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Open Access 01-12-2017 | Research article

Elevated exhaled acetone concentration in stage C heart failure patients with diabetes mellitus

Authors: Tetsuro Yokokawa, Takamasa Sato, Satoshi Suzuki, Masayoshi Oikawa, Akiomi Yoshihisa, Atsushi Kobayashi, Takayoshi Yamaki, Hiroyuki Kunii, Kazuhiko Nakazato, Hitoshi Suzuki, Shu-ichi Saitoh, Takafumi Ishida, Akito Shimouchi, Yasuchika Takeishi

Published in: BMC Cardiovascular Disorders | Issue 1/2017

Abstract

Background

Breath acetone is a noninvasive biomarker of heart failure; however, its significance in heart failure patients with diabetes mellitus has yet to be clarified. The objective of this study is to investigate whether exhaled acetone concentration is a noninvasive biomarker in heart failure patients with diabetes mellitus.

Methods

This study prospectively included 35 diabetic patients with stage C heart failure and 20 diabetic patients with or at risk of heart failure (stage A or B). Exhaled breath was collected after an overnight fast.

Results

The stage C group had significantly higher brain natriuretic peptide levels, larger left ventricular diameter, lower left ventricular ejection fraction, and more frequent use of β-blocker, compared with the stage A or B group. The stage C group had higher exhaled acetone concentrations than the stage A or B group (p = 0.013). Exhaled acetone concentration was correlated with total ketone bodies (r = 0.588, p < 0.001) and brain natriuretic peptide (r = 0.415, p = 0.002).

Conclusion

Stage C heart failure patients with diabetes mellitus have elevated exhaled acetone concentrations. Exhaled acetone concentration could be a noninvasive biomarker in heart failure patients with diabetes mellitus.

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Title: Elevated exhaled acetone concentration in stage C heart failure patients with diabetes mellitus
Authors: Tetsuro Yokokawa
Takamasa Sato
Satoshi Suzuki
Masayoshi Oikawa
Akiomi Yoshihisa
Atsushi Kobayashi
Takayoshi Yamaki
Hiroyuki Kunii
Kazuhiko Nakazato
Hitoshi Suzuki
Shu-ichi Saitoh
Takafumi Ishida
Akito Shimouchi
Yasuchika Takeishi
Publication date: 01-12-2017
Publisher: BioMed Central
Published in: BMC Cardiovascular Disorders / Issue 1/2017
Electronic ISSN: 1471-2261
DOI: https://doi.org/10.1186/s12872-017-0713-0

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