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Published in: BMC Cardiovascular Disorders 1/2021

Open Access 01-12-2021 | Transthoracic Echocardiography | Research article

The evaluation of annuloplasty in bicuspid aortic valve repair using cardiac magnetic resonance

Authors: Marek J. Jasinski, Karol Miszalski-Jamka, Kinga Kosiorowska, Radoslaw Gocol, Izabella Wenzel-Jasinska, Grzegorz Bielicki, Mikolaj Berezowski, Marceli Lukaszewski, Andrzej Kansy, Marek A. Deja

Published in: BMC Cardiovascular Disorders | Issue 1/2021

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Abstract

Background

The incompetent bicuspid aortic valve (BAV) can be replaced or repaired using various surgical techniques. This study sought to assess the efficacy of external annuloplasty and postoperative reverse remodelling using cardiac magnetic resonance (CMR) and compare the results of external and subcommissural annuloplasty.

Methods

Out of a total of 200 BAV repair performed between 2004 and 2018, 21 consecutive patients (median age 54 years) with regurgitation requiring valve repair with annuloplasty without concomitant aortic root surgery were prospectively referred for CMR and transthoracic echocardiography (TTE) one year after the operation. Two aortic annulus stabilization techniques were used: external, circumferential annuloplasty (EA), and subcommissural annuloplasty (SCA).

Results

11 patients received EA and 10 patients were treated using SCA. There was no in-hospital mortality and all patients survived the follow-up period (median: 12.6 months (first quartile: 6.6; third quartile: 14.1). CMR showed strong correlation between postoperative aortic recurrent regurgitant fraction and left ventricular end-diastolic volume (r = 0.62; p = 0.003) as well as left ventricular ejection fraction (r = -0.53; p = 0.01). Patients treated with EA as compared with SCA had larger anatomic aortic valve area measured by CMR (3.5 (2.5; 4.0) vs. 2.5 cm2 (2.0; 3.4); p = 0.04). In both EA and SCA group, aortic valve area below 3.5 cm2 correlated with no regurgitation recurrency. EA (vs. SCA) was associated with lower peak transvalvular aortic gradients (10 (6; 17) vs. 21 mmHg (15; 27); p = 0.04).

