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01-06-2005 | Commentary

Pathogenesis of rheumatoid arthritis: how early is early?

Author: Gary S Firestein

Published in: Arthritis Research & Therapy | Issue 4/2005

Abstract

Studies of cytokine expression in rheumatoid arthritis have provided key insights into the pathogenesis of disease and have offered clues for effective therapy. Patterns of T-cell products in chronic rheumatoid synovitis suggest that T helper type 1 cells contribute to the perpetuation of disease. However, there is no guarantee that the mechanisms of late disease are identical to very early rheumatoid arthritis. Evaluation of the cytokine profile at the earliest time points after onset of symptoms could identify novel targets that prevent progression to chronic arthritis.

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Title: Pathogenesis of rheumatoid arthritis: how early is early?
Author: Gary S Firestein
Publication date: 01-06-2005
Publisher: BioMed Central
Published in: Arthritis Research & Therapy / Issue 4/2005
Electronic ISSN: 1478-6362
DOI: https://doi.org/10.1186/ar1780

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