Skip to main content
Top
Published in: BMC Cardiovascular Disorders 1/2020

Open Access 01-12-2020 | ST-Segment Elevation Myocardial Infarction | Research article

Heat map visualization for electrocardiogram data analysis

Authors: Haisen Guo, Weidai Zhang, Chumin Ni, Zhixiong Cai, Songming Chen, Xiansheng Huang

Published in: BMC Cardiovascular Disorders | Issue 1/2020

Login to get access

Abstract

Background

Most electrocardiogram (ECG) studies still take advantage of traditional statistical functions, and the results are mostly presented in tables, histograms, and curves. Few papers display ECG data by visual means. The aim of this study was to analyze and show data for electrocardiographic left ventricular hypertrophy (LVH) with ST-segment elevation (STE) by a heat map in order to explore the feasibility and clinical value of heat mapping for ECG data visualization.

Methods

We sequentially collected the electrocardiograms of inpatients in the First Affiliated Hospital of Shantou University Medical College from July 2015 to December 2015 in order to screen cases of LVH with STE. HemI 1.0 software was used to draw heat maps to display the STE of each lead of each collected ECG. Cluster analysis was carried out based on the heat map and the results were drawn as tree maps (pedigree maps) in the heat map.

Results

In total, 60 cases of electrocardiographic LVH with STE were screened and analyzed. STE leads were mainly in the V1, V2 and V3 leads. The ST-segment shifts of each lead of each collected ECG could be conveniently visualized in the heat map. According to cluster analysis in the heat map, STE leads were clustered into two categories, comprising of the right precordial leads (V1, V2, V3) and others (V4, V5, V6, I, II, III, aVF, aVL, aVR). Moreover, the STE amplitude in 40% (24 out of 60) of cases reached the threshold specified in the STEMI guideline. These cases also could be fully displayed and visualized in the heat map. Cluster analysis in the heat map showed that the III, aVF and aVR leads could be clustered together, the V1, V2, V3 and V4 leads could be clustered together, and the V5, V6, I and aVL leads could be clustered together.

