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BMC Medical Imaging
Published in: BMC Medical Imaging 1/2019

Open Access 01-12-2019 | Glioma | Research article

A potential field segmentation based method for tumor segmentation on multi-parametric MRI of glioma cancer patients

Authors: Ranran Sun, Keqiang Wang, Lu Guo, Chengwen Yang, Jie Chen, Yalin Ti, Yu Sa

Published in: BMC Medical Imaging | Issue 1/2019

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Abstract

Background

Accurate segmentation of brain tumors is vital for the gross tumor volume (GTV) definition in radiotherapy. Functional MR images like apparent diffusion constant (ADC) and fractional anisotropy (FA) images can provide more comprehensive information for sensitive detection of the GTV. We synthesize anatomical and functional MRI for accurate and semi-automatic segmentation of GTVs and improvement of clinical efficiency.

Methods

Four MR image sets including T1-weighted contrast-enhanced (T1C), T2-weighted (T2), apparent diffusion constant (ADC) and fractional anisotropy (FA) images of 5 glioma patients were acquired and registered. A new potential field segmentation (PFS) method was proposed based on the concept of potential field in physics. For T1C, T2 and ADC images, global potential field segmentation (global-PFS) was used on user defined region of interest (ROI) for rough segmentation and then morphologically processed for accurate delineation of the GTV. For FA images, white matter (WM) was removed using local potential field segmentation (local-PFS), and then tumor extent was delineated with region growing and morphological methods. The individual segmentations of multi-parametric images were ensembled into a fused segmentation, considered as final GTV. GTVs were compared with manually delineated ground truth and evaluated with segmentation quality measure (Q), Dice’s similarity coefficient (DSC) and Sensitivity and Specificity.

Results

Experimental study with the five patients’ data and new method showed that, the mean values of Q, DSC, Sensitivity and Specificity were 0.80 (±0.07), 0.88 (±0.04), 0.92 (±0.01) and 0.88 (±0.05) respectively. The global-PFS used on ROIs of T1C, T2 and ADC images can avoid interferences from skull and other non-tumor areas. Similarity to local-PFS on FA images, it can also reduce the time complexity as compared with the global-PFS on whole image sets.

Conclusions

Efficient and semi-automatic segmentation of the GTV can be achieved with the new method. Combination of anatomical and functional MR images has the potential to provide new methods and ideas for target definition in radiotherapy.
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Metadata
Title
A potential field segmentation based method for tumor segmentation on multi-parametric MRI of glioma cancer patients
Authors
Ranran Sun
Keqiang Wang
Lu Guo
Chengwen Yang
Jie Chen
Yalin Ti
Yu Sa
Publication date
01-12-2019
Publisher
BioMed Central
Published in
BMC Medical Imaging / Issue 1/2019
Electronic ISSN: 1471-2342
DOI
https://doi.org/10.1186/s12880-019-0348-y

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