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BMC Immunology
Published in: BMC Immunology 1/2019

Open Access 01-12-2019 | Hepatitis | Research article

A comprehensive autoantigen-ome of autoimmune liver diseases identified from dermatan sulfate affinity enrichment of liver tissue proteins

Published in: BMC Immunology | Issue 1/2019

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Abstract

Background

Autoimmune diseases result from aberrant immune attacks by the body itself. It is mysterious how autoantigens, a large cohort of seemingly unconnected molecules expressed in different parts of the body, can induce similar autoimmune responses. We have previously found that dermatan sulfate (DS) can form complexes with molecules of apoptotic cells and stimulate autoreactive CD5+ B cells to produce autoantibodies. Hence, autoantigenic molecules share a unique biochemical property in their affinity to DS. This study sought to further test this uniform principle of autoantigenicity.

Results

Proteomes were extracted from freshly collected mouse livers. They were loaded onto columns packed with DS-Sepharose resins. Proteins were eluted with step gradients of increasing salt strength. Proteins that bound to DS with weak, moderate, or strong affinity were eluted with 0.4, 0.6, and 1.0 M NaCl, respectively. After desalting, trypsin digestion, and gel electrophoresis, proteins were sequenced by mass spectrometry. To validate whether these proteins have been previously identified as autoantigens, an extensive literature search was conducted using the protein name or its alternative names as keywords. Of the 41 proteins identified from the strong DS-affinity fraction, 33 (80%) were verified autoantigens. Of the 46 proteins with moderate DS-affinity, 27 (59%) were verified autoantigens. Of the 125 proteins with weak DS-affinity, 44 (35%) were known autoantigens. Strikingly, these autoantigens fell into the classical autoantibody categories of autoimmune liver diseases: ANA (anti-nuclear autoantibodies), SMA (anti-smooth muscle autoantibodies), AMA (anti-mitochondrial autoantibodies), and LKM (liver-kidney microsomal autoantigens).

Conclusions

This study of DS-affinity enrichment of liver proteins establishes a comprehensive autoantigen-ome for autoimmune liver diseases, yielding 104 verified and 108 potential autoantigens. The liver autoantigen-ome sheds light on the molecular origins of autoimmune liver diseases and further supports the notion of a unifying biochemical principle of autoantigenicity.
Literature
1.
Wang JY, Lee J, Yan M, Rho JH, Roehrl MH. Dermatan sulfate interacts with dead cells and regulates CD5(+) B-cell fate: implications for a key role in autoimmunity. Am J Pathol. 2011;178(5):2168–76.PubMedPubMedCentralCrossRef
2.
Rho JH, Zhang W, Murali M, Roehrl MH, Wang JY. Human proteins with affinity for dermatan sulfate have the propensity to become autoantigens. Am J Pathol. 2011;178(5):2177–90.PubMedPubMedCentralCrossRef
3.
Terziroli Beretta-Piccoli B, Mieli-Vergani G, Vergani D. Autoimmune hepatitis: standard treatment and systematic review of alternative treatments. World J Gastroenterol. 2017;23(33):6030–48.PubMedPubMedCentralCrossRef
4.
Trivedi HD, Lizaola B, Tapper EB, Bonder A. Primary biliary cholangitis: new treatments for an old disease. Frontline Gastroenterol. 2017;8(1):29–36.PubMedCrossRef
5.
6.
Sebode M, Weiler-Normann C, Liwinski T, Schramm C. Autoantibodies in autoimmune liver disease-clinical and diagnostic relevance. Front Immunol. 2018;9:609.PubMedPubMedCentralCrossRef
7.
8.
Dieker J, Berden JH, Bakker M, Briand JP, Muller S, Voll R, Sjowall C, Herrmann M, Hilbrands LB, van der Vlag J. Autoantibodies against modified histone peptides in SLE patients are associated with disease activity and lupus nephritis. PLoS One. 2016;11(10):e0165373.PubMedPubMedCentralCrossRef
9.
Burlingame RW, Rubin RL. Autoantibody to the nucleosome subunit (H2A-H2B)-DNA is an early and ubiquitous feature of lupus-like conditions. Mol Biol Rep. 1996;23(3–4):159–66.PubMedCrossRef
10.
