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Journal of the International AIDS Society
Published in: Journal of the International AIDS Society 4/2010

Open Access 01-12-2010 | Poster presentation

Therapeutics designed to neutralize soluble HIV tat protein could preserve IL-7 signaling and CD8 T-cell function in HIV+ patients

Authors: EM Faller, SM Sugden, PA MacPherson

Published in: Journal of the International AIDS Society | Special Issue 4/2010

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Excerpt

Interleukin (IL)-7 signaling is essential to CD8 T-cell development, homeostasis and function, and we have previously shown decreased expression of the IL-7 receptor alpha-chain (CD127) on CD8 T-cells in HIV+ patients. We have also shown that this down regulation of CD127 is mediated in part by soluble HIV Tat protein. By removing the IL-7 receptor from the cell surface, Tat is able to inhibit IL-7 signaling and impair both CD8 T-cell proliferation and cytolytic capacity. …
Metadata
Title
Therapeutics designed to neutralize soluble HIV tat protein could preserve IL-7 signaling and CD8 T-cell function in HIV+ patients
Authors
EM Faller
SM Sugden
PA MacPherson
Publication date
01-12-2010
Publisher
BioMed Central
DOI
https://doi.org/10.1186/1758-2652-13-S4-P227

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