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European Journal of Applied Physiology
Published in: European Journal of Applied Physiology 4/2019

Open Access 01-04-2019 | Vitamin D Deficiency | Invited Review

Mechanisms of vitamin D on skeletal muscle function: oxidative stress, energy metabolism and anabolic state

Authors: Katarzyna Patrycja Dzik, Jan Jacek Kaczor

Published in: European Journal of Applied Physiology | Issue 4/2019

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Abstract

Purpose

This review provides a current perspective on the mechanism of vitamin D on skeletal muscle function with the emphasis on oxidative stress, muscle anabolic state and muscle energy metabolism. It focuses on several aspects related to cellular and molecular physiology such as VDR as the trigger point of vitamin D action, oxidative stress as a consequence of vitamin D deficiency.

Method

The interaction between vitamin D deficiency and mitochondrial function as well as skeletal muscle atrophy signalling pathways have been studied and clarified in the last years. To the best of our knowledge, we summarize key knowledge and knowledge gaps regarding the mechanism(s) of action of vitamin D in skeletal muscle.

Result

Vitamin D deficiency is associated with oxidative stress in skeletal muscle that influences the mitochondrial function and affects the development of skeletal muscle atrophy. Namely, vitamin D deficiency decreases oxygen consumption rate and induces disruption of mitochondrial function. These deleterious consequences on muscle may be associated through the vitamin D receptor (VDR) action. Moreover, vitamin D deficiency may contribute to the development of muscle atrophy. The possible signalling pathway triggering the expression of Atrogin-1 involves Src-ERK1/2-Akt- FOXO causing protein degradation.

Conclusion

Based on the current knowledge we propose that vitamin D deficiency results from the loss of VDR function and it could be partly responsible for the development of neurodegenerative diseases in human beings.
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Metadata
Title
Mechanisms of vitamin D on skeletal muscle function: oxidative stress, energy metabolism and anabolic state
Authors
Katarzyna Patrycja Dzik
Jan Jacek Kaczor
Publication date
01-04-2019
Publisher
Springer Berlin Heidelberg
Published in
European Journal of Applied Physiology / Issue 4/2019
Print ISSN: 1439-6319
Electronic ISSN: 1439-6327
DOI
https://doi.org/10.1007/s00421-019-04104-x

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