Kwon YS, Chung J, Shin GT, Lee SY, Jang YJ. Variable region genes of human monoclonal autoantibodies to histones H2A and H2B from a systemic lupus erythematosus patient. Mol Immunol. 2005;42(3):311–7.PubMedCrossRef
11.
Wesierska-Gadek J, Penner E, Lindner H, Hitchman E, Sauermann G. Autoantibodies against different histone H1 subtypes in systemic lupus erythematosus sera. Arthritis Rheum. 1990;33(8):1273–8.PubMedCrossRef
12.
McClain MT, Ramsland PA, Kaufman KM, James JA. Anti-sm autoantibodies in systemic lupus target highly basic surface structures of complexed spliceosomal autoantigens. J Immunol. 2002;168(4):2054–62.PubMedCrossRef
13.
Wang H, Demirkan G, Bian X, Wallstrom G, Barker K, Karthikeyan K, Tang Y, Pasha SF, Leighton JA, Qiu J, et al. Identification of antibody against SNRPB, small nuclear Ribonucleoprotein-associated proteins B and B', as an autoantibody marker in Crohn's disease using an Immunoproteomics approach. J Crohns Colitis. 2017;11(7):848–56.PubMedCrossRef
14.
Mesa A, Somarelli JA, Wu W, Martinez L, Blom MB, Greidinger EL, Herrera RJ. Differential immunoglobulin class-mediated responses to components of the U1 small nuclear ribonucleoprotein particle in systemic lupus erythematosus and mixed connective tissue disease. Lupus. 2013;22(13):1371–81.PubMedCrossRef
15.
Reuter R, Rothe S, Habets W, Van Venrooij WJ, Luhrmann R. Autoantibody production against the U small nuclear ribonucleoprotein particle proteins E, F and G in patients with connective tissue diseases. Eur J Immunol. 1990;20(2):437–40.PubMedCrossRef
16.
Absi M, La Vergne JP, Marzouki A, Giraud F, Rigal D, Reboud AM, Reboud JP, Monier JC. Heterogeneity of ribosomal autoantibodies from human, murine and canine connective tissue diseases. Immunol Lett. 1989;23(1):35–41.PubMedCrossRef
17.
Neu E, von Mikecz AH, Hemmerich PH, Peter HH, Fricke M, Deicher H, Genth E, Krawinkel U. Autoantibodies against eukaryotic protein L7 in patients suffering from systemic lupus erythematosus and progressive systemic sclerosis: frequency and correlation with clinical, serological and genetic parameters. The SLE study group. Clin Exp Immunol. 1995;100(2):198–204.PubMedPubMedCentralCrossRef
18.
Perone D, Santos MA, Peixoto MS, Cicarelli RM. Trypanosoma cruzi: identification and characterization of a novel ribosomal protein L27 (TcrL27) that cross-reacts with an affinity-purified anti-Sm antibody. Parasitology. 2003;126(Pt 6):577–83.PubMed
19.
Becker A, Ludwig N, Keller A, Tackenberg B, Eienbroker C, Oertel WH, Fassbender K, Meese E, Ruprecht K. Myasthenia gravis: analysis of serum autoantibody reactivities to 1827 potential human autoantigens by protein macroarrays. PLoS One. 2013;8(3):e58095.PubMedPubMedCentralCrossRef
20.
Forne I, Carrascal M, Martinez-Lostao L, Abian J, Rodriguez-Sanchez JL, Juarez C. Identification of the autoantigen HB as the barrier-to-autointegration factor. J Biol Chem. 2003;278(50):50641–4.PubMedCrossRef
21.
Azizah MR, Azila MN, Zulkifli MN, Norita TY. The prevalence of antinuclear, anti-dsDNA, anti-Sm and anti-RNP antibodies in a group of healthy blood donors. Asian Pac J Allergy Immunol. 1996;14(2):125–8.PubMed
22.
Migliorini P, Baldini C, Rocchi V, Bombardieri S. Anti-Sm and anti-RNP antibodies. Autoimmunity. 2005;38(1):47–54.PubMedCrossRef
23.
