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BMC Ophthalmology

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Open Access 01-12-2017 | Research article

Correlation of retinal nerve fibre layer and macular thickness with serum uric acid among type 2 diabetes mellitus

Authors: Munisamy-Naidu Vinuthinee-Naidu, Embong Zunaina, Anuar Azreen-Redzal, Naing Nyi-Nyi

Published in: BMC Ophthalmology | Issue 1/2017

Abstract

Background

Uric acid is a final breakdown product of purine catabolism in humans. It’s a potent antioxidant and can also act as a pro-oxidant that induces oxidative stress on the vascular endothelial cells, thus mediating progression of diabetic related diseases. Various epidemiological and experimental evidence suggest that uric acid has a role in the etiology of type 2 diabetes mellitus. We conducted a cross-sectional study to evaluate the correlation of retinal nerve fibre layer (RNFL) and macular thickness with serum uric acid in type 2 diabetic patients.

Methods

A cross-sectional study was conducted in the Eye Clinic, Hospital Universiti Sains Malaysia, Kelantan between the period of August 2013 till July 2015 involving type 2 diabetes mellitus patients with no diabetic retinopathy and with non-proliferative diabetic retinopathy (NPDR). An evaluation for RNFL and macular thickness was measured using Spectralis Heidelberg optical coherence tomography. Six ml of venous blood was taken for the measurement of serum uric acid and glycosylated haemoglobin (HbA1_C).

Results

A total of 180 diabetic patients were recruited (90 patients with no diabetic retinopathy and 90 patients with NPDR) into the study. The mean level of serum uric acid for both the groups was within normal range and there was no significance difference between the two groups. Based on gender, both male and female gender showed significantly higher level of mean serum uric acid in no diabetic retinopathy group (p = 0.004 respectively). The mean serum uric acid was significantly higher in patient with HbA1_C < 6.5% (p < 0.031). Patients with NPDR have thicker RNFL and macular thickness compared to patients with no diabetic retinopathy. However, only the RNFL thickness of the temporal quadrant and the macular thickness of the superior outer, inferior outer and temporal outer subfields were statistically significant (p = 0.038, p = 0.004, 0.033 and <0.001 respectively). There was poor correlation between RNFL and macular thickness with serum uric acid in both the groups.

Conclusion

Serum uric acid showed a poor correlation with RNFL and macular thickness among type 2 diabetic patients.

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Title: Correlation of retinal nerve fibre layer and macular thickness with serum uric acid among type 2 diabetes mellitus
Authors: Munisamy-Naidu Vinuthinee-Naidu
Embong Zunaina
Anuar Azreen-Redzal
Naing Nyi-Nyi
Publication date: 01-12-2017
Publisher: BioMed Central
Published in: BMC Ophthalmology / Issue 1/2017
Electronic ISSN: 1471-2415
DOI: https://doi.org/10.1186/s12886-017-0486-3

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Correlation of retinal nerve fibre layer and macular thickness with serum uric acid among type 2 diabetes mellitus

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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