Conclusions

The repair of the bicuspid aortic valve provides significant postoperative reverse remodelling, provided no recurrent regurgitation and durable reduction annuloplasty can be achieved. EA is associated with lower transvalvular gradients and higher aortic valve area assessed by CMR, compared to SCA.
Literature
1.
go back to reference Caceres M, Ma Y, Rankin JS, Saha-Chaudhuri P, Gammie JS, Suri RM, et al. Evolving practice trends of aortic root surgery in North America. Ann Thorac Surg. 2014;S0003–4975(14):01632–4. Caceres M, Ma Y, Rankin JS, Saha-Chaudhuri P, Gammie JS, Suri RM, et al. Evolving practice trends of aortic root surgery in North America. Ann Thorac Surg. 2014;S0003–4975(14):01632–4.
2.
go back to reference Schäfers H-J. Reconstruction of the bicuspid aortic valve. Op Tech Thorac Cardiovasc Surg. 2007;12:2–13.CrossRef Schäfers H-J. Reconstruction of the bicuspid aortic valve. Op Tech Thorac Cardiovasc Surg. 2007;12:2–13.CrossRef
3.
go back to reference Aicher D, Langer F, Adam O, Tscholl D, Lausberg H, Schäfers H-J. Cusp repair in aortic valve reconstruction: Does the technique affect stability? J Thorac Cardiovasc Surg. 2007;134:1533–9.CrossRef Aicher D, Langer F, Adam O, Tscholl D, Lausberg H, Schäfers H-J. Cusp repair in aortic valve reconstruction: Does the technique affect stability? J Thorac Cardiovasc Surg. 2007;134:1533–9.CrossRef
4.
go back to reference Chiappini B, Pouleur A-C, Noirhomme P, Funken JC, Astarci V, Poncelet A, el Khoury G. Repair of trileaflet aortic valve prolapse: mid-term outcome in patients with normal aortic root morphology. Interact CardioVasc Thorac Surg. 2007;6:56–9.CrossRef Chiappini B, Pouleur A-C, Noirhomme P, Funken JC, Astarci V, Poncelet A, el Khoury G. Repair of trileaflet aortic valve prolapse: mid-term outcome in patients with normal aortic root morphology. Interact CardioVasc Thorac Surg. 2007;6:56–9.CrossRef
5.
go back to reference Price J, de Kerchove L, el Khoury G. Aortic valve repair for leaflet prolapse. Sem In Thoracic and Cardiovasc Surg. 2011;23:149–51.CrossRef Price J, de Kerchove L, el Khoury G. Aortic valve repair for leaflet prolapse. Sem In Thoracic and Cardiovasc Surg. 2011;23:149–51.CrossRef
6.
go back to reference el Khoury G, Glineur D, Rubay J, Verhelst R, d’Acoz Yd, Roncelet A, et al. Functional classification of aortic root/valve abnormalities and their corelation with etiologies and surgical procedures. Curr Opin Cardiol. 2005; 20115–21. el Khoury G, Glineur D, Rubay J, Verhelst R, d’Acoz Yd, Roncelet A, et al. Functional classification of aortic root/valve abnormalities and their corelation with etiologies and surgical procedures. Curr Opin Cardiol. 2005; 20115–21.
7.
go back to reference Boodhwani M, de Kerchove L, Glineur D, Poncelet A, Rubay J, Astarci P, et al. Repair–orientated classification of aortic insufficiency: impact on surgical techniques and clinical outcomes. J Thorac Cardiovasc Surg. 2009;137:286–94.CrossRef Boodhwani M, de Kerchove L, Glineur D, Poncelet A, Rubay J, Astarci P, et al. Repair–orientated classification of aortic insufficiency: impact on surgical techniques and clinical outcomes. J Thorac Cardiovasc Surg. 2009;137:286–94.CrossRef
8.
go back to reference Cavalcante JL, Lalude OO, Schoenhagen P, Lerakis S. Cardiovascular magnetic resonance imaging for structural and valvular heart disease interventions. JACC: Cardiovasc Interv. 2016; 9: 399–4259. Cavalcante JL, Lalude OO, Schoenhagen P, Lerakis S. Cardiovascular magnetic resonance imaging for structural and valvular heart disease interventions. JACC: Cardiovasc Interv. 2016; 9: 399–4259.
9.
go back to reference Jasinski MJ, Gocol R, Malinowski M, Hudziak D, Duraj P, Deja MA. Predictors of early and medium-term outcome of 200 consecutive aortic valve and root repairs. J Thorac Cardiovasc Surg. 2015;149(1):123–9.CrossRef Jasinski MJ, Gocol R, Malinowski M, Hudziak D, Duraj P, Deja MA. Predictors of early and medium-term outcome of 200 consecutive aortic valve and root repairs. J Thorac Cardiovasc Surg. 2015;149(1):123–9.CrossRef