Conclusion

Heat maps and cluster analysis can be used to fully display every lead of each electrocardiogram and provide relatively comprehensive information.
Appendix
Available only for authorised users
Literature
1.
go back to reference Mond HG. The Spectrum of ambulatory electrocardiographic monitoring. Heart Lung Circ. 2017;26(11):1160–74.CrossRef Mond HG. The Spectrum of ambulatory electrocardiographic monitoring. Heart Lung Circ. 2017;26(11):1160–74.CrossRef
2.
go back to reference Lindow T, Birnbaum Y, Nikus K, Maan A, Ekelund U, Pahlm O. Why complicate an important task? An orderly display of the limb leads in the 12-lead electrocardiogram and its implications for recognition of acute coronary syndrome. BMC Cardiovasc Disord. 2019;19(1):13.CrossRef Lindow T, Birnbaum Y, Nikus K, Maan A, Ekelund U, Pahlm O. Why complicate an important task? An orderly display of the limb leads in the 12-lead electrocardiogram and its implications for recognition of acute coronary syndrome. BMC Cardiovasc Disord. 2019;19(1):13.CrossRef
3.
go back to reference Cortez D, Baturova M, Lindgren A, Carlson J, Shubik YV, Olsson B, Platonov PG. Atrial time and voltage dispersion are both needed to predict new-onset atrial fibrillation in ischemic stroke patients. BMC Cardiovasc Disord. 2017;17(1):200.CrossRef Cortez D, Baturova M, Lindgren A, Carlson J, Shubik YV, Olsson B, Platonov PG. Atrial time and voltage dispersion are both needed to predict new-onset atrial fibrillation in ischemic stroke patients. BMC Cardiovasc Disord. 2017;17(1):200.CrossRef
4.
go back to reference Pravdic D. “who” can be found in and beyond of an electrocardiographic strip. Pacing Clin Electrophysiol. 2014;37(3):265–78.CrossRef Pravdic D. “who” can be found in and beyond of an electrocardiographic strip. Pacing Clin Electrophysiol. 2014;37(3):265–78.CrossRef
5.
go back to reference Ohannessian R, Benet T, Argaud L, Guerin C, Guichon C, Piriou V, Rimmele T, Girard R, Gerbier-Colomban S, Vanhems P. Heat map for data visualization in infection control epidemiology: an application describing the relationship between hospital-acquired infections, simplified acute physiological score II, and length of stay in adult intensive care units. Am J Infect Control. 2017;45(7):746–9.CrossRef Ohannessian R, Benet T, Argaud L, Guerin C, Guichon C, Piriou V, Rimmele T, Girard R, Gerbier-Colomban S, Vanhems P. Heat map for data visualization in infection control epidemiology: an application describing the relationship between hospital-acquired infections, simplified acute physiological score II, and length of stay in adult intensive care units. Am J Infect Control. 2017;45(7):746–9.CrossRef
6.
go back to reference Wilkinson L, Friendly M. The history of the cluster heat map. Am Stat. 2009;63(2):179–84.CrossRef Wilkinson L, Friendly M. The history of the cluster heat map. Am Stat. 2009;63(2):179–84.CrossRef
7.
go back to reference Kellom M, Raymond J. Using dendritic heat maps to simultaneously display genotype divergence with phenotype divergence. PLoS One. 2016;11(8):e0161292.CrossRef Kellom M, Raymond J. Using dendritic heat maps to simultaneously display genotype divergence with phenotype divergence. PLoS One. 2016;11(8):e0161292.CrossRef
8.
go back to reference Deng W, Wang Y, Liu Z, Cheng H, Xue Y. HemI: a toolkit for illustrating heatmaps. PLoS One. 2014;9(11):e111988.CrossRef Deng W, Wang Y, Liu Z, Cheng H, Xue Y. HemI: a toolkit for illustrating heatmaps. PLoS One. 2014;9(11):e111988.CrossRef
9.
go back to reference Devereux RB, Casale PN, Eisenberg RR, Miller DH, Kligfield P. Electrocardiographic detection of left ventricular hypertrophy using echocardiographic determination of left ventricular mass as the reference standard. Comparison of standard criteria, computer diagnosis and physician interpretation. J Am Coll Cardiol. 1984;3(1):82–7.CrossRef Devereux RB, Casale PN, Eisenberg RR, Miller DH, Kligfield P. Electrocardiographic detection of left ventricular hypertrophy using echocardiographic determination of left ventricular mass as the reference standard. Comparison of standard criteria, computer diagnosis and physician interpretation. J Am Coll Cardiol. 1984;3(1):82–7.CrossRef
10.
go back to reference Ibanez B, James S, Agewall S, Antunes MJ, Bucciarelli-Ducci C, Bueno H, Caforio ALP, Crea F, Goudevenos JA, Halvorsen S, et al. 2017 ESC guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: the task force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J. 2018;39(2):119–77.CrossRef Ibanez B, James S, Agewall S, Antunes MJ, Bucciarelli-Ducci C, Bueno H, Caforio ALP, Crea F, Goudevenos JA, Halvorsen S, et al. 2017 ESC guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: the task force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J. 2018;39(2):119–77.CrossRef
11.
