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Ovariectomy 

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  1. 18-03-2024 | Ovariectomy | Online First

    Impact of ovariectomy on neurotransmitter receptors BDNF/TrkB and endoplasmic reticulum molecular chaperones in rat hypoglossal nucleus

    Currently hypoglossal nerve–genioglossus axis is the major research core of OSA pathogenesis. The pathogenesis of OSA incidence changes before and after menopause needs to be clarified further. Little is known about the influences of ovariectomy

  2. Open Access 01-12-2024 | Osteoporosis | OriginalPaper

    Alamandine attenuates ovariectomy-induced osteoporosis by promoting osteogenic differentiation via AMPK/eNOS axis

    Osteoporosis is a systemic disorder of bone metabolism characterized by deterioration of bone microarchitecture, continuously decreased bone mass, increased bone fragility and elevated fracture risk [ 1 ]. Postmenopausal osteoporosis remains the …

  3. 08-09-2023 | Ovariectomy | OriginalPaper

    The unique role of bone marrow adipose tissue in ovariectomy-induced bone loss in mice

    Osteoporosis is a common systemic skeletal disease characterized by loss of bone mass and deterioration of bone microarchitecture leading to increased bone fragility and susceptibility to fractures [ 1 ]. Postmenopausal osteoporosis (PMOP), caused …

  4. Open Access 01-12-2023 | Osteoporosis | OriginalPaper

    Myrislignan targets extracellular signal-regulated kinase (ERK) and modulates mitochondrial function to dampen osteoclastogenesis and ovariectomy-induced osteoporosis

    The incidence of osteoporosis-the most common bone disease-is rapidly increasing worldwide due to increased life span and an aging population World Health Organization has recognized osteoporosis as a universal health problem. The disease mainly …

  5. Open Access 01-12-2023 | Ovariectomy | OriginalPaper

    ERK-estrogen receptor α signaling plays a role in the process of bone marrow mesenchymal stem cell-derived exosomes protecting against ovariectomy-induced bone loss

    Osteoporosis (OP) is a common bone disease characterized by decreased bone mass and impaired bone microstructure [ 1 – 3 ]. OP-associated fracture represents a significant burden to both patients’ families and society. Estrogen deficiency is …

  6. Open Access 01-12-2023 | Osteoporosis | OriginalPaper

    The beneficial effects of simultaneous supplementation of Lactobacillus reuteri and calcium fluoride nanoparticles on ovariectomy-induced osteoporosis

    Osteoporosis is one of the major life-threatening diseases that impact over 200 million people worldwide and mostly affects women [ 1 ]. This skeletal disorder is identified by diminished bone strength, low bone mass, and deterioration of bone …

  7. Open Access 01-12-2022 | Ovariectomy | OriginalPaper

    Early effects of ovariectomy on bone microstructure, bone turnover markers and mechanical properties in rats

    Mature bone requires continuous bone remodeling, which is the key mechanism to maintain normal bone mineral density (BMD). Therefore, bone formation is closely related to bone resorption and they are in a relatively balanced state in healthy …

  8. Open Access 01-12-2022 | Obesity | OriginalPaper

    Preventing ovariectomy-induced weight gain decreases tumor burden in rodent models of obesity and postmenopausal breast cancer

    Obesity is a global epidemic, affecting > 640 million adults worldwide and rates continue to rise [ 1 – 3 ]. Obesity rates are higher for women than men, and obesity is especially prevalent in women in the peri-menopausal or early postmenopausal …

  9. Open Access 01-09-2022 | Ovariectomy | OriginalPaper

    Failure of subcutaneous lipectomy to combat metabolic dysregulations in ovariectomy-induced obesity in young female rats

    White fat depots have been recognized to be not merely inert lumps: besides their well-known energy storing function, these depots are actually sites in the body made up of endocrine tissue that secretes physiologically active molecules, i.e. …

  10. 04-06-2022 | Estradiol | OriginalPaper

    Melatonin Alleviates Ovariectomy-Induced Cardiovascular Inflammation in Sedentary or Exercised Rats by Upregulating SIRT1

