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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 1/2012

Open Access 01-12-2012 | Poster presentation

Decreased plating efficiency, proliferation and osteogenic differentiation of synovial fluid mesenchymal progenitors as a marker of severity of juvenile idiopathic arthritis

Authors: Elvira Lazic Mosler, Marija Jelusic-Drazic, Danka Grcevic, Ana Marusic, Natasa Kovacic

Published in: Arthritis Research & Therapy | Special Issue 1/2012

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Excerpt

Juvenile idiopathic arthritis (JIA) is a rheumatic pediatric disease characterized by synovial inflammation in one or more joints [1]. Inflammation results in hyperplastic changes of the synovium, destruction of articular cartilage and subchondral osteoresorption. Murine models of arthritis revealed impaired osteogenic/chondrogenic differentiation of synovial mesenchymal progenitors via inflammation-induced activation of NF-κB [2]. …
Literature
1.
Barr T, Carmichael NM, Sándor GK: Juvenile idiopathic arthritis: a chronic pediatric musculoskeletal condition with significant orofacial manifestations. J Can Dent Assoc. 2008, 74: 813-821.PubMed
2.
Li X, Makarov SS: An essential role of NF-kappaB in the "tumor-like" phenotype of arthritic synoviocytes. Proc Natl Acad Sci USA. 2006, 103: 17432-17437. 10.1073/pnas.0607939103.PubMedCentralCrossRefPubMed
Metadata
Title
Decreased plating efficiency, proliferation and osteogenic differentiation of synovial fluid mesenchymal progenitors as a marker of severity of juvenile idiopathic arthritis
Authors
Elvira Lazic Mosler
Marija Jelusic-Drazic
Danka Grcevic
Ana Marusic
Natasa Kovacic
Publication date
01-12-2012
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue Special Issue 1/2012
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar3636

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Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

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Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

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Developed by: Springer Medicine
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