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Published in: BMC Cardiovascular Disorders 1/2017

Open Access 01-12-2017 | Research article

Very early recurrence predicts long-term outcome in patients after atrial fibrillation catheter ablation: a prospective study

Authors: Yangjing Xue, Xiaoning Wang, Saroj Thapa, Luping Wang, Jiaoni Wang, Zhiqiang Xu, Shaoze Wu, Luyuan Tao, Guoqiang Wang, Lu Qian, Lianming Liao, Baohua Liu, Kangting Ji

Published in: BMC Cardiovascular Disorders | Issue 1/2017

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Abstract

Background

Long-term recurrence (LR) is a tendency that re-occurs within 3 months after catheter ablation for atrial fibrillation (AF). Whether very early recurrence (VER) within 7 days of post ablation is a prognostic factor of LR or not is unclear. For this reason, present study sought to examine the relationship between VER and LR.

Methods

In this prospective analysis 378 consecutive patients underwent an initial catheter ablation for paroxysmal or persistent AF. The association between VER and LR was analyzed by univariate and multivariate Cox regression, as well as time-dependent receiver operator characteristic (ROC) analysis.

Results

After a mean follow-up of 14.71 ± 8.58 months, 81 (65.90%) patients with VER experienced LR and were associated with lower event of free survival from LR (Log rank test, P < 0.001). Multivariate Cox regression analysis revealed that VER (HR = 7.02, 95% CI = 4.78–10.31; P < 0.001), left atrial enlargement (HR = 2.92, 95% CI = 1.88–4.54; P < 0.001), tendency in advanced age (HR = 1.50, 95% CI = 0.99–2.28; P = 0.054), and tendency in male (HR = 0.71, 95% CI = 0.50–1.01; P = 0.060) were independent predictors of LR. According to time-dependent ROC analysis, it was found that VER was more sensitive than common risk factors in predicting LR (0.74 vs 0.66, P < 0.001) and combination model further improved the C statistic for predicting LR (0.82 vs 0.66, P < 0.001).

Conclusions

After a single procedure of catheter ablation, patients with VER were strongly associated with LR and combination of VER and common risk factors could further improve prediction of patients who were at high risk for LR.
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Metadata
Title
Very early recurrence predicts long-term outcome in patients after atrial fibrillation catheter ablation: a prospective study
Authors
Yangjing Xue
Xiaoning Wang
Saroj Thapa
Luping Wang
Jiaoni Wang
Zhiqiang Xu
Shaoze Wu
Luyuan Tao
Guoqiang Wang
Lu Qian
Lianming Liao
Baohua Liu
Kangting Ji
Publication date
01-12-2017
Publisher
BioMed Central
Published in
BMC Cardiovascular Disorders / Issue 1/2017
Electronic ISSN: 1471-2261
DOI
https://doi.org/10.1186/s12872-017-0533-2

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