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Published in: BMC Geriatrics 1/2018

Open Access 01-12-2018 | Research article

Validation of a one year fracture prediction tool for absolute hip fracture risk in long term care residents

Authors: Ahmed M. Negm, George Ioannidis, Micaela Jantzi, Jenn Bucek, Lora Giangregorio, Laura Pickard, John P. Hirdes, Jonathan D. Adachi, Julie Richardson, Lehana Thabane, Alexandra Papaioannou

Published in: BMC Geriatrics | Issue 1/2018

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Abstract

Background

Frail older adults living in long term care (LTC) homes have a high fracture risk, which can result in reduced quality of life, pain and death. The Fracture Risk Scale (FRS) was designed for fracture risk assessment in LTC, to optimize targeting of services in those at highest risk. This study aims to examine the construct validity and discriminative properties of the FRS in three Canadian provinces at 1-year follow up.

Methods

LTC residents were included if they were: 1) Adults admitted to LTC homes in Ontario (ON), British Columbia (BC) and Manitoba (MB) Canada; and 2) Received a Resident Assessment Instrument Minimum Data Set Version 2.0. After admission to LTC, one-year hip fracture risk was evaluated for all the included residents using the FRS (an eight-level risk scale, level 8 represents the highest fracture risk). Multiple logistic regressions were used to determine the differences in incident hip or all clinical fractures across the provinces and FRS risk levels. We examined the differences in incident hip or all clinical fracture for each FRS level across the three provinces (adjusted for age, BMI, gender, fallers and previous fractures). We used the C-statistic to assess the discriminative properties of the FRS for each province.

Results

Descriptive statistics on the LTC populations in ON (n = 29,848), BC (n = 3129), and MB (n = 2293) are: mean (SD) age 82 (10), 83 (10), and 84 (9), gender (female %) 66, 64, and 70% respectively. The incident hip fractures and all clinical fractures for FRS risk level were similar among the three provinces and ranged from 0.5 to 19.2% and 1 to 19.2% respectively. The overall discriminative properties of the FRS were similar between ON (C-statistic = 0.673), BC (C-statistic = 0.644) and MB (C-statistic = 0.649) samples.