go back to reference Kosuge M, Uchida K, Imoto K, Hashiyama N, Ebina T, Hibi K, Tsukahara K, Maejima N, Masuda M, Umemura S, et al. Frequency and implication of ST-T abnormalities on hospital admission electrocardiograms in patients with type a acute aortic dissection. Am J Cardiol. 2013;112(3):424–9.CrossRef Kosuge M, Uchida K, Imoto K, Hashiyama N, Ebina T, Hibi K, Tsukahara K, Maejima N, Masuda M, Umemura S, et al. Frequency and implication of ST-T abnormalities on hospital admission electrocardiograms in patients with type a acute aortic dissection. Am J Cardiol. 2013;112(3):424–9.CrossRef
12.
go back to reference Larson DM, Menssen KM, Sharkey SW, Duval S, Schwartz RS, Harris J, Meland JT, Unger BT, Henry TD. “False-positive” cardiac catheterization laboratory activation among patients with suspected ST-segment elevation myocardial infarction. Jama. 2007;298(23):2754–60.CrossRef Larson DM, Menssen KM, Sharkey SW, Duval S, Schwartz RS, Harris J, Meland JT, Unger BT, Henry TD. “False-positive” cardiac catheterization laboratory activation among patients with suspected ST-segment elevation myocardial infarction. Jama. 2007;298(23):2754–60.CrossRef
13.
go back to reference Rokos IC, French WJ, Mattu A, Nichol G, Farkouh ME, Reiffel J, Stone GW. Appropriate cardiac cath lab activation: optimizing electrocardiogram interpretation and clinical decision-making for acute ST-elevation myocardial infarction. Am Heart J. 2010;160(6):995–1003 1003.e1001–1008.CrossRef Rokos IC, French WJ, Mattu A, Nichol G, Farkouh ME, Reiffel J, Stone GW. Appropriate cardiac cath lab activation: optimizing electrocardiogram interpretation and clinical decision-making for acute ST-elevation myocardial infarction. Am Heart J. 2010;160(6):995–1003 1003.e1001–1008.CrossRef
14.
go back to reference Sokal RRM, C.D. A statistical method for evaluating systematic relationships. Univ Kansas Sci Bull. 1958;38(2):1409–38. Sokal RRM, C.D. A statistical method for evaluating systematic relationships. Univ Kansas Sci Bull. 1958;38(2):1409–38.
15.
go back to reference Thygesen K, Alpert JS, Jaffe AS, Simoons ML, Chaitman BR, White HD, Katus HA, Lindahl B, Morrow DA, Clemmensen PM, et al. Third universal definition of myocardial infarction. Circulation. 2012;126(16):2020–35.CrossRef Thygesen K, Alpert JS, Jaffe AS, Simoons ML, Chaitman BR, White HD, Katus HA, Lindahl B, Morrow DA, Clemmensen PM, et al. Third universal definition of myocardial infarction. Circulation. 2012;126(16):2020–35.CrossRef
16.
go back to reference Carroll LN, Au AP, Detwiler LT, Fu TC, Painter IS, Abernethy NF. Visualization and analytics tools for infectious disease epidemiology: a systematic review. J Biomed Inform. 2014;51:287–98.CrossRef Carroll LN, Au AP, Detwiler LT, Fu TC, Painter IS, Abernethy NF. Visualization and analytics tools for infectious disease epidemiology: a systematic review. J Biomed Inform. 2014;51:287–98.CrossRef
17.
go back to reference Matzen LE, Haass MJ, Divis KM, Wang Z, Wilson AT. Data visualization saliency model: a tool for evaluating abstract data visualizations. IEEE Trans Vis Comput Graph. 2018;24(1):563–73.CrossRef Matzen LE, Haass MJ, Divis KM, Wang Z, Wilson AT. Data visualization saliency model: a tool for evaluating abstract data visualizations. IEEE Trans Vis Comput Graph. 2018;24(1):563–73.CrossRef
18.
go back to reference Fernandez NF, Gundersen GW, Rahman A, Grimes ML, Rikova K, Hornbeck P, Ma'ayan A. Clustergrammer, a web-based heatmap visualization and analysis tool for high-dimensional biological data. Scientific Data. 2017;4:170151.CrossRef Fernandez NF, Gundersen GW, Rahman A, Grimes ML, Rikova K, Hornbeck P, Ma'ayan A. Clustergrammer, a web-based heatmap visualization and analysis tool for high-dimensional biological data. Scientific Data. 2017;4:170151.CrossRef
19.
go back to reference Shamim S, McCrary J, Wayne L, Gratton M, Bogart DB. Electrocardiograhic findings resulting in inappropriate cardiac catheterization laboratory activation for ST-segment elevation myocardial infarction. Cardiovasc Diagn Ther. 2014;4(3):215–23.PubMedPubMedCentral Shamim S, McCrary J, Wayne L, Gratton M, Bogart DB. Electrocardiograhic findings resulting in inappropriate cardiac catheterization laboratory activation for ST-segment elevation myocardial infarction. Cardiovasc Diagn Ther. 2014;4(3):215–23.PubMedPubMedCentral
20.
go back to reference Garvey JL, Monk L, Granger CB, Studnek JR, Roettig ML, Corbett CC, Jollis JG. Rates of cardiac catheterization cancelation for ST-segment elevation myocardial infarction after activation by emergency medical services or emergency physicians: results from the North Carolina catheterization laboratory activation registry. Circulation. 2012;125(2):308–13.CrossRef Garvey JL, Monk L, Granger CB, Studnek JR, Roettig ML, Corbett CC, Jollis JG. Rates of cardiac catheterization cancelation for ST-segment elevation myocardial infarction after activation by emergency medical services or emergency physicians: results from the North Carolina catheterization laboratory activation registry. Circulation. 2012;125(2):308–13.CrossRef
