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BMC Cancer
Published in: BMC Cancer 1/2018

Open Access 01-12-2018 | Debate

The curious case of Gαs gain-of-function in neoplasia

Authors: Giulio Innamorati, Thomas M. Wilkie, Havish S. Kantheti, Maria Teresa Valenti, Luca Dalle Carbonare, Luca Giacomello, Marco Parenti, Davide Melisi, Claudio Bassi

Published in: BMC Cancer | Issue 1/2018

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Abstract

Background

Mutations activating the α subunit of heterotrimeric Gs protein are associated with a number of highly specific pathological molecular phenotypes. One of the best characterized is the McCune Albright syndrome. The disease presents with an increased incidence of neoplasias in specific tissues.

Main body

A similar repertoire of neoplasms can develop whether mutations occur spontaneously in somatic tissues during fetal development or after birth.
Glands are the most “permissive” tissues, recently found to include the entire gastrointestinal tract. High frequency of activating Gαs mutations is associated with precise diagnoses (e.g., IPMN, Pyloric gland adenoma, pituitary toxic adenoma). Typically, most neoplastic lesions, from thyroid to pancreas, remain well differentiated but may be a precursor to aggressive cancer.

Conclusions

Here we propose the possibility that gain-of-function mutations of Gαs interfere with signals in the microenvironment of permissive tissues and lead to a transversal neoplastic phenotype.
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Metadata
Title
The curious case of Gαs gain-of-function in neoplasia
Authors
Giulio Innamorati
Thomas M. Wilkie
Havish S. Kantheti
Maria Teresa Valenti
Luca Dalle Carbonare
Luca Giacomello
Marco Parenti
Davide Melisi
Claudio Bassi
Publication date
01-12-2018
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2018
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/s12885-018-4133-z

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