Bledzhyants DA, Muratov RM, Movsesyan RR, Podlubnaya ZA. Autoantibodies to myosin light chains in the blood as early marker of myocardial injury after aortocoronary bypass surgery. Bull Exp Biol Med. 2007;144(2):241–5.PubMedCrossRef
24.
Latif N, Baker CS, Dunn MJ, Rose ML, Brady P, Yacoub MH. Frequency and specificity of antiheart antibodies in patients with dilated cardiomyopathy detected using SDS-PAGE and western blotting. J Am Coll Cardiol. 1993;22(5):1378–84.PubMedCrossRef
25.
Malka D, Pham BN, Courvalin JC, Corbic M, Pessayre D, Erlinger S. Acute hepatitis caused by alverine associated with anti-Lamin a and C autoantibodies. J Hepatol. 1997;27(2):399–403.PubMedCrossRef
26.
Kadam KM, Mande PV, Gawas N, Ahire S, Khole LV. Autoantibodies to heat-shock protein, HSPA5, and epitope spreading: high-dose dexamethasone therapy rescues ovarian function in experimental autoimmune ovarian insufficiency mouse model. Am J Reprod Immunol. 2016;75(5):580–93.PubMedCrossRef
27.
Toivola DM, Habtezion A, Misiorek JO, Zhang L, Nystrom JH, Sharpe O, Robinson WH, Kwan R, Omary MB. Absence of keratin 8 or 18 promotes antimitochondrial autoantibody formation in aging male mice. FASEB J. 2015;29(12):5081–9.PubMedPubMedCentralCrossRef
28.
Mayasari N, Van Knegsel AT, de Vries RG, Kemp B, Parmentier HK. Natural autoantibodies in Bos taurus calves during the first twelve weeks of life. Vet Immunol Immunopathol. 2016;178:70–8.PubMedCrossRef
29.
Okubo M, Yamamoto K, Kato T, Matsuura N, Nishimaki T, Kasukawa R, Ito K, Mizushima Y, Nishioka K. Detection and epitope analysis of autoantigen-reactive T cells to the U1-small nuclear ribonucleoprotein a protein in autoimmune disease patients. J Immunol. 1993;151(2):1108–15.PubMed
30.
Li L, Chen SH, Yu CH, Li YM, Wang SQ. Identification of hepatocellular-carcinoma-associated antigens and autoantibodies by serological proteome analysis combined with protein microarray. J Proteome Res. 2008;7(2):611–20.PubMedCrossRef
31.
Manns MP, Obermayer-Straub P. Cytochromes P450 and uridine triphosphate-glucuronosyltransferases: model autoantigens to study drug-induced, virus-induced, and autoimmune liver disease. Hepatology. 1997;26(4):1054–66.PubMedCrossRef
32.
Obermayer-Straub P, Manns MP. Cytochromes P450 and UDP-glucuronosyl-transferases as hepatocellular autoantigens. Baillieres Clin Gastroenterol. 1996;10(3):501–32.PubMedCrossRef
33.
Hao S, Fu R, Wang H, Shao Z. Screening novel autoantigens targeted by serum IgG autoantibodies in immunorelated pancytopenia by SEREX. Int J Hematol. 2017;106(5):622–30.PubMedCrossRef
34.
Edassery SL, Shatavi SV, Kunkel JP, Hauer C, Brucker C, Penumatsa K, Yu Y, Dias JA, Luborsky JL. Autoantigens in ovarian autoimmunity associated with unexplained infertility and premature ovarian failure. Fertil Steril. 2010;94(7):2636–41.PubMedPubMedCentralCrossRef
35.
Smith GC, Kenna JG, Harrison DJ, Tew D, Wolf CR. Autoantibodies to hepatic microsomal carboxylesterase in halothane hepatitis. Lancet. 1993;342(8877):963–4.PubMedCrossRef
36.
Miura H, Tobe T, Nakano Y. Analysis of epitope regions for autoantibodies in catalase. Immunol Investig. 2010;39(8):796–806.CrossRef
37.
