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BMC Cardiovascular Disorders

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Open Access 01-12-2017 | Research article

Serum high concentrations of homocysteine and low levels of folic acid and vitamin B₁₂ are significantly correlated with the categories of coronary artery diseases

Authors: Yan Ma, Duanliang Peng, Chenggui Liu, Chen Huang, Jun Luo

Published in: BMC Cardiovascular Disorders | Issue 1/2017

Abstract

Background

Homocysteine (Hcy) has been considered as an independent risk factor for coronary artery disease (CAD). Folic acid and vitamin B₁₂ are two vital regulators in Hcy metabolic process. We evaluated the correlations between serum Hcy, folic acid and vitamin B₁₂ with the categories of CAD.

Methods

Serum Hcy, folic acid and vitamin B₁₂ from 292 CAD patients, including 73 acute myocardial infarction (AMI), 116 unstable angina pectoris (UAP), 103 stable angina pectoris (SAP), and 100 controls with chest pain patients were measured, and the data were analyzed by SPSS software.

Results

Compared to SAP patients, patients with AMI and UAP had higher Hcy levels with approximately average elevated (4-5) μmol/L, while SAP patients were approximately higher 8 μmol/L than controls. However, the levels of folic acid and vitamin B₁₂ had opposite results, which in AMI group was the lowest, while in controls was the highest. CAD categories were positively correlated with Hcy (r = 0.286, p < 0.001), and negatively correlated with folic acid (r = -0.297, p < 0.001) and vitamin B₁₂ (r = -0.208, p < 0.001). There were significant trend toward increase in the prevalence of high Hcy, low folic acid and vitamin B₁₂ from controls, to SAP, to UAP, and to AMI.

Conclusions

The present study provide the valuable evidence that high concentrations of Hcy and low levels of folic acid and vitamin B₁₂ are significantly correlated with CAD categories.

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Title: Serum high concentrations of homocysteine and low levels of folic acid and vitamin B12 are significantly correlated with the categories of coronary artery diseases
Authors: Yan Ma
Duanliang Peng
Chenggui Liu
Chen Huang
Jun Luo
Publication date: 01-12-2017
Publisher: BioMed Central
Published in: BMC Cardiovascular Disorders / Issue 1/2017
Electronic ISSN: 1471-2261
DOI: https://doi.org/10.1186/s12872-017-0475-8

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Serum high concentrations of homocysteine and low levels of folic acid and vitamin B₁₂ are significantly correlated with the categories of coronary artery diseases

Abstract

Background

Methods

Results

Conclusions

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