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Journal of Hematology & Oncology
Published in: Journal of Hematology & Oncology 1/2009

Open Access 01-12-2009 | Research

Skeletal Plasmacytoma: Progression of disease and impact of local treatment; an analysis of SEER database

Authors: Muhammad Umar Jawad, Sean P Scully

Published in: Journal of Hematology & Oncology | Issue 1/2009

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Abstract

Background

Previous reports suggest an as yet unidentifiable subset of patients with plasmacytoma will progress to myeloma. The current study sought to establish the risk of developing myeloma and determine the prognostic factors affecting the progression of disease.

Methods

Patients with plasmacytoma diagnosed between 1973 and 2005 were identified in the SEER database(1164 patients). Patient demographics and clinical characteristics, treatment(s), cause of death, and survival were extracted. Kaplan-Meier, log-rank, and Cox regression were used to analyze prognostic factors.

Results

The five year survival among patients initially diagnosed with plasmacytoma that later progressed to multiple myeloma and those initially diagnosed with multiple myeloma were almost identical (25% and 23%; respectively). Five year survival for patients with plasmacytoma that did not progress to multiple myeloma was significantly better (72%). Age > 60 years was the only factor that correlated with progression of disease (p = 0.027).

Discussion

Plasmacytoma consists of two cohorts of patients with different overall survival; those patients that do not progress to systemic disease and those that develop myeloma. Age > 60 years is associated with disease progression. Identifying patients with systemic disease early in the treatment will permit aggressive and novel treatment strategies to be implemented.
Appendix
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Metadata
Title
Skeletal Plasmacytoma: Progression of disease and impact of local treatment; an analysis of SEER database
Authors
Muhammad Umar Jawad
Sean P Scully
Publication date
01-12-2009
Publisher
BioMed Central
Published in
Journal of Hematology & Oncology / Issue 1/2009
Electronic ISSN: 1756-8722
DOI
https://doi.org/10.1186/1756-8722-2-41

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