10.
go back to reference Jasinski MJ, Gocol R, Scott Rankin J, Malinowskil M, Hudziak D, Deja MA. Long-term outcomes after aortic valve repair and associated aortic root reconstruction. J Heart Valve Dis. 2014;23(4):414–23.PubMed Jasinski MJ, Gocol R, Scott Rankin J, Malinowskil M, Hudziak D, Deja MA. Long-term outcomes after aortic valve repair and associated aortic root reconstruction. J Heart Valve Dis. 2014;23(4):414–23.PubMed
11.
go back to reference Perez de Arenaza D, Lees B, Flather M, Nugara F, Husebye T, Jasinski M, et al. Randomized comparison of stentless versus stented valves for aortic stenosis: effects on left ventricular mass. Circulation. 2005; 112(17): 2696–702. Perez de Arenaza D, Lees B, Flather M, Nugara F, Husebye T, Jasinski M, et al. Randomized comparison of stentless versus stented valves for aortic stenosis: effects on left ventricular mass. Circulation. 2005; 112(17): 2696–702.
12.
go back to reference Miszalski-Jamka K, Jefferies J, Mazur W, Głowacki J, Hu J, Lazar M, et al. Novel genetic triggers and genotype–phenotype correlations in patients with left ventricular noncompaction. Circ Cardiovasc Genet. 2017;10:001763.CrossRef Miszalski-Jamka K, Jefferies J, Mazur W, Głowacki J, Hu J, Lazar M, et al. Novel genetic triggers and genotype–phenotype correlations in patients with left ventricular noncompaction. Circ Cardiovasc Genet. 2017;10:001763.CrossRef
13.
go back to reference Kawel-Boehm N, Maceira A, Valsangiacomo-Buechel ER, Vogel-Claussen J, Turkbey EB, Williams R, et al. Normal values for cardiovascular magnetic resonance in adults and children. J Cardiovasc Magn Reson. 2015;17:29.CrossRef Kawel-Boehm N, Maceira A, Valsangiacomo-Buechel ER, Vogel-Claussen J, Turkbey EB, Williams R, et al. Normal values for cardiovascular magnetic resonance in adults and children. J Cardiovasc Magn Reson. 2015;17:29.CrossRef
14.
go back to reference Zoghbi WA, Adams D, Bonow RO, Enriquez-Sarano M, Foster E, Grayburn PA, et al. Recommendations for noninvasive evaluation of native valvular regurgitation. A Report from the American Society of Echocardiography Developed in Collaboration with the Society for Cardiovascular Magnetic Resonance. J Am Soc Echocardiogr. 2017; 30: 303–371. Zoghbi WA, Adams D, Bonow RO, Enriquez-Sarano M, Foster E, Grayburn PA, et al. Recommendations for noninvasive evaluation of native valvular regurgitation. A Report from the American Society of Echocardiography Developed in Collaboration with the Society for Cardiovascular Magnetic Resonance. J Am Soc Echocardiogr. 2017; 30: 303–371.
15.
go back to reference Boodhwani M, de Kerchove L, Watremez C, Glineur D, Vanoverschelde JL, Noirhomme P, El Khoury G. Assessment and repair of aortic valve cusp prolapse: implications for valve-sparing procedures. J Thorac Cardiovasc Surg. 2011;141(4):917–25.CrossRef Boodhwani M, de Kerchove L, Watremez C, Glineur D, Vanoverschelde JL, Noirhomme P, El Khoury G. Assessment and repair of aortic valve cusp prolapse: implications for valve-sparing procedures. J Thorac Cardiovasc Surg. 2011;141(4):917–25.CrossRef
16.
go back to reference Schäfers HJ, Bierbach B, Aicher D. A new approach to the assessment of aortic cusp geometry. J Thorac Cardiovasc Surg. 2006;132:436–8.CrossRef Schäfers HJ, Bierbach B, Aicher D. A new approach to the assessment of aortic cusp geometry. J Thorac Cardiovasc Surg. 2006;132:436–8.CrossRef
17.
go back to reference Kirklin JW, Barratt-Boyes BG. Ventricular septal defect and aortic incompetence. In: Kirklin JW, Barrart-Boyes BG, editors. Cardiac Surgery. NY: John Whiley and Sons; 1986. p. 657. Kirklin JW, Barratt-Boyes BG. Ventricular septal defect and aortic incompetence. In: Kirklin JW, Barrart-Boyes BG, editors. Cardiac Surgery. NY: John Whiley and Sons; 1986. p. 657.
