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Breast Cancer Research
Published in: Breast Cancer Research 3/2000

01-06-2000 | Review

Tyrosine kinase signalling in breast cancer: ErbB family receptor tyrosine kinases

Author: David F Stern

Published in: Breast Cancer Research | Issue 3/2000

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Abstract

ERBB family receptor tyrosine kinases are overexpressed in a significant subset of breast cancers. One of these receptors, HER2/neu, or ErbB-2, is the target for a new rational therapeutic antibody, Herceptin. Other inhibitors that target this receptor, and another family member, the epidermal growth factor (EGF) receptor, are moving into clinical trials. Both of these receptors are sometimes overexpressed in breast cancer, and still subject to regulation by hormones and other physiological regulators. Optimal use of therapeutics targeting these receptors will require consideration of the several modes of regulation of these receptors and their interactions with steroid receptors.
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Metadata
Title
Tyrosine kinase signalling in breast cancer: ErbB family receptor tyrosine kinases
Author
David F Stern
Publication date
01-06-2000
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 3/2000
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr51

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