Skip to main content
Top
Published in: BMC Cardiovascular Disorders 1/2017

Open Access 01-12-2017 | Research article

Medical and sociodemographic factors predict persistent smoking after coronary events

Authors: Elise Sverre, Jan Erik Otterstad, Erik Gjertsen, Lars Gullestad, Einar Husebye, Toril Dammen, Torbjørn Moum, John Munkhaugen

Published in: BMC Cardiovascular Disorders | Issue 1/2017

Login to get access

Abstract

Background

Understanding the determinants of persistent smoking after a coronary event constitutes the basis of modelling interventions of smoking cessation in secondary prevention programs. We aim to identify the potentially modifiable medical, sociodemographic and psychosocial factors, comprising the study factors, associated with unfavourable risk factor control after CHD events.

Methods

A cross-sectional explorative study used logistic regression analysis to investigate the association between study factors and smoking status in 1083 patients hospitalized with myocardial infarction and/or coronary revascularization. Hospital record data, a self-report questionnaire, clinical examination and blood samples were applied.

Results

At the index hospitalization, 390 patients were smoking and at follow-up after 2–36 months 167 (43%) of these had quit, while 230 reported persistent smoking. In adjusted analyses, unemployed or disability benefits (Odds ratio (OR) 4.1), low education (OR 3.5), longer smoking duration (OR 2.3) and not having ST-elevation myocardial infarction (STEMI) as index event (OR 2.3) were significantly associated with persistent smoking. Psychosocial factors at follow-up were not associated with persistent smoking. Smokers reported high motivation for cessation, with 68% wanting help to quit. Only 42% had been offered nicotine replacement therapy or other cessation aids. Smokers rated use of tobacco as the most important cause of their coronary disease (6.8 on a 1–10 Likert scale).

Conclusions

Low socioeconomic status, prior duration of smoking, and not having STEMI as index event were associated with persisting smoking. Persistent smokers in this study seem to have an acceptable risk perception and were motivated to cease smoking, but needed assistance through cessation programs including prescription of pharmacological aids.