18.
go back to reference de Kerchove L, Boodhwani M, Glineur D, Poncelet A, Rubay J, Watremez C, et al. Cusp prolapse repair in trileaflet aortic valves: free margin plication and free margin resuspension techniques. Ann Thorac Surg. 2009;88(2):455–61.CrossRef de Kerchove L, Boodhwani M, Glineur D, Poncelet A, Rubay J, Watremez C, et al. Cusp prolapse repair in trileaflet aortic valves: free margin plication and free margin resuspension techniques. Ann Thorac Surg. 2009;88(2):455–61.CrossRef
19.
go back to reference de Kerchove L, Glineur D, Poncelet A, Boodhwani M, Rubay J, Dhoore W, et al. Repair of aortic leaflet prolapse: a ten-year experience. Eur J Cardiothorac Surg. 2008;34(4):785–91.CrossRef de Kerchove L, Glineur D, Poncelet A, Boodhwani M, Rubay J, Dhoore W, et al. Repair of aortic leaflet prolapse: a ten-year experience. Eur J Cardiothorac Surg. 2008;34(4):785–91.CrossRef
20.
go back to reference David TE, Feindel CM. An aortic valve-sparing operation for patients with aortic incompetence and aneurysm of the ascending aorta. J Thorac Cardiovasc Surg. 1992;103(4):617–21.CrossRef David TE, Feindel CM. An aortic valve-sparing operation for patients with aortic incompetence and aneurysm of the ascending aorta. J Thorac Cardiovasc Surg. 1992;103(4):617–21.CrossRef
21.
go back to reference Baumgartner H, Falk V, Bax JJ, De Bonis M, Hamm C, Holm PJ, et al. 2017 ESC/EACTS Guidelines for the management of valvular heart disease. Eur Heart J. 2017;38(36):2739–91.CrossRef Baumgartner H, Falk V, Bax JJ, De Bonis M, Hamm C, Holm PJ, et al. 2017 ESC/EACTS Guidelines for the management of valvular heart disease. Eur Heart J. 2017;38(36):2739–91.CrossRef
22.
go back to reference Friedman T, Mani A, Elefteriades JA. Bicuspid aortic valve: clinical approach and scientific review of a common clinical entity. Expert Rev Cardiovasc Ther. 2008;6(2):235–48.CrossRef Friedman T, Mani A, Elefteriades JA. Bicuspid aortic valve: clinical approach and scientific review of a common clinical entity. Expert Rev Cardiovasc Ther. 2008;6(2):235–48.CrossRef
23.
go back to reference Tzemos N, Therrien J, Yip J, Thanassoulis G, Tremblay S, Jamorski MT, Webb GD, Siu SC. Outcomes in adults with bicuspid aortic valves. JAMA. 2008;300(11):1317–25.CrossRef Tzemos N, Therrien J, Yip J, Thanassoulis G, Tremblay S, Jamorski MT, Webb GD, Siu SC. Outcomes in adults with bicuspid aortic valves. JAMA. 2008;300(11):1317–25.CrossRef
24.
go back to reference Michelena HI, Desjardins VA, Avierinos JF, Russo A, Nkomo VT, Sundt TM, et al. Natural history of asymptomatic patients with normally functioning or minimally dysfunctional bicuspid aortic valve in the community. Circulation. 2008;117(21):2776–84.CrossRef Michelena HI, Desjardins VA, Avierinos JF, Russo A, Nkomo VT, Sundt TM, et al. Natural history of asymptomatic patients with normally functioning or minimally dysfunctional bicuspid aortic valve in the community. Circulation. 2008;117(21):2776–84.CrossRef
25.
go back to reference Thanassoulis G, Yip JW, Filion K, Jamorski M, Webb G, Siu SC, Therrien J. Retrospective study to identify predictors of the presence and rapid progression of aortic dilatation in patients with bicuspid aortic valves. Nat Clin Pract Cardiovasc Med. 2008;5(12):821–8.CrossRef Thanassoulis G, Yip JW, Filion K, Jamorski M, Webb G, Siu SC, Therrien J. Retrospective study to identify predictors of the presence and rapid progression of aortic dilatation in patients with bicuspid aortic valves. Nat Clin Pract Cardiovasc Med. 2008;5(12):821–8.CrossRef
26.
go back to reference Verma S, Siu SC. Aortic dilatation in patients with bicuspid aortic valve. N Engl J Med. 2014;370(20):1920–9.CrossRef Verma S, Siu SC. Aortic dilatation in patients with bicuspid aortic valve. N Engl J Med. 2014;370(20):1920–9.CrossRef