D'Souza A, Kurien BT, Rodgers R, Shenoi J, Kurono S, Matsumoto H, Hensley K, Nath SK, Scofield RH. Detection of catalase as a major protein target of the lipid peroxidation product 4-HNE and the lack of its genetic association as a risk factor in SLE. BMC Med Genet. 2008;9:62.PubMedPubMedCentralCrossRef
38.
Kubota T, Iizuka H, Bachovchin WW, Stollar BD. Dipeptidyl peptidase IV (DP IV) activity in serum and on lymphocytes of MRL/Mp-lpr/lpr mice correlates with disease onset. Clin Exp Immunol. 1994;96(2):292–6.PubMedPubMedCentralCrossRef
39.
Vojdani A, Bazargan M, Vojdani E, Samadi J, Nourian AA, Eghbalieh N, Cooper EL. Heat shock protein and gliadin peptide promote development of peptidase antibodies in children with autism and patients with autoimmune disease. Clin Diagn Lab Immunol. 2004;11(3):515–24.PubMedPubMedCentral
40.
Shi L, Gehin T, Chevolot Y, Souteyrand E, Mange A, Solassol J, Laurenceau E. Anti-heat shock protein autoantibody profiling in breast cancer using customized protein microarray. Anal Bioanal Chem. 2016;408(5):1497–506.PubMedCrossRef
41.
Chen M, Shirai M, Czaja AJ, Kurokohchi K, Arichi T, Arima K, Kodama T, Nishioka M. Characterization of anti-histone antibodies in patients with type 1 autoimmune hepatitis. J Gastroenterol Hepatol. 1998;13(5):483–9.PubMedCrossRef
42.
Konikoff F, Swissa M, Shoenfeld Y. Autoantibodies to histones and their subfractions in chronic liver diseases. Clin Immunol Immunopathol. 1989;51(1):77–82.PubMedCrossRef
43.
Khan MA, Dixit K, Uddin M, Malik A, Alam K. Role of peroxynitrite-modified H2A histone in the induction and progression of rheumatoid arthritis. Scand J Rheumatol. 2012;41(6):426–33.PubMedCrossRef
44.
Xu Y, Liu AJ, Gao YX, Hu MG, Zhao GD, Zhao ZM, Liu R. Expression of Ku86 and presence of Ku86 antibody as biomarkers of hepatitis B virus related hepatocellular carcinoma. Dig Dis Sci. 2014;59(3):614–22.PubMedCrossRef
45.
Mahler M, Silverman ED, Schulte-Pelkum J, Fritzler MJ. Anti-Scl-70 (topo-I) antibodies in SLE: myth or reality? Autoimmun Rev. 2010;9(11):756–60.PubMedCrossRef
46.
Brahms H, Raymackers J, Union A, de Keyser F, Meheus L, Luhrmann R. The C-terminal RG dipeptide repeats of the spliceosomal Sm proteins D1 and D3 contain symmetrical dimethylarginines, which form a major B-cell epitope for anti-Sm autoantibodies. J Biol Chem. 2000;275(22):17122–9.PubMedCrossRef
47.
Lussiez V, Combe B, Graafland H, Rucheton M, Sany J. Anti-Sm and anti-RNP antibodies detected by immunoblotting in disseminated lupus erythematosus. Rev Rhum Mal Osteoartic. 1989;56(1):35–8.PubMed
48.
Mjelle JE, Rekvig OP, Fenton KA. Nucleosomes possess a high affinity for glomerular laminin and collagen IV and bind nephritogenic antibodies in murine lupus-like nephritis. Ann Rheum Dis. 2007;66(12):1661–8.PubMedPubMedCentralCrossRef
49.
Meyer O, Kuntz D, Kahn MF, Bourgeois R, Haim T. Characterization by immunoblotting (western blot) of anti-RNP antibodies in 36 connective tissue disease patients of whom 26 had mixed connective tissue disease. Comparison with 28 lupus patients with anti-Sm antibodies. Rev Rhum Mal Osteoartic. 1989;56(1):39–44.PubMed
50.
Fillit H, Shibata S, Sasaki T, Spiera H, Kerr LD, Blake M. Autoantibodies to the protein core of vascular basement membrane heparan sulfate proteoglycan in systemic lupus erythematosus. Autoimmunity. 1993;14(3):243–9.PubMedCrossRef
51.