Trial registration

Registered at ClinicalTrials.gov: NCT02309255, registered retrospectively.
Literature
1.
2.
go back to reference Piepoli MF, Hoes AW, Agewall S, Albus C, Brotons C, Catapano AL, Cooney MT, Corra U, Cosyns B, Deaton C, et al. 2016 European Guidelines on cardiovascular disease prevention in clinical practice: The Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of 10 societies and by invited experts): Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR). Eur J Prev Cardiol. 2016;23(11):Np1–np96.CrossRefPubMed Piepoli MF, Hoes AW, Agewall S, Albus C, Brotons C, Catapano AL, Cooney MT, Corra U, Cosyns B, Deaton C, et al. 2016 European Guidelines on cardiovascular disease prevention in clinical practice: The Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of 10 societies and by invited experts): Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR). Eur J Prev Cardiol. 2016;23(11):Np1–np96.CrossRefPubMed
4.
go back to reference Critchley J, Capewell S. Smoking cessation for the secondary prevention of coronary heart disease. Cochrane Database Syst Rev. 2004;1:CD003041. Critchley J, Capewell S. Smoking cessation for the secondary prevention of coronary heart disease. Cochrane Database Syst Rev. 2004;1:CD003041.
5.
go back to reference Hartmann-Boyce J, Stead LF, Cahill K, Lancaster T. Efficacy of interventions to combat tobacco addiction: Cochrane update of 2013 reviews. Addiction. 2014;109(9):1414–25.CrossRefPubMed Hartmann-Boyce J, Stead LF, Cahill K, Lancaster T. Efficacy of interventions to combat tobacco addiction: Cochrane update of 2013 reviews. Addiction. 2014;109(9):1414–25.CrossRefPubMed
6.
go back to reference Cahill K, Stevens S, Perera R, Lancaster T. Pharmacological interventions for smoking cessation: an overview and network meta-analysis. Cochrane Database Syst Rev. 2013;5:CD009329. Cahill K, Stevens S, Perera R, Lancaster T. Pharmacological interventions for smoking cessation: an overview and network meta-analysis. Cochrane Database Syst Rev. 2013;5:CD009329.
7.
go back to reference Rigotti NA, Clair C, Munafo MR, Stead LF. Interventions for smoking cessation in hospitalised patients. Cochrane Database Syst Rev. 2012;5:CD001837.PubMedCentral Rigotti NA, Clair C, Munafo MR, Stead LF. Interventions for smoking cessation in hospitalised patients. Cochrane Database Syst Rev. 2012;5:CD001837.PubMedCentral
8.
go back to reference Kotseva K, Wood D, De Bacquer D, De Backer G, Ryden L, Jennings C, Gyberg V, Amouyel P, Bruthans J, Castro Conde A, et al. EUROASPIRE IV: A European Society of Cardiology survey on the lifestyle, risk factor and therapeutic management of coronary patients from 24 European countries. Eur J Prev Cardiol. 2016;23:636–48.CrossRefPubMed Kotseva K, Wood D, De Bacquer D, De Backer G, Ryden L, Jennings C, Gyberg V, Amouyel P, Bruthans J, Castro Conde A, et al. EUROASPIRE IV: A European Society of Cardiology survey on the lifestyle, risk factor and therapeutic management of coronary patients from 24 European countries. Eur J Prev Cardiol. 2016;23:636–48.CrossRefPubMed
10.
go back to reference Kotseva K, Wood D, De Backer G, De Bacquer D, Pyorala K, Keil U. Cardiovascular prevention guidelines in daily practice: a comparison of EUROASPIRE I, II, and III surveys in eight European countries. Lancet. 2009;373(9667):929–40.CrossRefPubMed Kotseva K, Wood D, De Backer G, De Bacquer D, Pyorala K, Keil U. Cardiovascular prevention guidelines in daily practice: a comparison of EUROASPIRE I, II, and III surveys in eight European countries. Lancet. 2009;373(9667):929–40.CrossRefPubMed
11.
go back to reference Young F, Capewell S, Ford ES, Critchley JA. Coronary mortality declines in the U.S. between 1980 and 2000 quantifying the contributions from primary and secondary prevention. Am J Prev Med. 2010;39(3):228–34.CrossRefPubMed Young F, Capewell S, Ford ES, Critchley JA. Coronary mortality declines in the U.S. between 1980 and 2000 quantifying the contributions from primary and secondary prevention. Am J Prev Med. 2010;39(3):228–34.CrossRefPubMed
