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BMC Infectious Diseases

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Open Access 01-12-2020 | Rhinovirus | Research article

Comparison of clinical features of acute lower respiratory tract infections in infants with RSV/HRV infection, and incidences of subsequent wheezing or asthma in childhood

Authors: Qin Ding, Lili Xu, Yun Zhu, Baoping Xu, Xiangpeng Chen, Yali Duan, Zhengde Xie, Kunling Shen

Published in: BMC Infectious Diseases | Issue 1/2020

Abstract

Background

To compare the clinical characteristics of acute lower respiratory tract infections (ALRTIs) caused by respiratory syncytial virus (RSV) and human rhinovirus (HRV) and to explore the relationship between the development of recurrent wheezing/asthma and RSV/ HRV infections in infancy.

Methods

Retrospective study was conducted to compare the clinical characteristics of acute lower respiratory tract infections (ALRTIs). Hospitalized patients with ALRTIs from March 2007 to December 2016 were screened. Single RSV cases (s-RSV), single HRV cases (s-HRV), and cases who had co-infection with the two viruses were enrolled. Follow-up was performed to determine whether either specific respiratory virus infection was related to subsequent development of recurrent wheezing/asthma.

Results

The s-RSV children were the youngest (P = 0.021), they experienced the most serious condition (P < 0.001) and respiratory failure (P < 0.001), they also required highest demand of oxygen therapy (P < 0.001). And in s-RSV group, the incidence of development of recurrent wheezing was significantly higher in subgroup with the family history of wheezing than that without (P < 0.001).

Conclusion

The s-RSV cases suffered from the worst severity of illness, respiratory failure and required highest demand of oxygen therapy. Recurrent wheezing was more common in s-RSV group with family history of wheezing than those without.

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Wright M, Piedimonte G. Respiratory syncytial virus prevention and therapy. Past, present, and future. Pediatr Pulmonol. 2011;46(4):324–7. https://doi.org/10.1002/ppul.21377.CrossRefPubMed

Miller EK, KhuriBulos N, Williams JV, Shehabi AA, Faouri S, Jundi IA, et al. Human rhinovirus C associated with wheezing in hospitalized children in the Middle East. J Clin Virol. 2009;46(1):85–9. https://doi.org/10.1016/j.jcv.2009.06.007.CrossRefPubMedPubMedCentral

Khetsuriani N, Kazerouni NN, Erdman DD, Lu X, Redd SC, Anderson LJ, et al. Prevalence of viral respiratory tract infections in children with asthma. J Allergy Clin Immunol. 2007;119(2):314–21. https://doi.org/10.1016/j.jaci.2006.08.041.CrossRefPubMed

Hall CB, Simőes EA, Anderson LJ. Clinical and epidemiologic features of respiratory syncytial virus. Curr Top Microbiol Immunol. 2013;372:39–57. https://doi.org/10.1007/978-3-642-38919-1_2.CrossRefPubMed

Tran DN, Trinh QD, Pham NT, Pham TM, Ha MT, Nguyen TQ, et al. Human rhinovirus infections in hospitalized children. Clinical, epidemiological and virological features. Epidemiol Infect. 2016;144(2):346–54. https://doi.org/10.1017/S0950268815000953.CrossRefPubMed

Xie ZD, Xiao Y, Liu CY, Hu YH, Yao Y, Yang Y, et al. Three years surveillance of viral etiology of acute lower respiratory tract infection in children from 2007 to 2010. Zhonghua Er Ke Za Zhi. 2011;49(10):745–9.PubMed

Sala KA, Moore A, Desai S, Welch K, Bhandari S, Carroll CL. Factors associated with disease severity in children with bronchiolitis. J Asthma. 2015;52(3):268–72. https://doi.org/10.3109/02770903.2014.956893.CrossRefPubMed

Homaira N, Oei JL, Mallitt KA, Abdel-Latif ME, Hilder L, Bajuk B, et al. High burden of RSV hospitalization in very young children. A data linkage study. Epidemiol Infect. 2016;144(8):1612–21. https://doi.org/10.1017/S0950268815003015.CrossRefPubMed

Homaira N, Briggs N, Pardy C, Hanly M, Oei JL, Hilder L, et al. Association between respiratory syncytial viral disease and the subsequent risk of the first episode of severe asthma in different subgroups of high-risk Australian children. a whole-of-population-based cohort study. BMJ Open. 2017;7(11):e017936. https://doi.org/10.1136/bmjopen-2017-017936.CrossRefPubMedPubMedCentral

10.

