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Open Access 01-12-2015 | Research article

Platelet volume indices are associated with systolic and diastolic cardiac dysfunction, and left ventricular hypertrophy

Authors: Shu-ichi Fujita, Yoshihiro Takeda, Shun Kizawa, Takahide Ito, Kazushi Sakane, Toshiyuki Ikemoto, Yoshikatsu Okada, Koichi Sohmiya, Masaaki Hoshiga, Nobukazu Ishizaka

Published in: BMC Cardiovascular Disorders | Issue 1/2015

Abstract

Background

Mean platelet volume (MPV) and platelet distribution width (PDW) are indices that reflect platelet activity. We investigated the association between these platelet indices and left ventricular hypertrophy and cardiac function.

Methods

We analyzed the data of 1241 patients who were admitted to the Cardiology Department.

Results

Both MPV and PDW were selected as independent factors associated with left ventricular systolic and diastolic dysfunction, and left ventricular hypertrophy. The highest tertile of MPV and PDW was associated with left ventricular systolic dysfunction (left ventricular ejection fraction of <50 %) with an odds ratio of 1.53 and 2.03, respectively, when the respective lowest tertile was used as reference. The highest PDW tertile was associated with left ventricular hypertrophy with an odds ratio of 1.56 (95 % CI, 1.13–2.15) and with dysfunction with an odds ratio of 3.34 (95 % CI, 1.54–7.25).

Conclusions

Indices of platelet activation (MPV and/or PDW) were independently associated positively with left ventricular hypertrophy and left ventricular systolic and diastolic dysfunction. Whether these platelet indices represent useful markers for identifying individuals at higher risk for thromboembolic disease and organ damage among cardiac patients awaits further investigation.

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Title: Platelet volume indices are associated with systolic and diastolic cardiac dysfunction, and left ventricular hypertrophy
Authors: Shu-ichi Fujita
Yoshihiro Takeda
Shun Kizawa
Takahide Ito
Kazushi Sakane
Toshiyuki Ikemoto
Yoshikatsu Okada
Koichi Sohmiya
Masaaki Hoshiga
Nobukazu Ishizaka
Publication date: 01-12-2015
Publisher: BioMed Central
Published in: BMC Cardiovascular Disorders / Issue 1/2015
Electronic ISSN: 1471-2261
DOI: https://doi.org/10.1186/s12872-015-0047-8

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Platelet volume indices are associated with systolic and diastolic cardiac dysfunction, and left ventricular hypertrophy

Abstract

Background

Methods

Results

Conclusions

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