Kaburaki J, Stollar BD. Identification of human anti-DNA, anti-RNP, anti-SM, and anti-SS-A serum antibodies bearing the cross-reactive 16/6 idiotype. J Immunol. 1987;139(2):385–92.PubMed
52.
Preuss B, Berg C, Altenberend F, Gregor M, Stevanovic S, Klein R. Demonstration of autoantibodies to recombinant human sulphite oxidase in patients with chronic liver disorders and analysis of their clinical relevance. Clin Exp Immunol. 2007;150(2):312–21.PubMedPubMedCentralCrossRef
53.
Zieve GW, Khusial PR. The anti-Sm immune response in autoimmunity and cell biology. Autoimmun Rev. 2003;2(5):235–40.PubMedCrossRef
54.
Jaekel HP, Klopsch T, Benkenstein B, Grobe N, Baldauf A, Schoessler W, Werle E. Reactivities to the Sm autoantigenic complex and the synthetic SmD1-aa83-119 peptide in systemic lupus erythematosus and other autoimmune diseases. J Autoimmun. 2001;17(4):347–54.PubMedCrossRef
55.
Kimura M, Tatsumi KI, Tada H, Ikemoto M, Fukuda Y, Kaneko A, Kato M, Hidaka Y, Amino N. Enzyme immunoassay for autoantibodies to human liver-type arginase and its clinical application. Clin Chem. 2000;46(1):112–7.PubMed
56.
Kit Y, Starykovych M, Vajrychova M, Lenco J, Zastavna D, Stoika R. Detection of novel auto-antigens in patients with recurrent miscarriage: description of an approach and preliminary findings. Croat Med J. 2014;55(3):259–64.PubMedPubMedCentralCrossRef
57.
Reuter R, Luhrmann R. Immunization of mice with purified U1 small nuclear ribonucleoprotein (RNP) induces a pattern of antibody specificities characteristic of the anti-Sm and anti-RNP autoimmune response of patients with lupus erythematosus, as measured by monoclonal antibodies. Proc Natl Acad Sci U S A. 1986;83(22):8689–93.PubMedPubMedCentralCrossRef
58.
Habets WJ, de Rooij DJ, Hoet MH, van de Putte LB, van Venrooij WJ. Quantitation of anti-RNP and anti-Sm antibodies in MCTD and SLE patients by immunoblotting. Clin Exp Immunol. 1985;59(2):457–66.PubMedPubMedCentral
59.
Reuter R, Appel B, Bringmann P, Rinke J, Luhrmann R. 5′-terminal caps of snRNAs are reactive with antibodies specific for 2,2,7-trimethylguanosine in whole cells and nuclear matrices. Double-label immunofluorescent studies with anti-m3G antibodies and with anti-RNP and anti-Sm autoantibodies. Exp Cell Res. 1984;154(2):548–60.PubMedCrossRef
60.
Marti A, Matsuda M, Sihag RK, Eliceiri GL. The small nuclear ribonucleoproteins that react with anti-Sm and anti-RNP antibodies. Biochem Biophys Res Commun. 1984;123(1):345–51.PubMedCrossRef
61.
Dinkel K, Rickert M, Moller G, Adamski J, Meinck HM, Richter W. Stiff-man syndrome: identification of 17 beta-hydroxysteroid dehydrogenase type 4 as a novel 80-kDa antineuronal antigen. J Neuroimmunol. 2002;130(1–2):184–93.PubMedCrossRef
62.
Kumagai T, Uchida M, Okumura N, Kameko M, Katsuyama T. Kanai M: [enzyme-linked immunosorbent assay for the detection of immunoglobulin class-specific anti-RNP and anti-Sm antibodies]. Rinsho Byori. 1988;36(6):699–704.PubMed
63.
Hwang HM, Heo CK, Lee HJ, Kwak SS, Lim WH, Yoo JS, Yu DY, Lim KJ, Kim JY, Cho EW. Identification of anti-SF3B1 autoantibody as a diagnostic marker in patients with hepatocellular carcinoma. J Transl Med. 2018;16(1):177.PubMedPubMedCentralCrossRef
64.