Jackson DJ, Gangnon RE, Evans MD, Roberg KA, Anderson EL, Pappas TE, et al. Wheezing rhinovirus illnesses in early life predict asthma development in high-risk children. Am J Respir Crit Care Med. 2008;178(7):667–72. https://doi.org/10.1164/rccm.200802-309OC.CrossRefPubMedPubMedCentral

11.

Zheng XY, Xu YJ, Guan WJ, Lin LF. Regional, age and respiratory-secretion-specific prevalence of respiratory viruses associated with asthma exacerbation. A literature review. Arch Virol. 2018;163(9):1–9. https://doi.org/10.1007/s00705-017-3700-y.CrossRef

12.

Abraham AM, Baraket A, Bialasiewicz S, Caniza MA, Chan PK, Cohen C, et al. Global epidemiology of non-influenza RNA respiratory viruses. Data gaps and a growing need for surveillance. Lancet Infect Dis. 2017;17(10):e320–6. https://doi.org/10.1016/S1473-3099(17)30238-4.CrossRef

13.

Backman K, Ollikainen H, Piipposavolainen E, Nuolivirta K, Korppi M. Asthma and lung function in adulthood after a viral wheezing episode in early childhood. Clin Exp Allergy. 2018;48(2):138–46. https://doi.org/10.1111/cea.13062.CrossRefPubMed

14.

Kumar RK, Foster PS, Rosenberg HF. Respiratory viral infection, epithelial cytokines, and innate lymphoid cells in asthma exacerbations. J Leukoc Biol. 2014;96(3):391–6. https://doi.org/10.1189/jlb.3RI0314-129R.CrossRefPubMedPubMedCentral

15.

Liu C, Xiao Y, Zhang J, Ren L, Li J, Xie Z, et al. Adenovirus infection in children with acute lower respiratory tract infections in Beijing, China, 2007 to 2012. BMC Infect Dis. 2015;15(1):408. https://doi.org/10.1186/s12879-015-1126-2.CrossRefPubMedPubMedCentral

16.

Larrañaga CL, Ampuero SL, Luchsinger VF, Carrión FA, Aguilar NV, Morales PR, et al. Impaired immune response in severe human lower tract respiratory infection by respiratory syncytial virus. Pediatr Infect Dis J. 2009;28(10):867–73. https://doi.org/10.1097/INF.0b013e3181a3ea71.CrossRefPubMed

17.

Jiang ZF, Hu YM. Zhu Futang practice of pediatrics. People’s Medical Publishing House. 2015;8:1255–9.

18.

Ren L, Gonzalez R, Wang Z, Xiang Z, Wang Y, Zhou H, et al. Prevalence of human respiratory viruses in adults with acute respiratory tract infections in Beijing, 2005–2007. Clin Microbiol Infect. 2009;15(12):1146–53. https://doi.org/10.1111/j.1469-0691.2009.02746.x.CrossRefPubMedPubMedCentral

19.

Guo L, Gonzalez R, Xie Z, Zhou H, Liu C, Wu C, et al. Bocavirus in children with respiratory tract infections. Emerg Infect Dis. 2011;17(9):1775–7. https://doi.org/10.3201/eid1709.110078.CrossRefPubMedPubMedCentral

20.

Hall CB, Weinberg GA, Iwane MK, Blumkin AK, Edwards KM, Staat MA, et al. The burden of respiratory syncytial virus infection in young children. N Engl J Med. 2009;360(6):588–98. https://doi.org/10.1056/NEJMoa0804877.CrossRefPubMedPubMedCentral

21.

Manoha C, Espinosa S, Aho SL, Huet F, Pothier P. Epidemiological and clinical features of hMPV, RSV and RVs infections in young children. J Clin Viro. 2007;38(3):221–6. https://doi.org/10.1016/j.jcv.2006.12.005.CrossRef

22.

Jun L. Chunyan L, Zhengde X, lili R, Baoping X, Jianwei W, et al. study of single infections and mixed infections by respiratory syncytial virus in children with acute lower respiratory tract disease. Chinese J Pract Pediatr. 2015;30(11):848–51.

23.

Sun Q, Chen Z, Huang L, Zhu C, Wang Y, Wang M, et al. A comparison of clinical features between rhinovirus and respiratory syncytial virus infection in lower respiratory tract in children. J Clin Pediatr. 2014;32(2):118–21.