    We aimed to evaluate the impact of hormone replacement, melatonin, or exercise alone or their combination on oxidative damage and functional status of heart, brain, and aorta of ovariectomized (OVX) rats and to determine whether the signaling …

  11. 24-06-2021 | Ovariectomy | OriginalPaper

    Ovariectomy Affects Acute Pancreatitis in Mice

    Circulating estradiol levels have been associated with severe acute injury and higher mortality rates in critical illness [ 1 , 2 ]. In addition, changes in estradiol levels have been independently associated with mortality among critically ill …

  12. 29-04-2022 | Ovariectomy | OriginalPaper

    Exploring the impact of ovariectomy on hair growth: can ovariectomized mouse serve as a model for investigating female pattern hair loss in humans?

    Female pattern hair loss (FPHL), a type of hair disease common in pre- and postmenopausal women, is characterized by thinning of hair to O-type, mainly at the crown. Although a mouse model of this disease has recently been established, its details …

  13. 08-04-2023 | Ovariectomy | OriginalPaper

    Resveratrol prevents ovariectomy-induced bone quality deterioration by improving the microarchitectural and biophysicochemical properties of bone

    Osteoporosis is a global systemic skeletal disease characterized by low bone mass, deterioration of bone structure and composition, and increased fracture risk. Bone quality is an umbrella term explaining a set of characteristics of bone tissue …

  14. 11-03-2023 | OriginalPaper

    Effects of Ovariectomy on Learning in Rats in Health and after Early Proinflammatory Stress

    We report here studies on the effects of ovariectomy (OE) in females performed at age 35 days on the development and extinction of a conditioned fear reaction and on learning in the Morris water maze in adult rats. The behavior of OE females was …

  15. 02-02-2023 | OriginalPaper

    Effects of Ovariectomy on Anxious-Depressive Behavior in Female Rats in Normal Conditions and after Early Proinflammatory Stress

    The role of female sex hormones produced by the ovaries in the occurrence of sex-related features in the anxious-depressive behavior of rats was studied. Proinflammatory stress was created in half the cohort of rat pups by administration of …

  16. 01-02-2020 | Ovariectomy | OriginalPaper

    Changes in Inflammatory Response, Redox Status and Na+, K+-ATPase Activity in Primary Astrocyte Cultures from Female Wistar Rats Subject to Ovariectomy

    Astrocytes are dynamic glial cells that maintain brain homeostasis, particularly metabolic functions, inflammatory response, and antioxidant defense. Since menopause may be associated with brain dysfunction, in the present study, we evaluated …

  17. Open Access 01-04-2022 | Ovariectomy | OriginalPaper

    Treatment with Soluble Activin Type IIB Receptor Ameliorates Ovariectomy-Induced Bone Loss and Fat Gain in Mice

    During aging, the continuous decline in ovarian function leads to decreased secretion of sex hormones, including 17β-estradiol (E2), ultimately leading to menopause. As estrogen receptors are expressed in all different bone cell types …

  18. 01-11-2021 | Bone Defect | OriginalPaper

    In ovariectomy-induced osteoporotic rat models, BMP-2 substantially reversed an impaired alveolar bone regeneration whereas PDGF-BB failed

    Postmenopausal osteoporosis (PMOP) is considered one of the most concerning diseases among several pathologic symptoms or diseases associated with menopause, which is characterized by decreased bone mass and risk of fracture due to bone fragility …

  19. Open Access 01-12-2022 | Ovariectomy | OriginalPaper

    Jin-Tian-Ge ameliorates ovariectomy-induced bone loss in rats and modulates osteoblastogenesis and osteoclastogenesis in vitro

    Osteoporosis, which is a common and frequently occurring diseases for the aged people, are characterized by decreased bone mass, deterioration of bone micro-architecture, and fragility to bone fracture [ 1 – 3 ]. This disease has attracted more …

  20. 01-03-2020 | Ovariectomy | OriginalPaper

    Long Term Ovariectomy-Induced Osteoporosis is Associated with High Stearoyl-CoA Desaturase Indexes in Rat Femur

    Osteoporosis is characterized by a bone loss associated to an increased bone marrow adiposity; however, it is still unclear what kind of lipids are involved. Therefore, the main purpose of this study was to see if there is any local bone lipid …

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