Okano Y, Targoff IN, Oddis CV, Fujii T, Kuwana M, Tsuzaka K, Hirakata M, Mimori T, Craft J, Medsger TA Jr. Anti-U5 small nuclear ribonucleoprotein (snRNP) antibodies: a rare anti-U snRNP specificity. Clin Immunol Immunopathol. 1996;81(1):41–7.PubMedCrossRef
65.
Mimori T, Hinterberger M, Pettersson I, Steitz JA. Autoantibodies to the U2 small nuclear ribonucleoprotein in a patient with scleroderma-polymyositis overlap syndrome. J Biol Chem. 1984;259(1):560–5.PubMed
66.
Lehmeier T, Foulaki K, Luhrmann R. Evidence for three distinct D proteins, which react differentially with anti-Sm autoantibodies, in the cores of the major snRNPs U1, U2, U4/U6 and U5. Nucleic Acids Res. 1990;18(22):6475–84.PubMedPubMedCentralCrossRef
67.
Mahesh SP, Li Z, Buggage R, Mor F, Cohen IR, Chew EY, Nussenblatt RB. Alpha tropomyosin as a self-antigen in patients with Behcet's disease. Clin Exp Immunol. 2005;140(2):368–75.PubMedPubMedCentralCrossRef
68.
Gajbhiye R, Sonawani A, Khan S, Suryawanshi A, Kadam S, Warty N, Raut V, Khole V. Identification and validation of novel serum markers for early diagnosis of endometriosis. Hum Reprod. 2012;27(2):408–17.PubMedCrossRef
69.
Kimura A, Sakurai T, Yamada M, Koumura A, Hayashi Y, Tanaka Y, Hozumi I, Ohtaki H, Chousa M, Takemura M, et al. Anti-endothelial cell antibodies in patients with cerebral small vessel disease. Curr Neurovasc Res. 2012;9(4):296–301.PubMedCrossRef
70.
Renaudineau Y, Dalekos GN, Gueguen P, Zachou K, Youinou P. Anti-alpha-actinin antibodies cross-react with anti-ssDNA antibodies in active autoimmune hepatitis. Clin Rev Allergy Immunol. 2008;34(3):321–5.PubMedCrossRef
71.
van Beers JJ, Willemze A, Stammen-Vogelzangs J, Drijfhout JW, Toes RE, Pruijn GJ. Anti-citrullinated fibronectin antibodies in rheumatoid arthritis are associated with human leukocyte antigen-DRB1 shared epitope alleles. Arthritis Res Ther. 2012;14(1):R35.PubMedPubMedCentralCrossRef
72.
Orth T, Gerken G, Kellner R, Meyer zum Buschenfelde KH, Mayet WJ. Actin is a target antigen of anti-neutrophil cytoplasmic antibodies (ANCA) in autoimmune hepatitis type-1. J Hepatol. 1997;26(1):37–47.PubMedCrossRef
73.
Caforio AL, Grazzini M, Mann JM, Keeling PJ, Bottazzo GF, McKenna WJ, Schiaffino S. Identification of alpha- and beta-cardiac myosin heavy chain isoforms as major autoantigens in dilated cardiomyopathy. Circulation. 1992;85(5):1734–42.PubMedCrossRef
74.
Senecal JL, Rauch J, Grodzicky T, Raynauld JP, Uthman I, Nava A, Guimond M, Raymond Y. Strong association of autoantibodies to human nuclear Lamin B1 with lupus anticoagulant antibodies in systemic lupus erythematosus. Arthritis Rheum. 1999;42(7):1347–53.PubMedCrossRef
75.
Garbarz M, Dhermy D, Bournier O, Bezeaud A, Boivin P. Anti-spectrin in sera containing smooth muscle autoantibodies from patients with chronic active hepatitis. Clin Exp Immunol. 1981;43(1):87–93.PubMedPubMedCentral
76.
Bansal D, Herbert F, Lim P, Deshpande P, Becavin C, Guiyedi V, de Maria I, Rousselle JC, Namane A, Jain R, et al. IgG autoantibody to brain beta tubulin III associated with cytokine cluster-II discriminate cerebral malaria in Central India. PLoS One. 2009;4(12):e8245.PubMedPubMedCentralCrossRef
77.