24.

Martin ET, Kuypers J, Wald A, Englund JA. Multiple versus single virus respiratory infections. Viral load and clinical disease severity in hospitalized children. Influenza Other Respir Viruses. 2012;6(1):71–7. https://doi.org/10.1111/j.1750-2659.2011.00265.x.CrossRefPubMed

25.

Nascimento MS, Souza AV, Ferreira AV, Rodrigues JC, Abramovici S, Silva Filho LV. High rate of viral identification and coinfections in infants with acute bronchiolitis. Clinics. 2010;65(11):1133–7. https://doi.org/10.1590/s1807-59322010001100014.CrossRefPubMedPubMedCentral

26.

Canducci F, Debiaggi M, Sampaolo M, Marinozzi MC, Berrè S, Terulla C, et al. Two-year prospective study of single infections and co-infections by respiratory syncytial virus and viruses identified recently in infants with acute respiratory disease. J Med Virol. 2008;80(4):716–23. https://doi.org/10.1002/jmv.21108.CrossRefPubMedPubMedCentral

27.

Brand HK, De GR, Galama JM, Brouwer ML, Teuwen K, Hermans PW, et al. Infection with multiple viruses is not associated with increased disease severity in children with bronchiolitis. Pediatr Pulmonol. 2012;47(4):393–400. https://doi.org/10.1002/ppul.21552.CrossRefPubMed

28.

Petrarca L, Nenna R, Frassanito A, Pierangeli A, Leonardi S, Scagnolari C, et al. Acute bronchiolitis. Influence of viral co-infection in infants hospitalized over 12 consecutive epidemic seasons. J Med Virol. 2018;90(4):631–8. https://doi.org/10.1002/jmv.24994.CrossRefPubMed

29.

Calvo C, García-García ML, Blanco C, Vázquez MC, Frías ME, Pérez-Breña P, et al. Multiple simultaneous viral infections in infants with acute respiratory tract infections in Spain. J Clin Virol. 2008;42(3):268–72. https://doi.org/10.1016/j.jcv.2008.03.012.CrossRefPubMedPubMedCentral

30.

Aberle JH, Aberle SW, Pracher E, Hutter HP, Kundi M, Popow-Kraupp T. Single versus dual respiratory virus infections in hospitalized infants. impact on clinical course of disease and interferon-gamma response. Pediatr Infect Dis J. 2005;24(7):605–10. https://doi.org/10.1097/01.inf.0000168741.59747.2d.CrossRefPubMed

31.

Richard N, Komurianpradel F, Javouhey E, Perret M, Rajoharison A, Bagnaud A, et al. The impact of dual viral infection in infants admitted to a pediatric intensive care unit associated with severe bronchiolitis. Pediatr Infect Dis J. 2008;27(3):213–7. https://doi.org/10.1097/INF.0b013e31815b4935.CrossRefPubMed

32.

Henderson J, Hilliard TN, Sherriff A, Stalker D, Al Shammari N, Thomas HM. Hospitalization for RSV bronchiolitis before 12 months of age and subsequent asthma, atopy and wheeze. A longitudinal birth cohort study. Pediatr Allergy Immunol. 2005;16(5):386–92. https://doi.org/10.1111/j.1399-3038.2005.00298.x.CrossRefPubMed

33.

Sigurs N, Gustafsson PM, Bjarnason R, Lundberg F, Schmidt S, Sigurbergsson F, et al. Severe respiratory syncytial virus bronchiolitis in infancy and asthma and allergy at age 13. Am J Respir Crit Care Med. 2005;171(2):137–41. https://doi.org/10.1164/rccm.200406-730OC.CrossRefPubMed

34.

Sigurs N, Bjarnason R, Sigurbergsson F, Kjellman B. Respiratory syncytial virus bronchiolitis in infancy is an important risk factor for asthma and allergy at age 7. Am J Respir Crit Care Med. 2000;161(5):1501–7. https://doi.org/10.1164/ajrccm.161.5.9906076.CrossRefPubMed

35.

Kotaniemi-Syrjanen A, Vainionpaa R, Reijonen TM, Waris M, Korhonen K, Korppi M. Rhinovirus-induced wheezing in infancy--the first sign of childhood asthma? J Allergy Clin Immunol. 2003;111(1):66–71. https://doi.org/10.1067/mai.2003.33.CrossRefPubMedPubMedCentral

36.