Conclusion

FRS is a valid tool for identifying LTC residents at different risk levels for hip or all clinical fractures in three provinces. Having a fracture risk assessment tool that is tailored to the LTC context and embedded within the routine clinical assessment may have significant implications for policy, service delivery and care planning, and may improve care for LTC residents across Canada.
Literature
1.
go back to reference Canada S. Living arrangements of seniors. Census in brief No. 4.; 2011. Canada S. Living arrangements of seniors. Census in brief No. 4.; 2011.
2.
go back to reference Abellan van Kan G, Rolland Y, Houles M, Gillette-Guyonnet S, Soto M, Vellas B. The assessment of frailty in older adults. Clin Geriatr Med. 2010;26(2):275–86.CrossRef Abellan van Kan G, Rolland Y, Houles M, Gillette-Guyonnet S, Soto M, Vellas B. The assessment of frailty in older adults. Clin Geriatr Med. 2010;26(2):275–86.CrossRef
3.
go back to reference Bergman H, Ferrucci L, Guralnik J, Hogan DB, Hummel S, Karunananthan S, et al. Frailty: an emerging research and clinical paradigm--issues and controversies. J Gerontol A Biol Sci Med Sci. 2007;62(7):731–7.CrossRef Bergman H, Ferrucci L, Guralnik J, Hogan DB, Hummel S, Karunananthan S, et al. Frailty: an emerging research and clinical paradigm--issues and controversies. J Gerontol A Biol Sci Med Sci. 2007;62(7):731–7.CrossRef
4.
go back to reference Papaioannou A, Kennedy CC, Ioannidis G, Cameron C, Croxford R, Adachi JD, et al. Comparative trends in incident fracture rates for all long-term care and community-dwelling seniors in Ontario, Canada, 2002-2012. Osteoporos Int. 2016;27(3):887–97.CrossRef Papaioannou A, Kennedy CC, Ioannidis G, Cameron C, Croxford R, Adachi JD, et al. Comparative trends in incident fracture rates for all long-term care and community-dwelling seniors in Ontario, Canada, 2002-2012. Osteoporos Int. 2016;27(3):887–97.CrossRef
5.
go back to reference Tarride JE, Burke N, Leslie WD, Morin SN, Adachi JD, Papaioannou A, et al. Loss of health related quality of life following low-trauma fractures in the elderly. BMC Geriatr. 2016;16:84.CrossRef Tarride JE, Burke N, Leslie WD, Morin SN, Adachi JD, Papaioannou A, et al. Loss of health related quality of life following low-trauma fractures in the elderly. BMC Geriatr. 2016;16:84.CrossRef
6.
go back to reference Ronald LA, McGregor MJ, McGrail KM, Tate RB, Broemling AM. Hospitalization rates of nursing home residents and community-dwelling seniors in British Columbia. Can J Aging. 2008;27(1):109–15.CrossRef Ronald LA, McGregor MJ, McGrail KM, Tate RB, Broemling AM. Hospitalization rates of nursing home residents and community-dwelling seniors in British Columbia. Can J Aging. 2008;27(1):109–15.CrossRef
7.
go back to reference Dyer SM, Crotty M, Fairhall N, Magaziner J, Beaupre LA, Cameron ID, et al. A critical review of the long-term disability outcomes following hip fracture. BMC Geriatr. 2016;16:158.CrossRef Dyer SM, Crotty M, Fairhall N, Magaziner J, Beaupre LA, Cameron ID, et al. A critical review of the long-term disability outcomes following hip fracture. BMC Geriatr. 2016;16:158.CrossRef
8.
go back to reference Beaupre LA, Jones CA, Johnston DW, Wilson DM, Majumdar SR. Recovery of function following a hip fracture in geriatric ambulatory persons living in nursing homes: prospective cohort study. J Am Geriatr Soc. 2012;60(7):1268–73.CrossRef Beaupre LA, Jones CA, Johnston DW, Wilson DM, Majumdar SR. Recovery of function following a hip fracture in geriatric ambulatory persons living in nursing homes: prospective cohort study. J Am Geriatr Soc. 2012;60(7):1268–73.CrossRef
9.