Le Naour F, Brichory F, Misek DE, Brechot C, Hanash SM, Beretta L. A distinct repertoire of autoantibodies in hepatocellular carcinoma identified by proteomic analysis. Mol Cell Proteomics. 2002;1(3):197–203.PubMedCrossRef
78.
Fregeau DR, Prindiville T, Coppel RL, Kaplan M, Dickson ER, Gershwin ME. Inhibition of alpha-ketoglutarate dehydrogenase activity by a distinct population of autoantibodies recognizing dihydrolipoamide succinyltransferase in primary biliary cirrhosis. Hepatology. 1990;11(6):975–81.PubMedCrossRef
79.
Carlsson L, Ronquist G, Nilsson BO, Larsson A. Dominant prostasome immunogens for sperm-agglutinating autoantibodies of infertile men. J Androl. 2004;25(5):699–705.PubMedCrossRef
80.
Dai L, Li J, Tsay JJ, Yie TA, Munger JS, Pass H, Rom WN, Tan EM, Zhang JY. Identification of autoantibodies to ECH1 and HNRNPA2B1 as potential biomarkers in the early detection of lung cancer. Oncoimmunology. 2017;6(5):e1310359.PubMedPubMedCentralCrossRef
81.
Pons C, Dansette PM, Gregeois J, Homberg JC, Billett EE, Mansuy D. Human anti-mitochondria autoantibodies appearing in iproniazid-induced immunoallergic hepatitis recognize human liver monoamine oxidase B. Biochem Biophys Res Commun. 1996;218(1):118–24.PubMedCrossRef
82.
Kemp EH, Ridgway JN, Smith KA, Watson PF, Weetman AP. Autoantibodies to the flavoprotein subunit of succinate dehydrogenase: analysis of specificity in autoimmune thyroid disease. Clin Endocrinol. 2000;53(3):291–9.CrossRef
83.
Loeper J, Descatoire V, Maurice M, Beaune P, Belghiti J, Houssin D, Ballet F, Feldmann G, Guengerich FP, Pessayre D. Cytochromes P-450 in human hepatocyte plasma membrane: recognition by several autoantibodies. Gastroenterology. 1993;104(1):203–16.PubMedCrossRef
84.
Cicek G, Vuorinen T, Stahle I, Stepanek P, Freudenberg N, Brandsch R. Coxsackievirus B3 infection induces anti-flavoprotein antibodies in mice. Clin Exp Immunol. 2000;122(3):404–9.PubMedPubMedCentralCrossRef
85.
Seko Y, Matsumoto A, Fukuda T, Imai Y, Fujimura T, Taka H, Mineki R, Murayama K, Hirata Y, Nagai R. A case of neonatal lupus erythematosus presenting delayed dilated cardiomyopathy with circulating autoantibody to annexin A6. Int Heart J. 2007;48(3):407–15.PubMedCrossRef
86.
Chakravarti R, Gupta K, Swain M, Willard B, Scholtz J, Svensson LG, Roselli EE, Pettersson G, Johnston DR, Soltesz EG, et al. 14-3-3 in thoracic aortic aneurysms: identification of a novel autoantigen in large vessel Vasculitis. Arthritis Rheumatol. 2015;67(7):1913–21.PubMedPubMedCentralCrossRef
87.
Kistner A, Bigler MB, Glatz K, Egli SB, Baldin FS, Marquardsen FA, Mehling M, Rentsch KM, Staub D, Aschwanden M, et al. Characteristics of autoantibodies targeting 14-3-3 proteins and their association with clinical features in newly diagnosed giant cell arteritis. Rheumatology (Oxford). 2017;56(5):829–34.PubMed
88.
Feist E, Kuckelkorn U, Dorner T, Donitz H, Scheffler S, Hiepe F, Kloetzel PM, Burmester GR. Autoantibodies in primary Sjogren's syndrome are directed against proteasomal subunits of the alpha and beta type. Arthritis Rheum. 1999;42(4):697–702.PubMedCrossRef
89.