12.
go back to reference Rigotti NA, Clair C. Managing tobacco use: the neglected cardiovascular disease risk factor. Eur Heart J. 2013;34(42):3259–67.CrossRefPubMed Rigotti NA, Clair C. Managing tobacco use: the neglected cardiovascular disease risk factor. Eur Heart J. 2013;34(42):3259–67.CrossRefPubMed
13.
go back to reference Pogosova N, Saner H, Pedersen SS, Cupples ME, McGee H, Hofer S, Doyle F, Schmid JP, von Kanel R. Psychosocial aspects in cardiac rehabilitation: From theory to practice. A position paper from the Cardiac Rehabilitation Section of the European Association of Cardiovascular Prevention and Rehabilitation of the European Society of Cardiology. Eur J Prev Cardiol. 2015;22(10):1290–306.CrossRefPubMed Pogosova N, Saner H, Pedersen SS, Cupples ME, McGee H, Hofer S, Doyle F, Schmid JP, von Kanel R. Psychosocial aspects in cardiac rehabilitation: From theory to practice. A position paper from the Cardiac Rehabilitation Section of the European Association of Cardiovascular Prevention and Rehabilitation of the European Society of Cardiology. Eur J Prev Cardiol. 2015;22(10):1290–306.CrossRefPubMed
15.
go back to reference Byrne M, Walsh J, Murphy AW. Secondary prevention of coronary heart disease: patient beliefs and health-related behaviour. J Psychosom Res. 2005;58(5):403–15.CrossRefPubMed Byrne M, Walsh J, Murphy AW. Secondary prevention of coronary heart disease: patient beliefs and health-related behaviour. J Psychosom Res. 2005;58(5):403–15.CrossRefPubMed
16.
go back to reference Chiriboga DE, Ockene JK, Ockene IS. Barriers to preventive interventions for coronary heart disease. Cardiol Clin. 2003;21(3):459–70.CrossRefPubMed Chiriboga DE, Ockene JK, Ockene IS. Barriers to preventive interventions for coronary heart disease. Cardiol Clin. 2003;21(3):459–70.CrossRefPubMed
17.
go back to reference Benowitz NL, Prochaska JJ. Smoking cessation after acute myocardial infarction. J Am Coll Cardiol. 2013;61(5):533–5.CrossRefPubMed Benowitz NL, Prochaska JJ. Smoking cessation after acute myocardial infarction. J Am Coll Cardiol. 2013;61(5):533–5.CrossRefPubMed
18.
go back to reference Munkhaugen J, Sverre E, Peersen K, Gjertsen E, Gullestad L, Moum T, Otterstad JE, Perk J, Husebye E, Dammen T. The role of medical and psychosocial factors for unfavourable coronary risk factor control. Scand Cardiovasc J. 2016;50(1):1–8.CrossRefPubMed Munkhaugen J, Sverre E, Peersen K, Gjertsen E, Gullestad L, Moum T, Otterstad JE, Perk J, Husebye E, Dammen T. The role of medical and psychosocial factors for unfavourable coronary risk factor control. Scand Cardiovasc J. 2016;50(1):1–8.CrossRefPubMed
19.
go back to reference Charlson ME, Pompei P, K L. A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation. J Chronic Dis. 1987;40:373–83.CrossRefPubMed Charlson ME, Pompei P, K L. A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation. J Chronic Dis. 1987;40:373–83.CrossRefPubMed
20.
go back to reference Bjelland I, Dahl AA, Haug TT, Neckelmann D. The validity of the Hospital Anxiety and Depression Scale. An updated literature review. J Psychosom Res. 2002;52(2):69–77.CrossRefPubMed Bjelland I, Dahl AA, Haug TT, Neckelmann D. The validity of the Hospital Anxiety and Depression Scale. An updated literature review. J Psychosom Res. 2002;52(2):69–77.CrossRefPubMed
21.
go back to reference Denollet J. DS14: standard assessment of negative affectivity, social inhibition, and Type D personality. Psychosom Med. 2005;67(1):89–97.CrossRefPubMed Denollet J. DS14: standard assessment of negative affectivity, social inhibition, and Type D personality. Psychosom Med. 2005;67(1):89–97.CrossRefPubMed
22.
go back to reference Pallesen S, Nordhus IH, Carlstedt B, Thayer JF, Johnsen TB. A Norwegian adaptation of the Penn State Worry Questionnaire: factor structure, reliability, validity and norms. Scand J Psychol. 2006;47(4):281–91.CrossRefPubMed Pallesen S, Nordhus IH, Carlstedt B, Thayer JF, Johnsen TB. A Norwegian adaptation of the Penn State Worry Questionnaire: factor structure, reliability, validity and norms. Scand J Psychol. 2006;47(4):281–91.CrossRefPubMed
