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Journal of the International AIDS Society
Published in: Journal of the International AIDS Society 4/2010

Open Access 01-12-2010 | Poster presentation

Toxic intracellular anabolite levels of tenofovir and didanosine causing a steep CD4-cell decline

Authors: E de Jong, ME Haverkort, R ter Heine, RS Jansen, JH Beijnen, MA van Agtmael

Published in: Journal of the International AIDS Society | Special Issue 4/2010

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Excerpt

HIV-protease inhibitors may increase tenofovir plasma AUC by 22-37%. Whether this affects tenofovir-diphosphate (TFV-DP) intracellular levels, especially in the presence of didanosine, which is also eliminated through active tubular secretion, is unclear. …
Literature
1.
Negredo E, Molto J, Burger D, Viciana P, Ribera E, Clotet B, et al: Unexpected CD4 cell count decline in patients receiving didanosine and tenofovir-based regimens despite undetectable viral load. AIDS. 2004, 18: 459-463. 10.1097/00002030-200402200-00012.CrossRefPubMed
2.
Pruvost A, Negredo E, Benech H, Theodoro F, Puig J, Grau E, et al: Measurement of intracellular didanosine and tenofovir phosphorylated metabolites and possible interaction of the two drugs in human immunodeficiency virus-infected patients. Antimicrob Agents Chemother. 2005, 49: 1907-1914. 10.1128/AAC.49.5.1907-1914.2005.PubMedCentralCrossRefPubMed
Metadata
Title
Toxic intracellular anabolite levels of tenofovir and didanosine causing a steep CD4-cell decline
Authors
E de Jong
ME Haverkort
R ter Heine
RS Jansen
JH Beijnen
MA van Agtmael
Publication date
01-12-2010
Publisher
BioMed Central
DOI
https://doi.org/10.1186/1758-2652-13-S4-P95

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