Feist E, Dorner T, Kuckelkorn U, Schmidtke G, Micheel B, Hiepe F, Burmester GR, Kloetzel PM. Proteasome alpha-type subunit C9 is a primary target of autoantibodies in sera of patients with myositis and systemic lupus erythematosus. J Exp Med. 1996;184(4):1313–8.PubMedCrossRef
90.
Fierabracci A, Saura F. Identification of a common autoantigenic epitope of protein disulfide isomerase, golgin-160 and voltage-gated potassium channel in type 1 diabetes. Diabetes Res Clin Pract. 2010;88(2):e14–6.PubMedCrossRef
91.
Weber CK, Haslbeck M, Englbrecht M, Sehnert B, Mielenz D, Graef D, Distler JH, Mueller RB, Burkhardt H, Schett G, et al. Antibodies to the endoplasmic reticulum-resident chaperones calnexin, BiP and Grp94 in patients with rheumatoid arthritis and systemic lupus erythematosus. Rheumatology (Oxford). 2010;49(12):2255–63.CrossRef
92.
Miyachi K, Hosaka H, Nakamura N, Miyakawa H, Mimori T, Shibata M, Matsushima S, Chinoh H, Horigome T, Hankins RW, et al. Anti-p97/VCP antibodies: an autoantibody marker for a subset of primary biliary cirrhosis patients with milder disease? Scand J Immunol. 2006;63(5):376–82.PubMedCrossRef
93.
Kobayashi S, Hiwasa T, Arasawa T, Kagaya A, Ishii S, Shimada H, Ito M, Suzuki M, Kano M, Rahmutulla B, et al. Identification of specific and common diagnostic antibody markers for gastrointestinal cancers by SEREX screening using testis cDNA phage library. Oncotarget. 2018;9(26):18559–69.PubMedPubMedCentralCrossRef
94.
Liu M, Subramanian V, Christie C, Castro M, Mohanakumar T. Immune responses to self-antigens in asthma patients: clinical and immunopathological implications. Hum Immunol. 2012;73(5):511–6.PubMedPubMedCentralCrossRef
95.
Papiha SS, Pal B. Gc (vitamin D binding protein) subtypes in rheumatoid arthritis. Hum Genet. 1985;70(3):278–80.PubMedCrossRef
96.
Van den Bergh K, Vercammen M, Regenass S, Derua R, Vermeersch P, Pokreisz P, Ocmant A, de Beeck KO, Janssens S, Waelkens E, et al. Betaine homocysteine methyl transferase 1, a novel auto-antigen associated with anti-Golgi immune reactivity. Clin Chim Acta. 2012;413(1–2):105–8.PubMedCrossRef
97.
Vasilev VV, Noe R, Dragon-Durey MA, Chauvet S, Lazarov VJ, Deliyska BP, Fremeaux-Bacchi V, Dimitrov JD, Roumenina LT. Functional characterization of autoantibodies against complement component C3 in patients with lupus nephritis. J Biol Chem. 2015;290(42):25343–55.PubMedPubMedCentralCrossRef
98.
Arnett FC, Reichlin M. Lupus hepatitis: an under-recognized disease feature associated with autoantibodies to ribosomal P. Am J Med. 1995;99(5):465–72.PubMedCrossRef
99.
Yamagiwa S, Kamimura H, Takamura M, Aoyagi Y. Autoantibodies in primary biliary cirrhosis: recent progress in research on the pathogenetic and clinical significance. World J Gastroenterol. 2014;20(10):2606–12.PubMedPubMedCentralCrossRef
100.
Ehser J, Holdener M, Christen S, Bayer M, Pfeilschifter JM, Hintermann E, Bogdanos D, Christen U. Molecular mimicry rather than identity breaks T-cell tolerance in the CYP2D6 mouse model for human autoimmune hepatitis. J Autoimmun. 2013;42:39–49.PubMedCrossRef
Metadata
Title
A comprehensive autoantigen-ome of autoimmune liver diseases identified from dermatan sulfate affinity enrichment of liver tissue proteins
Publication date
01-12-2019
Published in
BMC Immunology / Issue 1/2019
Electronic ISSN: 1471-2172
DOI
https://doi.org/10.1186/s12865-019-0304-1

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