23.
go back to reference Pallesen S, Bjorvatn B, Nordhus IH, Sivertsen B, Hjornevik M, Morin CM. A new scale for measuring insomnia: the Bergen Insomnia Scale. Percept Mot Skills. 2008;107(3):691–706.CrossRefPubMed Pallesen S, Bjorvatn B, Nordhus IH, Sivertsen B, Hjornevik M, Morin CM. A new scale for measuring insomnia: the Bergen Insomnia Scale. Percept Mot Skills. 2008;107(3):691–706.CrossRefPubMed
24.
go back to reference Broadbent E, Petrie KJ, Main J, Weinman J. The brief illness perception questionnaire. J Psychosom Res. 2006;60(6):631–7.CrossRefPubMed Broadbent E, Petrie KJ, Main J, Weinman J. The brief illness perception questionnaire. J Psychosom Res. 2006;60(6):631–7.CrossRefPubMed
25.
go back to reference Broadbent E, Petrie KJ, Ellis CJ, Anderson J, Gamble G, Anderson D, Benjamin W. Patients with acute myocardial infarction have an inaccurate understanding of their risk of a future cardiac event. Intern Med J. 2006;36(10):643–7.CrossRefPubMed Broadbent E, Petrie KJ, Ellis CJ, Anderson J, Gamble G, Anderson D, Benjamin W. Patients with acute myocardial infarction have an inaccurate understanding of their risk of a future cardiac event. Intern Med J. 2006;36(10):643–7.CrossRefPubMed
26.
go back to reference Gerber Y, Koren-Morag N, Myers V, Benyamini Y, Goldbourt U, Drory Y. Long-term predictors of smoking cessation in a cohort of myocardial infarction survivors: a longitudinal study. Eur J Cardiovasc Prev Rehabil. 2011;18(3):533–41.CrossRefPubMed Gerber Y, Koren-Morag N, Myers V, Benyamini Y, Goldbourt U, Drory Y. Long-term predictors of smoking cessation in a cohort of myocardial infarction survivors: a longitudinal study. Eur J Cardiovasc Prev Rehabil. 2011;18(3):533–41.CrossRefPubMed
27.
go back to reference Dullaghan L, Lusk L, McGeough M, Donnelly P, Herity N, Fitzsimons D. 'I am still a bit unsure how much of a heart attack it really was!' Patients presenting with non ST elevation myocardial infarction lack understanding about their illness and have less motivation for secondary prevention. Eur J Cardiovasc Nurs. 2014;13(3):270–6.CrossRefPubMed Dullaghan L, Lusk L, McGeough M, Donnelly P, Herity N, Fitzsimons D. 'I am still a bit unsure how much of a heart attack it really was!' Patients presenting with non ST elevation myocardial infarction lack understanding about their illness and have less motivation for secondary prevention. Eur J Cardiovasc Nurs. 2014;13(3):270–6.CrossRefPubMed
28.
go back to reference Prugger C, Wellmann J, Heidrich J, De Bacquer D, De Backer G, Perier MC, Empana JP, Reiner Z, Fras Z, Jennings C, et al. Readiness for smoking cessation in coronary heart disease patients across Europe: Results from the EUROASPIRE III survey. Eur J Prev Cardiol. 2015;22(9):1212–9.CrossRefPubMed Prugger C, Wellmann J, Heidrich J, De Bacquer D, De Backer G, Perier MC, Empana JP, Reiner Z, Fras Z, Jennings C, et al. Readiness for smoking cessation in coronary heart disease patients across Europe: Results from the EUROASPIRE III survey. Eur J Prev Cardiol. 2015;22(9):1212–9.CrossRefPubMed
29.
go back to reference Boggon R, Timmis A, Hemingway H, Raju S, Malvestiti FM, Van Staa TP. Smoking cessation interventions following acute coronary syndrome: a missed opportunity? Eur J Prev Cardiol. 2014;21(6):767–73.CrossRefPubMed Boggon R, Timmis A, Hemingway H, Raju S, Malvestiti FM, Van Staa TP. Smoking cessation interventions following acute coronary syndrome: a missed opportunity? Eur J Prev Cardiol. 2014;21(6):767–73.CrossRefPubMed
30.
go back to reference Perk J, Hambraeus K, Burell G, Carlsson R, Johansson P, Lisspers J. Study of Patient Information after percutaneous Coronary Intervention (SPICI): should prevention programmes become more effective? EuroIntervention. 2015;10(11):e1–7.CrossRefPubMed Perk J, Hambraeus K, Burell G, Carlsson R, Johansson P, Lisspers J. Study of Patient Information after percutaneous Coronary Intervention (SPICI): should prevention programmes become more effective? EuroIntervention. 2015;10(11):e1–7.CrossRefPubMed
