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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 4/2011

01-08-2011 | Review

T-helper cells as new players in ANCA-associated vasculitides

Authors: Wayel H Abdulahad, Peter Lamprecht, Cees GM Kallenberg

Published in: Arthritis Research & Therapy | Issue 4/2011

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Abstract

In anti-neutrophil cytoplasmic autoantibody-associated vasculitides (AAV), several observations support a key role of T-helper cells (CD4+ T cells) in disease pathophysiology. An expanded population of effector memory CD4+ T cells in AAV patients may contribute to tissue injury and disease progression. In addition, functional impairment of regulatory T cells (TRegs) is reported in AAV patients. A fraction of TRegs have the capacity to differentiate into Th17 cells in the context of a proinflammatory environment. Therefore, nonfunctionality of TRegs described in AAV patients may be caused by their conversion into IL-17-producing cells that may contribute to granulomatous vasculitis. Further investigations directed at the plasticity of TRegs in AAV patients are warranted.
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Metadata
Title
T-helper cells as new players in ANCA-associated vasculitides
Authors
Wayel H Abdulahad
Peter Lamprecht
Cees GM Kallenberg
Publication date
01-08-2011
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 4/2011
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar3362

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