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Journal of the International AIDS Society
Published in: Journal of the International AIDS Society 4/2010

Open Access 01-12-2010 | Poster presentation

Darunavir resistance spectrum in darunavir-na#239;ve patients harboring virological failure to antiretroviral therapy

Authors: AG Marcelin, C Charpentier, M Wirden, D Descamps, V Calvez

Published in: Journal of the International AIDS Society | Special Issue 4/2010

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Excerpt

Darunavir is one of the protease inhibitors that is recommended to treat protease inhibitor-naïve or -experienced patients. Recent studies have determined the spectrum of darunavir activity in patients failing to antiretroviral therapy. Darunavir resistance mutations in protease gene have been identified (V11I, V32I, L33F, I47V, I50V, I54L, I54M, T74P, L76V, I84V and L89V) and allow to classify viruses as sensitive (<3 mutations), possibly resistant (3 mutations) or resistant (≥4 mutations) to darunavir. …
Metadata
Title
Darunavir resistance spectrum in darunavir-na#239;ve patients harboring virological failure to antiretroviral therapy
Authors
AG Marcelin
C Charpentier
M Wirden
D Descamps
V Calvez
Publication date
01-12-2010
Publisher
BioMed Central
DOI
https://doi.org/10.1186/1758-2652-13-S4-P133

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