Narita A, Nishimura N, Arakawa Y, Suzuki M, Sakamoto K, Sakamoto M, et al. Relationship between lower respiratory tract infections caused by respiratory syncytial virus and subsequent development of asthma in Japanese children. Jpn J Infect Dis. 2011;64(64):433–5.PubMed

37.

Kusel MM, de Klerk NH, Kebadze T, Vohma V, Holt PG, Johnston SL, et al. Early-life respiratory viral infections, atopic sensitization, and risk of subsequent development of persistent asthma. J Allergy Clin Immunol. 2007;119(5):1105–10. https://doi.org/10.1016/j.jaci.2006.12.669.CrossRefPubMedPubMedCentral

38.

Teeratakulpisarn J, Pientong C, Ekalaksananan T, Ruangsiripiyakul H, Uppala R. Rhinovirus infection in children hospitalized with acute bronchiolitis and its impact on subsequent wheezing or asthma. a comparison of etiologies. Asian Pac J Allergy Immunol. 2014;32(3):226–34. https://doi.org/10.12932/AP0417.32.3.2014.CrossRefPubMed

39.

Sigurs N, Bjarnason R, Sigurbergsson F, Kjellman B, Björkstén B. Asthma and immunoglobulin E antibodies after respiratory syncytial virus bronchiolitis. A prospective cohort study with matched controls. Pediatrics. 1995;95(4):500–5.PubMed

40.

Warris A, Neeleman C, Staal FJT, Preijers F, Ferwerda G, Brand HK, et al. CD4+ T-cell counts and interleukin-8 and CCL-5 plasma concentrations discriminate disease severity in children with RSV infection. Pediatr Res. 2013;73(2):187–93. https://doi.org/10.1038/pr.2012.163.CrossRefPubMed

41.

Díaz PV, Valdivia G, Gaggero AA, Bono MR, Zepeda G, Rivas M, et al. Pro-inflammatory cytokines in nasopharyngeal aspirate from hospitalized children with respiratory syncytial virus infection with or without rhinovirus bronchiolitis, and use of the cytokines as predictors of illness severity. Medicine. 2015;94(39):e1512. https://doi.org/10.1097/MD.0000000000001512.CrossRefPubMedPubMedCentral

42.

Selvaggi C, Pierangeli A, Fabiani M, Spano L, Nicolai A, Papoff P, et al. Interferon lambda 1-3 expression in infants hospitalized for RSV or HRV associated bronchiolitis. J Inf Secur. 2014;68(5):467–77. https://doi.org/10.1016/j.jinf.2013.12.010.CrossRef

43.

Nenna R, Ferrara M, Nicolai A, Pierangeli A, Scagnolari C, Papoff P, et al. Viral load in infants hospitalized for respiratory syncytial virus bronchiolitis correlates with recurrent wheezing at thirty-six-month follow-up. Pediatr Infect Dis J. 2015;34(10):1131. https://doi.org/10.1097/INF.0000000000000825.CrossRefPubMed

44.

Bai J. Study on related factors of bronchiolitis and subsequent recurrent wheezing in infants. Maternal Child Health Care China. 2014;29(27):4421–3.

45.

Kato M, Tsukagoshi H, Yoshizumi M, Saitoh M, Kozawa K, Yamada Y, et al. Different cytokine profile and eosinophil activation are involved in rhinovirus- and RS virus-induced acute exacerbation of childhood wheezing. Pediatr Allergy Immunol. 2011;22(1 Pt 2):e87–94. https://doi.org/10.1111/j.1399-3038.2010.01026.x.CrossRefPubMed

Title: Comparison of clinical features of acute lower respiratory tract infections in infants with RSV/HRV infection, and incidences of subsequent wheezing or asthma in childhood
Authors: Qin Ding
Lili Xu
Yun Zhu
Baoping Xu
Xiangpeng Chen
Yali Duan
Zhengde Xie
Kunling Shen
Publication date: 01-12-2020
Publisher: BioMed Central
Keywords: Rhinovirus
Respiratory Syncytial Virus Infection
Bronchial Asthma
Published in: BMC Infectious Diseases / Issue 1/2020
Electronic ISSN: 1471-2334
DOI: https://doi.org/10.1186/s12879-020-05094-4

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Comparison of clinical features of acute lower respiratory tract infections in infants with RSV/HRV infection, and incidences of subsequent wheezing or asthma in childhood

Abstract

Background

Methods

Results

Conclusion

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Abstract

Background

Methods

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Conclusion

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