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Fibrogenesis & Tissue Repair
Published in: Fibrogenesis & Tissue Repair 1/2011

Open Access 01-12-2011 | Review

Mesenchymal stem cells: from experiment to clinic

Authors: William R Otto, Nicholas A Wright

Published in: Fibrogenesis & Tissue Repair | Issue 1/2011

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Abstract

There is currently much interest in adult mesenchymal stem cells (MSCs) and their ability to differentiate into other cell types, and to partake in the anatomy and physiology of remote organs. It is now clear these cells may be purified from several organs in the body besides bone marrow. MSCs take part in wound healing by contributing to myofibroblast and possibly fibroblast populations, and may be involved in epithelial tissue regeneration in certain organs, although this remains more controversial. In this review, we examine the ability of MSCs to modulate liver, kidney, heart and intestinal repair, and we update their opposing qualities of being less immunogenic and therefore tolerated in a transplant situation, yet being able to contribute to xenograft models of human tumour formation in other contexts. However, such observations have not been replicated in the clinic. Recent studies showing the clinical safety of MSC in several pathologies are discussed. The possible opposing powers of MSC need careful understanding and control if their clinical potential is to be realised with long-term safety for patients.
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Metadata
Title
Mesenchymal stem cells: from experiment to clinic
Authors
William R Otto
Nicholas A Wright
Publication date
01-12-2011
Publisher
BioMed Central
Published in
Fibrogenesis & Tissue Repair / Issue 1/2011
Electronic ISSN: 1755-1536
DOI
https://doi.org/10.1186/1755-1536-4-20

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