27.
go back to reference Hiratzka LF, Creager MA, Isselbacher EM, Svensson LG, Nishimura RA, Bonow RO, et al. Surgery for aortic dilatation in patients with bicuspid aortic valves: a statement of clarification from the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. J Am Coll Cardiol. 2016;67(6):724–31.CrossRef Hiratzka LF, Creager MA, Isselbacher EM, Svensson LG, Nishimura RA, Bonow RO, et al. Surgery for aortic dilatation in patients with bicuspid aortic valves: a statement of clarification from the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. J Am Coll Cardiol. 2016;67(6):724–31.CrossRef
28.
go back to reference Itagaki S, Chikwe JP, Chiang YP, Egorova NN, Adams DH. Long-term risk for aortic complications after aortic valve replacement in patients with bicuspid aortic valve versus Marfan Syndrome. J Am Coll Cardiol. 2015;65(22):2363–9.CrossRef Itagaki S, Chikwe JP, Chiang YP, Egorova NN, Adams DH. Long-term risk for aortic complications after aortic valve replacement in patients with bicuspid aortic valve versus Marfan Syndrome. J Am Coll Cardiol. 2015;65(22):2363–9.CrossRef
29.
go back to reference Navarra E, El Khoury G, Glineur D, Boodhwani M, Van Dyck M, Vanoverschelde JL, et al. Effect of annulus dimension and annuloplasty on bicuspid aortic valve repair. Eur J Cardiothorac Surg. 2013;44(2):316–22.CrossRef Navarra E, El Khoury G, Glineur D, Boodhwani M, Van Dyck M, Vanoverschelde JL, et al. Effect of annulus dimension and annuloplasty on bicuspid aortic valve repair. Eur J Cardiothorac Surg. 2013;44(2):316–22.CrossRef
30.
go back to reference Vallabhajosyula P, Komlo C, Szeto WY, Wallen TJ, Desai N, Bavaria JE. Root stabilization of the repaired bicuspid aortic valve: subcommissural annuloplasty versus root reimplantation. Ann Thorac Surg. 2014;97(4):1227–34.CrossRef Vallabhajosyula P, Komlo C, Szeto WY, Wallen TJ, Desai N, Bavaria JE. Root stabilization of the repaired bicuspid aortic valve: subcommissural annuloplasty versus root reimplantation. Ann Thorac Surg. 2014;97(4):1227–34.CrossRef
31.
go back to reference Lansac E, Di Centa I, Sleilaty G, Lejeune S, Khelil N, Berrebi A, et al. Long-term results of external aortic ring annuloplasty for aortic valve repair. Eur J Cardiothorac Surg. 2016;50(2):350–60.CrossRef Lansac E, Di Centa I, Sleilaty G, Lejeune S, Khelil N, Berrebi A, et al. Long-term results of external aortic ring annuloplasty for aortic valve repair. Eur J Cardiothorac Surg. 2016;50(2):350–60.CrossRef
32.
go back to reference Mazzitelli D, Stamm C, Rankin JS, Nöbauer C, Pirk J, Meuris B, et al. Hemodynamic outcomes of geometric ring annuloplasty for aortic valve repair: a 4-center pilot trial. J Thorac Cardiovasc Surg. 2014;148(1):168–75.CrossRef Mazzitelli D, Stamm C, Rankin JS, Nöbauer C, Pirk J, Meuris B, et al. Hemodynamic outcomes of geometric ring annuloplasty for aortic valve repair: a 4-center pilot trial. J Thorac Cardiovasc Surg. 2014;148(1):168–75.CrossRef
33.
go back to reference Svensson LG, Al Kindi AH, Vivacqua A, Pettersson GB, Gillinov AM, Mihaljevic T, et al. Long-term durability of bicuspid aortic valve repair. Ann Thorac Surg. 2014;97(5):1539–47.CrossRef Svensson LG, Al Kindi AH, Vivacqua A, Pettersson GB, Gillinov AM, Mihaljevic T, et al. Long-term durability of bicuspid aortic valve repair. Ann Thorac Surg. 2014;97(5):1539–47.CrossRef
34.
go back to reference Bannas P, Lenz A, Petersen J, Sinn M, Adam G, Reichenspurner H, Girdauskas E. Normalization of transvalvular flow patterns after bicuspid aortic valve repair: insights from four-dimensional flow cardiovascular magnetic resonance imaging. Ann Thorac Surg. 2018;106(6):e319–20.CrossRef Bannas P, Lenz A, Petersen J, Sinn M, Adam G, Reichenspurner H, Girdauskas E. Normalization of transvalvular flow patterns after bicuspid aortic valve repair: insights from four-dimensional flow cardiovascular magnetic resonance imaging. Ann Thorac Surg. 2018;106(6):e319–20.CrossRef
