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BMC Nephrology
Published in: BMC Nephrology 1/2022

Open Access 01-12-2022 | Research

Association of serum 25-hydroxy vitamin D with gait speed and handgrip strength in patients on hemodialysis

Authors: Chen Fu, Fengqin Wu, Fang Chen, Enhong Han, Yuehua Gao, Yongxing Xu

Published in: BMC Nephrology | Issue 1/2022

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Abstract

Background

Muscle dysfunction is prevalent in dialysis patients. Gait speed and handgrip strength are simple and reliable methods of assessing muscle function. Numerous observational studies have linked 25-hydroxy vitamin D[25(OH)D] status with gait speed and handgrip strength in populations without kidney diseases. This study aimed to evaluate the potential associations of 25(OH)D status with gait speed and handgrip strength in patients on hemodialysis.

Methods

In this observational cross-sectional study, demographic data, biological data, and dialysis parameters were collected. Gait speed and handgrip strength were measured. Multiple linear regression and logistic regression analysis were used to investigate the relationship of 25(OH)D status with gait speed and handgrip strength after adjusting for potential confounders.

Results

Overall, a total of 118 participants undergoing hemodialysis were included. Seventy-one (60.2%) participants were male. The median 25(OH)D status in participants was 11.58 (interquartile range: 8.51 to 15.41) ng/ml. When controlling for age, gender, dialysis vintage, and other confounders with a p-value < 0.15 in univariate analyses, 25(OH)D was significantly positively associated with gait speed (β = 0.16, 95% CI 0.05 to 0.28, p = 0.006) and handgrip strength (β = 3.83, 95% CI 1.09 to 6.56, p = 0.007).

Conclusion

Our study showed that 25(OH)D status seemed to be associated with gait speed and handgrip strength in patients on hemodialysis. However, these results were not robust. The relationships between 25(OH)D status and gait speed and handgrip should be further explored.
Appendix
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Metadata
Title
Association of serum 25-hydroxy vitamin D with gait speed and handgrip strength in patients on hemodialysis
Authors
Chen Fu
Fengqin Wu
Fang Chen
Enhong Han
Yuehua Gao
Yongxing Xu
Publication date
01-12-2022
Publisher
BioMed Central
Published in
BMC Nephrology / Issue 1/2022
Electronic ISSN: 1471-2369
DOI
https://doi.org/10.1186/s12882-022-02973-7

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