go back to reference Doupe M, St John P, Chateau D, Strang D, Smele S, Bozat-Emre S, et al. Profiling the multidimensional needs of new nursing home residents: evidence to support planning. J Am Med Dir Assoc. 2012;13(5):487 e9–17.CrossRef Doupe M, St John P, Chateau D, Strang D, Smele S, Bozat-Emre S, et al. Profiling the multidimensional needs of new nursing home residents: evidence to support planning. J Am Med Dir Assoc. 2012;13(5):487 e9–17.CrossRef
10.
go back to reference A B. An Overview of Long-Term Care in Canada and Selected Provinces and Territories.; 2007. A B. An Overview of Long-Term Care in Canada and Selected Provinces and Territories.; 2007.
11.
go back to reference Siminoski K, Leslie WD, Frame H, Hodsman A, Josse RG, Khan A, et al. Recommendations for bone mineral density reporting in Canada: a shift to absolute fracture risk assessment. J Clin Densitom. 2007;10(2):120–3.CrossRef Siminoski K, Leslie WD, Frame H, Hodsman A, Josse RG, Khan A, et al. Recommendations for bone mineral density reporting in Canada: a shift to absolute fracture risk assessment. J Clin Densitom. 2007;10(2):120–3.CrossRef
12.
go back to reference Siminoski K, Leslie WD, Frame H, Hodsman A, Josse RG, Khan A, et al. Recommendations for bone mineral density reporting in Canada. Can Assoc Radiol J. 2005;56(3):178–88.PubMed Siminoski K, Leslie WD, Frame H, Hodsman A, Josse RG, Khan A, et al. Recommendations for bone mineral density reporting in Canada. Can Assoc Radiol J. 2005;56(3):178–88.PubMed
13.
go back to reference Kanis JA, Johnell O, De Laet C, Johansson H, Oden A, Delmas P, et al. A meta-analysis of previous fracture and subsequent fracture risk. Bone. 2004;35(2):375–82.CrossRef Kanis JA, Johnell O, De Laet C, Johansson H, Oden A, Delmas P, et al. A meta-analysis of previous fracture and subsequent fracture risk. Bone. 2004;35(2):375–82.CrossRef
14.
go back to reference Leslie WD, Lix LM, Langsetmo L, Berger C, Goltzman D, Hanley DA, et al. Construction of a FRAX(R) model for the assessment of fracture probability in Canada and implications for treatment. Osteoporos Int. 2011;22(3):817–27.CrossRef Leslie WD, Lix LM, Langsetmo L, Berger C, Goltzman D, Hanley DA, et al. Construction of a FRAX(R) model for the assessment of fracture probability in Canada and implications for treatment. Osteoporos Int. 2011;22(3):817–27.CrossRef
15.
go back to reference Bravo G, Dubois MF, De Wals P, Hebert R, Messier L. Relationship between regulatory status, quality of care, and three-year mortality in Canadian residential care facilities: a longitudinal study. Health Serv Res. 2002;37(5):1181–96.CrossRef Bravo G, Dubois MF, De Wals P, Hebert R, Messier L. Relationship between regulatory status, quality of care, and three-year mortality in Canadian residential care facilities: a longitudinal study. Health Serv Res. 2002;37(5):1181–96.CrossRef
16.
go back to reference Living arrangements of seniors. Catalogue no. 98–312-X2011003: Statistics Canada; 2011. Living arrangements of seniors. Catalogue no. 98–312-X2011003: Statistics Canada; 2011.
17.
go back to reference Jones AL, Dwyer LL, Bercovitz AR, Strahan GW. The National Nursing Home Survey: 2004 overview. Vital Health Stat 13. 2009(167):1–155. Jones AL, Dwyer LL, Bercovitz AR, Strahan GW. The National Nursing Home Survey: 2004 overview. Vital Health Stat 13. 2009(167):1–155.
18.
go back to reference Leslie WD, Majumdar SR, Morin SN, Lix LM, Johansson H, Oden A, et al. FRAX for fracture prediction shorter and longer than 10 years: the Manitoba BMD registry. Osteoporos Int. 2017;28(9):2557–64.CrossRef Leslie WD, Majumdar SR, Morin SN, Lix LM, Johansson H, Oden A, et al. FRAX for fracture prediction shorter and longer than 10 years: the Manitoba BMD registry. Osteoporos Int. 2017;28(9):2557–64.CrossRef
19.