35.
go back to reference Zafar MA, Li Y, Rizzo JA, Charilaou P, Saeyeldin A, Velasquez CA, et al. Height alone, rather than body surface area, suffices for risk estimation in ascending aortic aneurysm. J Thorac Cardiovasc Surg. 2018;155(5):1938–50.CrossRef Zafar MA, Li Y, Rizzo JA, Charilaou P, Saeyeldin A, Velasquez CA, et al. Height alone, rather than body surface area, suffices for risk estimation in ascending aortic aneurysm. J Thorac Cardiovasc Surg. 2018;155(5):1938–50.CrossRef
36.
go back to reference Myerson SG, d’Arcy J, Mohiaddin R, Greenwood JP, Karamitsos TD, Francis JM, et al. Aortic regurgitation quantification using cardiovascular magnetic resonance: association with clinical outcome. Circulation. 2012;126(12):1452–60.CrossRef Myerson SG, d’Arcy J, Mohiaddin R, Greenwood JP, Karamitsos TD, Francis JM, et al. Aortic regurgitation quantification using cardiovascular magnetic resonance: association with clinical outcome. Circulation. 2012;126(12):1452–60.CrossRef
37.
go back to reference Ribeiro HB, Le Ven F, Larose E, Dahou A, Nombela-Franco L, Urena M, et al. Cardiac magnetic resonance versus transthoracic echocardiography for the assessment and quantification of aortic regurgitation in patients undergoing transcatheter aortic valve implantation. Heart. 2014;100(24):1924–32.CrossRef Ribeiro HB, Le Ven F, Larose E, Dahou A, Nombela-Franco L, Urena M, et al. Cardiac magnetic resonance versus transthoracic echocardiography for the assessment and quantification of aortic regurgitation in patients undergoing transcatheter aortic valve implantation. Heart. 2014;100(24):1924–32.CrossRef
38.
go back to reference Youssefi P, Gomez A, He T, Anderson L, Bunce N, Sharma R, et al. Patient-specific computational fluid dynamics-assessment of aortic hemodynamics in a spectrum of aortic valve pathologies. J Thorac Cardiovasc Surg. 2017;153(1):8-20.e3.CrossRef Youssefi P, Gomez A, He T, Anderson L, Bunce N, Sharma R, et al. Patient-specific computational fluid dynamics-assessment of aortic hemodynamics in a spectrum of aortic valve pathologies. J Thorac Cardiovasc Surg. 2017;153(1):8-20.e3.CrossRef
39.
go back to reference Bellenger NG, Davies LC, Francis JM, Coats AJ, Pennell DJ. Reduction in sample size for studies of remodeling in heart failure by the use of cardiovascular magnetic resonance. J Cardiovasc Magn Reson. 2000;2(4):271–8.CrossRef Bellenger NG, Davies LC, Francis JM, Coats AJ, Pennell DJ. Reduction in sample size for studies of remodeling in heart failure by the use of cardiovascular magnetic resonance. J Cardiovasc Magn Reson. 2000;2(4):271–8.CrossRef
40.
go back to reference Cawley PJ, Hamilton-Craig C, Owens DS, Krieger EV, Strugnell WE, Mitsumori L, et al. Prospective comparison of valve regurgitation quantitation by cardiac magnetic resonance imaging and transthoracic echocardiography. Circ Cardiovasc Imaging. 2013;6(1):48–57.CrossRef Cawley PJ, Hamilton-Craig C, Owens DS, Krieger EV, Strugnell WE, Mitsumori L, et al. Prospective comparison of valve regurgitation quantitation by cardiac magnetic resonance imaging and transthoracic echocardiography. Circ Cardiovasc Imaging. 2013;6(1):48–57.CrossRef
Metadata
Title
The evaluation of annuloplasty in bicuspid aortic valve repair using cardiac magnetic resonance
Authors
Marek J. Jasinski
Karol Miszalski-Jamka
Kinga Kosiorowska
Radoslaw Gocol
Izabella Wenzel-Jasinska
Grzegorz Bielicki
Mikolaj Berezowski
Marceli Lukaszewski
Andrzej Kansy
Marek A. Deja
Publication date
01-12-2021
Publisher
BioMed Central
Published in
BMC Cardiovascular Disorders / Issue 1/2021
Electronic ISSN: 1471-2261
DOI
https://doi.org/10.1186/s12872-020-01831-4

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