prospective Controlled Study in Patients with Breast Cancer Related Lymphedema. Jpn J Clin Oncol. 2008;38(10):670–4.PubMedCrossRef

40.

Fürst G, Schulte am Esch J, Poll LW, Hosch SB, Fritz LB, Klein M, Godehardt E, Krieg A, Wecker B, Stoldt V, Stockschläder M, Eisenberger CF, Mödder U, Knoefel WT. Portal vein embolization and autologous CD133+ bone marrow stem cells for liver regeneration: initial experience. Radiology. 2007;243(1):171–9.PubMedCrossRef

41.

Caplan AI. Adult mesenchymal stem cells and women's health. Menopause. 2015;22(2):131–5.PubMedPubMedCentralCrossRef

42.

Compston JE, McClung MR, Leslie WD. Osteoporosis. Lancet J. 2019;393(10169):364–76.CrossRef

43.

Russow G, Jahn D, Appelt J, Märdian S, Tsitsilonis S, Keller J. Anabolic Therapies in Osteoporosis and Bone Regeneration. Int J Mol Sci. 2018;20(1):pii: E83.CrossRef

44.

Wojda SJ, Donahue SW. Parathyroid hormone for bone regeneration. J Orthop Res. 2018;36(10):2586–94.PubMedCrossRef

45.

Ho-Shui-Ling A, Bolander J, Rustom LE, Johnson AW, Luyten FP, Picart C. Bone regeneration strategies: engineered scaffolds, bioactive molecules and stem cells current stage and future perspectives. Biomaterials. 2018;180:143–62.PubMedPubMedCentralCrossRef

46.

Chang JL, Wang WY, Li YM, Hu SP, Yao M, Cui XJ, Zhi WL, Shi Q, Wang YJ, Yang YP. Chinese herbal medicine for osteosarcoma in the mouse: a systematic review and meta-analysis. Chin J Integr Med. 2019;25(5):370-7.PubMedCrossRef

47.

Friedenstein AJ, Piatetzky S, Petrakova KV. Osteogenesis in transplants of bone marrowcells. Embryol Exp Morphol. 1966;16:381–90.

48.

Qaseem A, Forciea MA, McLean RM, Denberg TD. Treatment of low bone density or osteoporosis to prevent fractures in men and women: a clinical practice guideline update from the American College of Physicians. Ann Intern Med. 2017;166(11):818–39.PubMedCrossRef

Title: Bone mesenchymal stem cell therapy for ovariectomized osteoporotic rats: a systematic review and meta-analysis
Authors: Zhenxiong Jin
Jinman Chen
Bing Shu
Yanhua Xiao
Dezhi Tang
Publication date: 01-12-2019
Publisher: BioMed Central
Keywords: Ovariectomy
Osteoporosis
Osteoporosis
Published in: BMC Musculoskeletal Disorders / Issue 1/2019
Electronic ISSN: 1471-2474
DOI: https://doi.org/10.1186/s12891-019-2851-2

At a glance: The STEP trials

Springer Medicine

Bone mesenchymal stem cell therapy for ovariectomized osteoporotic rats: a systematic review and meta-analysis

Abstract

Background

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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