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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 4/2005

01-06-2005 | Review

The role of the complement and the FcγR system in the pathogenesis of arthritis

Authors: Samuel Solomon, Daniela Kassahn, Harald Illges

Published in: Arthritis Research & Therapy | Issue 4/2005

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Abstract

Autoantibodies in sera from patients with autoimmune diseases have long been known and have become diagnostic tools. Analysis of their functional role again became popular with the availability of mice mutant for several genes of the complement and Fcγ receptor (FcγR) systems. Evidence from different inflammatory models suggests that both systems are interconnected in a hierarchical way. The complement system mediators such as complement component 5a (C5a) might be crucial in the communication between the complement system and FcγR-expressing cells. The split complement protein C5a is known to inactivate cells by its G-protein-coupled receptor and to be involved in the transcriptional regulation of FcγRs, thereby contributing to the complex regulation of autoimmune disease.
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Metadata
Title
The role of the complement and the FcγR system in the pathogenesis of arthritis
Authors
Samuel Solomon
Daniela Kassahn
Harald Illges
Publication date
01-06-2005
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 4/2005
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar1761

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