go back to reference Cox L, Kloseck M, Crilly R, McWilliam C, Diachun L. Underrepresentation of individuals 80 years of age and older in chronic disease clinical practice guidelines. Can Fam Physician. 2011;57(7):e263–9.PubMedPubMedCentral Cox L, Kloseck M, Crilly R, McWilliam C, Diachun L. Underrepresentation of individuals 80 years of age and older in chronic disease clinical practice guidelines. Can Fam Physician. 2011;57(7):e263–9.PubMedPubMedCentral
20.
go back to reference Mutasingwa DR, Ge H, Upshur RE. How applicable are clinical practice guidelines to elderly patients with comorbidities? Can Fam Physician. 2011;57(7):e253–62.PubMedPubMedCentral Mutasingwa DR, Ge H, Upshur RE. How applicable are clinical practice guidelines to elderly patients with comorbidities? Can Fam Physician. 2011;57(7):e253–62.PubMedPubMedCentral
21.
go back to reference Ioannidis G, Jantzi M, Bucek J, Adachi JD, Giangregorio L, Hirdes J, et al. Development and validation of the fracture risk scale (FRS) that predicts fracture over a 1-year time period in institutionalised frail older people living in Canada: an electronic record-linked longitudinal cohort study. BMJ Open. 2017;7(9):e016477.CrossRef Ioannidis G, Jantzi M, Bucek J, Adachi JD, Giangregorio L, Hirdes J, et al. Development and validation of the fracture risk scale (FRS) that predicts fracture over a 1-year time period in institutionalised frail older people living in Canada: an electronic record-linked longitudinal cohort study. BMJ Open. 2017;7(9):e016477.CrossRef
22.
go back to reference Morris JN, Nonemaker S, Murphy K, Hawes C, Fries BE, Mor V, et al. A commitment to change: revision of HCFA's RAI. J Am Geriatr Soc. 1997;45(8):1011–6.CrossRef Morris JN, Nonemaker S, Murphy K, Hawes C, Fries BE, Mor V, et al. A commitment to change: revision of HCFA's RAI. J Am Geriatr Soc. 1997;45(8):1011–6.CrossRef
23.
go back to reference Hawes C, Morris JN, Phillips CD, Fries BE, Murphy K, Mor V. Development of the nursing home resident assessment instrument in the USA. Age Ageing. 1997;26(Suppl 2):19–25.CrossRef Hawes C, Morris JN, Phillips CD, Fries BE, Murphy K, Mor V. Development of the nursing home resident assessment instrument in the USA. Age Ageing. 1997;26(Suppl 2):19–25.CrossRef
24.
go back to reference Hirdes JP, Ljunggren G, Morris JN, Frijters DH, Finne Soveri H, Gray L, et al. Reliability of the interRAI suite of assessment instruments: a 12-country study of an integrated health information system. BMC Health Serv Res. 2008;8:277.CrossRef Hirdes JP, Ljunggren G, Morris JN, Frijters DH, Finne Soveri H, Gray L, et al. Reliability of the interRAI suite of assessment instruments: a 12-country study of an integrated health information system. BMC Health Serv Res. 2008;8:277.CrossRef
25.
go back to reference Debray TP, Vergouwe Y, Koffijberg H, Nieboer D, Steyerberg EW, Moons KG. A new framework to enhance the interpretation of external validation studies of clinical prediction models. J Clin Epidemiol. 2015;68(3):279–89.CrossRef Debray TP, Vergouwe Y, Koffijberg H, Nieboer D, Steyerberg EW, Moons KG. A new framework to enhance the interpretation of external validation studies of clinical prediction models. J Clin Epidemiol. 2015;68(3):279–89.CrossRef
26.
go back to reference Mokkink LB, Terwee CB, Patrick DL, Alonso J, Stratford PW, Knol DL, et al. The COSMIN study reached international consensus on taxonomy, terminology, and definitions of measurement properties for health-related patient-reported outcomes. J Clin Epidemiol. 2010;63(7):737–45.CrossRef Mokkink LB, Terwee CB, Patrick DL, Alonso J, Stratford PW, Knol DL, et al. The COSMIN study reached international consensus on taxonomy, terminology, and definitions of measurement properties for health-related patient-reported outcomes. J Clin Epidemiol. 2010;63(7):737–45.CrossRef