31.
go back to reference Mathew AR, Hogarth L, Leventhal AM, Cook JW, Hitsman B. Cigarette smoking and depression comorbidity: systematic review and proposed theoretical model. Addiction. 2017;112(3):401–12.CrossRefPubMed Mathew AR, Hogarth L, Leventhal AM, Cook JW, Hitsman B. Cigarette smoking and depression comorbidity: systematic review and proposed theoretical model. Addiction. 2017;112(3):401–12.CrossRefPubMed
32.
go back to reference Doyle F, Rohde D, Rutkowska A, Morgan K, Cousins G, McGee H. Systematic review and meta-analysis of the impact of depression on subsequent smoking cessation in patients with coronary heart disease: 1990 to 2013. Psychosom Med. 2014;76(1):44–57.CrossRefPubMed Doyle F, Rohde D, Rutkowska A, Morgan K, Cousins G, McGee H. Systematic review and meta-analysis of the impact of depression on subsequent smoking cessation in patients with coronary heart disease: 1990 to 2013. Psychosom Med. 2014;76(1):44–57.CrossRefPubMed
33.
go back to reference Murphy BM, Grande MR, Navaratnam HS, Higgins RO, Elliott PC, Turner A, Rogerson MC, Worcester MU, Goble AJ. Are poor health behaviours in anxious and depressed cardiac patients explained by sociodemographic factors? Eur J Prev Cardiol. 2013;20(6):995–1003.CrossRefPubMed Murphy BM, Grande MR, Navaratnam HS, Higgins RO, Elliott PC, Turner A, Rogerson MC, Worcester MU, Goble AJ. Are poor health behaviours in anxious and depressed cardiac patients explained by sociodemographic factors? Eur J Prev Cardiol. 2013;20(6):995–1003.CrossRefPubMed
34.
go back to reference Svansdottir E, Karlsson HD, Gudnason T, Olason DT, Thorgilsson H, Sigtryggsdottir U, Sijbrands EJ, Pedersen SS, Denollet J. Validity of Type D personality in Iceland: association with disease severity and risk markers in cardiac patients. J Behav Med. 2012;35(2):155–66.CrossRefPubMed Svansdottir E, Karlsson HD, Gudnason T, Olason DT, Thorgilsson H, Sigtryggsdottir U, Sijbrands EJ, Pedersen SS, Denollet J. Validity of Type D personality in Iceland: association with disease severity and risk markers in cardiac patients. J Behav Med. 2012;35(2):155–66.CrossRefPubMed
35.
go back to reference Mommersteeg PM, Kupper N, Denollet J. Type D personality is associated with increased metabolic syndrome prevalence and an unhealthy lifestyle in a cross-sectional Dutch community sample. BMC Public Health. 2010;10:714.CrossRefPubMedPubMedCentral Mommersteeg PM, Kupper N, Denollet J. Type D personality is associated with increased metabolic syndrome prevalence and an unhealthy lifestyle in a cross-sectional Dutch community sample. BMC Public Health. 2010;10:714.CrossRefPubMedPubMedCentral
36.
go back to reference Murphy BM, Elliott PC, Higgins RO, Le Grande MR, Worcester MU, Goble AJ, Tatoulis J. Anxiety and depression after coronary artery bypass graft surgery: most get better, some get worse. Eur J Cardiovasc Prev Rehabil. 2008;15(4):434–40.CrossRefPubMed Murphy BM, Elliott PC, Higgins RO, Le Grande MR, Worcester MU, Goble AJ, Tatoulis J. Anxiety and depression after coronary artery bypass graft surgery: most get better, some get worse. Eur J Cardiovasc Prev Rehabil. 2008;15(4):434–40.CrossRefPubMed
37.
go back to reference Ceccarini M, Manzoni GM, Castelnuovo G. Assessing depression in cardiac patients: what measures should be considered? Depress Res Treat. 2014;2014:148256. doi:10.1155/2014/148256. Ceccarini M, Manzoni GM, Castelnuovo G. Assessing depression in cardiac patients: what measures should be considered? Depress Res Treat. 2014;2014:148256. doi:10.​1155/​2014/​148256.
38.
go back to reference West RR, Jones DA, Henderson AH. Rehabilitation after myocardial infarction trial (RAMIT): multi-centre randomised controlled trial of comprehensive cardiac rehabilitation in patients following acute myocardial infarction. Heart. 2012;98(8):637–44.CrossRefPubMed West RR, Jones DA, Henderson AH. Rehabilitation after myocardial infarction trial (RAMIT): multi-centre randomised controlled trial of comprehensive cardiac rehabilitation in patients following acute myocardial infarction. Heart. 2012;98(8):637–44.CrossRefPubMed
