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Open Access 01-10-2020 | Sarcopenia | Research

Prevalence of sarcopenia in community-dwelling older adults using the updated EWGSOP2 definition according to kidney function and albuminuria

The Screening for CKD among Older People across Europe (SCOPE) study

Authors: Rafael Moreno-Gonzalez, Xavier Corbella, Francesco Mattace-Raso, Lisanne Tap, Cornel Sieber, Ellen Freiberger, Tomasz Kostka, Agnieszka Guligowska, Itshak Melzer, Yehudit Melzer, Axel C. Carlsson, Johan Ärnlöv, Regina Roller-Wirnsberger, Gerhard Wirnsberger, Pedro Gil, Sara Lainez Martinez, Paolo Fabbietti, Andrea Corsonello, Fabrizia Lattanzio, Francesc Formiga, on behalf of SCOPE investigators

Published in: BMC Geriatrics | Special Issue 1/2020

Abstract

Background

Loss of muscle mass and function may be more pronounced in older adults with chronic kidney disease (CKD) and with albuminuria. Thus, we investigated the prevalence of sarcopenia among community-dwelling older adults according to kidney function and grade of albuminuria. We also explored differences in the prevalence of sarcopenia according to three different equations for the estimation of glomerular filtration rate (eGFR).

Methods

A cross-sectional analysis of 1420 community-dwelling older adults (≥75 years old) included in the SCOPE study, a multicenter prospective cohort study, was conducted. Comprehensive geriatric assessment including short physical performance battery (SPPB), handgrip strength test and bioelectrical impedance analysis (BIA) was performed. Sarcopenia was defined using the updated criteria of the European Working Group on Sarcopenia in Older People (EWGSOP2). eGFR was calculated using Berlin Initiative Study (BIS), Chronic Kidney Disease Epidemiological Collaboration (CKD-EPI) and Full Age Spectrum (FAS) equations, and urinary albumin-to-creatinine ratio (ACR) was collected to categorize CKD according to Kidney Disease Improving Global Outcomes guidelines.

Results

Median age was 79.5 years (77.0–83.0), 804 (56.6%) were women. Using EWGSOP2 definition, 150 (10.6%) participants met diagnostic criteria for sarcopenia. Moreover, 85 (6%) participants had severe sarcopenia. Sarcopenia was more prevalent in participants with more advanced stages of CKD according to BIS eq. (9.6% in stages 1 and 2 and 13.9% in stages 3a, 3b and 4, p = 0.042), and also according to CKD-EPI (9.8% vs. 14.2%, p = 0.042) and FAS although not reaching statistical signification (9.8% vs. 12.7%, p = 0.119). Thus, differences in prevalence are observed among CKD categories as estimated by different equations. Prevalence of sarcopenia was also higher with increasing albuminuria categories: 9.3% in normoalbuminuric, 13.2% in microalbuminuric and 16.8% in macroalbuminuric participants, (p = 0.019).

Conclusions

Sarcopenia is common among community-dwelling older adults, especially among those with more advanced CKD categories, with prevalence estimates differing slightly depending on the equation used for the estimation of eGFR; as well as among those with higher albuminuria categories.

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Title: Prevalence of sarcopenia in community-dwelling older adults using the updated EWGSOP2 definition according to kidney function and albuminuria
The Screening for CKD among Older People across Europe (SCOPE) study
Authors: Rafael Moreno-Gonzalez
Xavier Corbella
Francesco Mattace-Raso
Lisanne Tap
Cornel Sieber
Ellen Freiberger
Tomasz Kostka
Agnieszka Guligowska
Itshak Melzer
Yehudit Melzer
Axel C. Carlsson
Johan Ärnlöv
Regina Roller-Wirnsberger
Gerhard Wirnsberger
Pedro Gil
Sara Lainez Martinez
Paolo Fabbietti
Andrea Corsonello
Fabrizia Lattanzio
Francesc Formiga
on behalf of SCOPE investigators
Publication date: 01-10-2020
Publisher: BioMed Central
Keywords: Sarcopenia
Albuminuria
Chronic Kidney Disease
Published in: BMC Geriatrics / Issue Special Issue 1/2020
Electronic ISSN: 1471-2318
DOI: https://doi.org/10.1186/s12877-020-01700-x

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Prevalence of sarcopenia in community-dwelling older adults using the updated EWGSOP2 definition according to kidney function and albuminuria

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