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Open Access 01-12-2022 | Biomarkers | Research article

Determining factors of functioning in hemodialysis patients using the international classification of functioning, disability and health

Authors: Luciana M. M. Santos, Pedro Henrique S. Figueiredo, Ana C. R. Silva, Patrícia C. Campos, Gabriele T. Gonçalves, Jaqueline de Paula C Freitas, Fidelis Antônio da Silva Junior, Jousielle Márcia Santos, Frederico L. Alves, Vanessa G. B. Rodrigues, Emílio Henrique B. Maciel, Maria Cecília S. M. Prates, Borja Sañudo, Redha Taiar, Mario Bernardo-Filho, Vanessa P. Lima, Henrique S. Costa, Vanessa A. Mendonça, Ana Cristina R. Lacerda

Published in: BMC Nephrology | Issue 1/2022

Abstract

Background

Hemodialysis (HD) treatment affects functioning, physical activity level, clinical biomarkers, and body composition. However, the association between these variables with functioning, considering International Classification of Functioning, Disability and Health (ICF) domains remains unclear. Thus, the aim of this study was to investigate the possible association between physical activity, biomarkers, and body composition with functioning in HD patients in reference to the ICF.

Methods

Eighty HD patients performed different tests grouped according to ICF domain: Body structure and function – handgrip strength (HS), 5-repetition sit-to-stand test, and 60-s sit-to-stand test (5-STS, 60-STS, respectively); Activity – short physical performance battery (SPPB); and Participation – participation scale questionnaire. Physical activity [Human Activity Profile questionnaire (HAP)], body composition (Dual-energy X-ray absorptiometry), Parathormone (PTH), and alkaline phosphatase were analyzed as possible variables associated with ICF domains. Data analyses were performed using simple and multiple regression models adjusted for age, duration of HD, and diuresis volume.

Results

In the body structure and function domain, appendicular lean mass, PTH level, and age were associated with HS (R² = 0.558); HAP and PTH were associated with 5-STS (R² = 0.263); and HAP, PTH, duration of HD, and age were associated with 60-STS (R² = 0.337). In the activity domain, HAP, PTH, alkaline phosphatase, duration of HD, age, and body fat were associated with SPPB (R² = 0.689). Finally, only HAP was associated with the participation scale (R² = 0.067).

Conclusion

Physical activity and PTH levels are determinant protagonists of functioning in all ICF domains in hemodialysis patients.

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Title: Determining factors of functioning in hemodialysis patients using the international classification of functioning, disability and health
Authors: Luciana M. M. Santos
Pedro Henrique S. Figueiredo
Ana C. R. Silva
Patrícia C. Campos
Gabriele T. Gonçalves
Jaqueline de Paula C Freitas
Fidelis Antônio da Silva Junior
Jousielle Márcia Santos
Frederico L. Alves
Vanessa G. B. Rodrigues
Emílio Henrique B. Maciel
Maria Cecília S. M. Prates
Borja Sañudo
Redha Taiar
Mario Bernardo-Filho
Vanessa P. Lima
Henrique S. Costa
Vanessa A. Mendonça
Ana Cristina R. Lacerda
Publication date: 01-12-2022
Publisher: BioMed Central
Keyword: Biomarkers
Published in: BMC Nephrology / Issue 1/2022
Electronic ISSN: 1471-2369
DOI: https://doi.org/10.1186/s12882-022-02719-5

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