39.
go back to reference Giannuzzi P, Temporelli PL, Marchioli R, Maggioni AP, Balestroni G, Ceci V, Chieffo C, Gattone M, Griffo R, Schweiger C, et al. Global secondary prevention strategies to limit event recurrence after myocardial infarction: results of the GOSPEL study, a multicenter, randomized controlled trial from the Italian Cardiac Rehabilitation Network. Arch Intern Med. 2008;168(20):2194–204.CrossRefPubMed Giannuzzi P, Temporelli PL, Marchioli R, Maggioni AP, Balestroni G, Ceci V, Chieffo C, Gattone M, Griffo R, Schweiger C, et al. Global secondary prevention strategies to limit event recurrence after myocardial infarction: results of the GOSPEL study, a multicenter, randomized controlled trial from the Italian Cardiac Rehabilitation Network. Arch Intern Med. 2008;168(20):2194–204.CrossRefPubMed
40.
go back to reference Anderson L, Thompson DR, Oldridge N, Zwisler AD, Rees K, Martin N, Taylor RS. Exercise-based cardiac rehabilitation for coronary heart disease. Cochrane Database Syst Rev. 2016;1:CD001800. Anderson L, Thompson DR, Oldridge N, Zwisler AD, Rees K, Martin N, Taylor RS. Exercise-based cardiac rehabilitation for coronary heart disease. Cochrane Database Syst Rev. 2016;1:CD001800.
41.
go back to reference Taylor RS, Brown A, Ebrahim S, Jolliffe J, Noorani H, Rees K, Skidmore B, Stone JA, Thompson DR, Oldridge N. Exercise-based rehabilitation for patients with coronary heart disease: systematic review and meta-analysis of randomized controlled trials. Am J Med. 2004;116(10):682–92.CrossRefPubMed Taylor RS, Brown A, Ebrahim S, Jolliffe J, Noorani H, Rees K, Skidmore B, Stone JA, Thompson DR, Oldridge N. Exercise-based rehabilitation for patients with coronary heart disease: systematic review and meta-analysis of randomized controlled trials. Am J Med. 2004;116(10):682–92.CrossRefPubMed
42.
go back to reference Snaterse M, Scholte Op Reimer WJ, Dobber J, Minneboo M, Ter Riet G, Jorstad HT, Boekholdt SM, Peters RJ. Smoking cessation after an acute coronary syndrome: immediate quitters are successful quitters. Neth Heart J. 2015;23(12):600–7.CrossRefPubMedPubMedCentral Snaterse M, Scholte Op Reimer WJ, Dobber J, Minneboo M, Ter Riet G, Jorstad HT, Boekholdt SM, Peters RJ. Smoking cessation after an acute coronary syndrome: immediate quitters are successful quitters. Neth Heart J. 2015;23(12):600–7.CrossRefPubMedPubMedCentral
43.
go back to reference Lindson-Hawley N, Banting M, West R, Michie S, Shinkins B, Aveyard P. Gradual Versus Abrupt Smoking Cessation: A Randomized, Controlled Noninferiority Trial. Ann Intern Med. 2016;164(9):585–92.CrossRefPubMed Lindson-Hawley N, Banting M, West R, Michie S, Shinkins B, Aveyard P. Gradual Versus Abrupt Smoking Cessation: A Randomized, Controlled Noninferiority Trial. Ann Intern Med. 2016;164(9):585–92.CrossRefPubMed
44.
go back to reference Peersen K, Munkhaugen J, Gullestad L, Dammen T, Moum T, Otterstad JE. Reproducibility of an extensive self-report questionnaire used in secondary coronary prevention. Scand J Public Health. 2017;45:269–76.CrossRefPubMedPubMedCentral Peersen K, Munkhaugen J, Gullestad L, Dammen T, Moum T, Otterstad JE. Reproducibility of an extensive self-report questionnaire used in secondary coronary prevention. Scand J Public Health. 2017;45:269–76.CrossRefPubMedPubMedCentral
Metadata
Title
Medical and sociodemographic factors predict persistent smoking after coronary events
Authors
Elise Sverre
Jan Erik Otterstad
Erik Gjertsen
Lars Gullestad
Einar Husebye
Toril Dammen
Torbjørn Moum
John Munkhaugen
Publication date
01-12-2017
Publisher
BioMed Central
Published in
BMC Cardiovascular Disorders / Issue 1/2017
Electronic ISSN: 1471-2261
DOI
https://doi.org/10.1186/s12872-017-0676-1

Other articles of this Issue 1/2017

BMC Cardiovascular Disorders 1/2017 Go to the issue