21.
go back to reference Lu N, Zhu JX, Yang PX, Tan XR. Models for improved diagnosis of left ventricular hypertrophy based on conventional electrocardiographic criteria. BMC Cardiovasc Disord. 2017;17(1):217.CrossRef Lu N, Zhu JX, Yang PX, Tan XR. Models for improved diagnosis of left ventricular hypertrophy based on conventional electrocardiographic criteria. BMC Cardiovasc Disord. 2017;17(1):217.CrossRef
22.
go back to reference Armstrong EJ, Kulkarni AR, Bhave PD, Hoffmayer KS, Macgregor JS, Stein JC, Kinlay S, Ganz P, McCabe JM. Electrocardiographic criteria for ST-elevation myocardial infarction in patients with left ventricular hypertrophy. Am J Cardiol. 2012;110(7):977–83.CrossRef Armstrong EJ, Kulkarni AR, Bhave PD, Hoffmayer KS, Macgregor JS, Stein JC, Kinlay S, Ganz P, McCabe JM. Electrocardiographic criteria for ST-elevation myocardial infarction in patients with left ventricular hypertrophy. Am J Cardiol. 2012;110(7):977–83.CrossRef
23.
go back to reference Shemirani H, Nayeri-Torshizi E. Electrocardiographic characteristics of posterior myocardial infarction in comparison to angiographic findings. ARYA Atherosclerosis. 2015;11(1):30–5.PubMedPubMedCentral Shemirani H, Nayeri-Torshizi E. Electrocardiographic characteristics of posterior myocardial infarction in comparison to angiographic findings. ARYA Atherosclerosis. 2015;11(1):30–5.PubMedPubMedCentral
24.
go back to reference Wu CI, Chang SL, Lin CY, Vicera JJB, Lin YJ, Lo LW, Chung FP, Hu YF, Chang TY, Chao TF, et al. Clinical significance of J wave in prediction of ventricular arrhythmia in patients with acute myocardial infarction. J Cardiol. 2019;73(5):351–7. Wu CI, Chang SL, Lin CY, Vicera JJB, Lin YJ, Lo LW, Chung FP, Hu YF, Chang TY, Chao TF, et al. Clinical significance of J wave in prediction of ventricular arrhythmia in patients with acute myocardial infarction. J Cardiol. 2019;73(5):351–7.
25.
go back to reference Boudier A, Curjuric I, Basagana X, Hazgui H, Anto JM, Bousquet J, Bridevaux PO, Dupuis-Lozeron E, Garcia-Aymerich J, Heinrich J, et al. Ten-year follow-up of cluster-based asthma phenotypes in adults. A pooled analysis of three cohorts. Am J Respir Crit Care Med. 2013;188(5):550–60.CrossRef Boudier A, Curjuric I, Basagana X, Hazgui H, Anto JM, Bousquet J, Bridevaux PO, Dupuis-Lozeron E, Garcia-Aymerich J, Heinrich J, et al. Ten-year follow-up of cluster-based asthma phenotypes in adults. A pooled analysis of three cohorts. Am J Respir Crit Care Med. 2013;188(5):550–60.CrossRef
26.
go back to reference Dunn H, Quinn L, Corbridge SJ, Eldeirawi K, Kapella M, Collins EG. Cluster analysis in nursing research: an introduction, historical perspective, and future directions. West J Nurs Res. 2018;40(11):1658–76.CrossRef Dunn H, Quinn L, Corbridge SJ, Eldeirawi K, Kapella M, Collins EG. Cluster analysis in nursing research: an introduction, historical perspective, and future directions. West J Nurs Res. 2018;40(11):1658–76.CrossRef
27.
go back to reference Driscoll T, Gabbard JL, Mao C, Dalay O, Shukla M, Freifeld CC, Hoen AG, Brownstein JS, Sobral BW. Integration and visualization of host-pathogen data related to infectious diseases. Bioinformatics (Oxford, England). 2011;27(16):2279–87.CrossRef Driscoll T, Gabbard JL, Mao C, Dalay O, Shukla M, Freifeld CC, Hoen AG, Brownstein JS, Sobral BW. Integration and visualization of host-pathogen data related to infectious diseases. Bioinformatics (Oxford, England). 2011;27(16):2279–87.CrossRef
28.
go back to reference Laguna P, Sornmo L. The STAFF III ECG database and its significance for methodological development and evaluation. J Electrocardiol. 2014;47(4):408–17.CrossRef Laguna P, Sornmo L. The STAFF III ECG database and its significance for methodological development and evaluation. J Electrocardiol. 2014;47(4):408–17.CrossRef
29.
go back to reference Silva I, Moody GB. An open-source toolbox for analysing and processing physioNet databases in MATLAB and octave. J Open Res Software. 2014;2(1):e27. Silva I, Moody GB. An open-source toolbox for analysing and processing physioNet databases in MATLAB and octave. J Open Res Software. 2014;2(1):e27.
Metadata
Title
Heat map visualization for electrocardiogram data analysis
Authors
Haisen Guo
Weidai Zhang
Chumin Ni
Zhixiong Cai
Songming Chen
Xiansheng Huang
Publication date
01-12-2020
Publisher
BioMed Central
Published in
BMC Cardiovascular Disorders / Issue 1/2020
Electronic ISSN: 1471-2261
DOI
https://doi.org/10.1186/s12872-020-01560-8

Other articles of this Issue 1/2020

BMC Cardiovascular Disorders 1/2020 Go to the issue