27.
go back to reference Hirdes JP, Mitchell L, Maxwell CJ, White N. Beyond the 'iron lungs of gerontology': using evidence to shape the future of nursing homes in Canada. Can J Aging. 2011;30(3):371–90.CrossRef Hirdes JP, Mitchell L, Maxwell CJ, White N. Beyond the 'iron lungs of gerontology': using evidence to shape the future of nursing homes in Canada. Can J Aging. 2011;30(3):371–90.CrossRef
31.
go back to reference O’Donnell S, Canadian Chronic Disease Surveillance System Osteoporosis Working G. Use of administrative data for national surveillance of osteoporosis and related fractures in Canada: results from a feasibility study. Archives of osteoporosis. 2013;8:143-. O’Donnell S, Canadian Chronic Disease Surveillance System Osteoporosis Working G. Use of administrative data for national surveillance of osteoporosis and related fractures in Canada: results from a feasibility study. Archives of osteoporosis. 2013;8:143-.
32.
go back to reference Steyerberg EW, Vickers AJ, Cook NR, Gerds T, Gonen M, Obuchowski N, et al. Assessing the performance of prediction models: a framework for traditional and novel measures. Epidemiology. 2010;21(1):128–38.CrossRef Steyerberg EW, Vickers AJ, Cook NR, Gerds T, Gonen M, Obuchowski N, et al. Assessing the performance of prediction models: a framework for traditional and novel measures. Epidemiology. 2010;21(1):128–38.CrossRef
33.
go back to reference EW S. Clinical prediction models: a practical approach to development, validation, and updating. New York: Springer; 2009. EW S. Clinical prediction models: a practical approach to development, validation, and updating. New York: Springer; 2009.
34.
go back to reference Onder G, Carpenter I, Finne-Soveri H, Gindin J, Frijters D, Henrard JC, et al. Assessment of nursing home residents in Europe: the services and health for elderly in long TERm care (SHELTER) study. BMC Health Serv Res. 2012;12:5.CrossRef Onder G, Carpenter I, Finne-Soveri H, Gindin J, Frijters D, Henrard JC, et al. Assessment of nursing home residents in Europe: the services and health for elderly in long TERm care (SHELTER) study. BMC Health Serv Res. 2012;12:5.CrossRef
35.
go back to reference Chamberlain SA, Gruneir A, Hoben M, Squires JE, Cummings GG, Estabrooks CA. Influence of organizational context on nursing home staff burnout: a cross-sectional survey of care aides in Western Canada. Int J Nurs Stud. 2017;71:60–9.CrossRef Chamberlain SA, Gruneir A, Hoben M, Squires JE, Cummings GG, Estabrooks CA. Influence of organizational context on nursing home staff burnout: a cross-sectional survey of care aides in Western Canada. Int J Nurs Stud. 2017;71:60–9.CrossRef
36.
go back to reference Bowers BJ, Esmond S, Jacobson N. The relationship between staffing and quality in long-term care facilities: exploring the views of nurse aides. J Nurs Care Qual. 2000;14(4):55–64 quiz 73-5.CrossRef Bowers BJ, Esmond S, Jacobson N. The relationship between staffing and quality in long-term care facilities: exploring the views of nurse aides. J Nurs Care Qual. 2000;14(4):55–64 quiz 73-5.CrossRef
37.
go back to reference Papaioannou A, Santesso N, Morin SN, Feldman S, Adachi JD, Crilly R, et al. Recommendations for preventing fracture in long-term care. CMAJ. 2015;187(15):1135–44 E450-61.CrossRef Papaioannou A, Santesso N, Morin SN, Feldman S, Adachi JD, Crilly R, et al. Recommendations for preventing fracture in long-term care. CMAJ. 2015;187(15):1135–44 E450-61.CrossRef
38.
go back to reference Wall M, Lohfeld L, Giangregorio L, Ioannidis G, Kennedy CC, Moser A, et al. Fracture risk assessment in long-term care: a survey of long-term care physicians. BMC Geriatr. 2013;13:109.CrossRef Wall M, Lohfeld L, Giangregorio L, Ioannidis G, Kennedy CC, Moser A, et al. Fracture risk assessment in long-term care: a survey of long-term care physicians. BMC Geriatr. 2013;13:109.CrossRef
