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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 1/2012

Open Access 01-12-2012 | Poster presentation

Acute Serum Amyloid A induces cell migration cytoskeletal rearrangement and Notch signalling in rheumatoid arthritis

Authors: Mary Connolly, Peadar Rooney, Wei Gao, Douglas Veale, Ursula Fearon

Published in: Arthritis Research & Therapy | Special Issue 1/2012

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Excerpt

Acute Serum Amyloid A (A-SAA) is an acute phase protein strongly expressed in rheumatoid arthritis (RA) synovial tissue (ST) critically involved in regulating cell migration and angiogenesis. These processes are dependent on downstream interactions between extracellular matrix and cytoskeletal components. Additionally the Notch signalling pathway has been show to regulate endothelial cell (EC) morphogenesis and is critically involved in vessel formation, branching and morphogenesis. The aim of this study was to examine if A-SAA-induced angiogenesis, cell migration and invasion are mediated by the NOTCH signalling pathways. …
Metadata
Title
Acute Serum Amyloid A induces cell migration cytoskeletal rearrangement and Notch signalling in rheumatoid arthritis
Authors
Mary Connolly
Peadar Rooney
Wei Gao
Douglas Veale
Ursula Fearon
Publication date
01-12-2012
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue Special Issue 1/2012
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar3611

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