39.
go back to reference Kennedy CC, Ioannidis G, Thabane L, Adachi JD, O'Donnell D, Giangregorio LM, et al. Osteoporosis prescribing in long-term care: impact of a provincial knowledge translation strategy. Can J Aging. 2015;34(2):137–48.CrossRef Kennedy CC, Ioannidis G, Thabane L, Adachi JD, O'Donnell D, Giangregorio LM, et al. Osteoporosis prescribing in long-term care: impact of a provincial knowledge translation strategy. Can J Aging. 2015;34(2):137–48.CrossRef
40.
go back to reference Jachna CM, Shireman TI, Whittle J, Ellerbeck EF, Rigler SK. Differing patterns of antiresorptive pharmacotherapy in nursing facility residents and community dwellers. J Am Geriatr Soc. 2005;53(8):1275–81.CrossRef Jachna CM, Shireman TI, Whittle J, Ellerbeck EF, Rigler SK. Differing patterns of antiresorptive pharmacotherapy in nursing facility residents and community dwellers. J Am Geriatr Soc. 2005;53(8):1275–81.CrossRef
41.
go back to reference Kennedy CC, Ioannidis G, Thabane L, Adachi JD, Marr S, Giangregorio LM, et al. Successful knowledge translation intervention in long-term care: final results from the vitamin D and osteoporosis study (ViDOS) pilot cluster randomized controlled trial. Trials. 2015;16:214.CrossRef Kennedy CC, Ioannidis G, Thabane L, Adachi JD, Marr S, Giangregorio LM, et al. Successful knowledge translation intervention in long-term care: final results from the vitamin D and osteoporosis study (ViDOS) pilot cluster randomized controlled trial. Trials. 2015;16:214.CrossRef
42.
go back to reference Colon-Emeric CS, Lyles KW, House P, Levine DA, Schenck AP, Allison J, et al. Randomized trial to improve fracture prevention in nursing home residents. Am J Med. 2007;120(10):886–92.CrossRef Colon-Emeric CS, Lyles KW, House P, Levine DA, Schenck AP, Allison J, et al. Randomized trial to improve fracture prevention in nursing home residents. Am J Med. 2007;120(10):886–92.CrossRef
43.
go back to reference Giangregorio LM, Jantzi M, Papaioannou A, Hirdes J, Maxwell CJ, Poss JW. Osteoporosis management among residents living in long-term care. Osteoporos Int. 2009;20(9):1471–8.CrossRef Giangregorio LM, Jantzi M, Papaioannou A, Hirdes J, Maxwell CJ, Poss JW. Osteoporosis management among residents living in long-term care. Osteoporos Int. 2009;20(9):1471–8.CrossRef
44.
go back to reference Alamri SH, Kennedy CC, Marr S, Lohfeld L, Skidmore CJ, Papaioannou A. Strategies to overcome barriers to implementing osteoporosis and fracture prevention guidelines in long-term care: a qualitative analysis of action plans suggested by front line staff in Ontario. Canada BMC Geriatr. 2015;15:94.CrossRef Alamri SH, Kennedy CC, Marr S, Lohfeld L, Skidmore CJ, Papaioannou A. Strategies to overcome barriers to implementing osteoporosis and fracture prevention guidelines in long-term care: a qualitative analysis of action plans suggested by front line staff in Ontario. Canada BMC Geriatr. 2015;15:94.CrossRef
45.
go back to reference OECD, Union E. A Good Life in Old Age?2013. OECD, Union E. A Good Life in Old Age?2013.
Metadata
Title
Validation of a one year fracture prediction tool for absolute hip fracture risk in long term care residents
Authors
Ahmed M. Negm
George Ioannidis
Micaela Jantzi
Jenn Bucek
Lora Giangregorio
Laura Pickard
John P. Hirdes
Jonathan D. Adachi
Julie Richardson
Lehana Thabane
Alexandra Papaioannou
Publication date
01-12-2018
Publisher
BioMed Central
Published in
BMC Geriatrics / Issue 1/2018
Electronic ISSN: 1471-2318
DOI
https://doi.org/10.1186/s12877-018-1010-1

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