Top

Published in:

Open Access 01-09-2013 | Poster presentation

Sirtuin mediated neuroprotection and its association with autophagy and apoptosis: Studies employing transgenic C. elegans model

Authors: Aamir Nazir, Pooja Jadiya

Published in: Molecular Neurodegeneration | Special Issue 1/2013

Excerpt

Sirtuins, NAD+-dependent protein deacetylases, are well known for their role in longevity. Aging is the major known risk factor for the onset of Parkinson’s disease (PD). In our previous studies, SIRT1 induction by calorie restriction (CR) diet regimen has been shown to protect against dopaminergic neurodegeneration via sir-2.1 mediated pathway. Taking the studies forward, we endeavoured to understand the role of nicotinamide adenine dinucleotide activated protein deacetylase Sir2p/Sirt1 in calorie restriction mediated prevention of Parkinsonism employing transgenic Caenorhabditis elegans expressing human alpha synuclein. …

Title: Sirtuin mediated neuroprotection and its association with autophagy and apoptosis: Studies employing transgenic C. elegans model
Authors: Aamir Nazir
Pooja Jadiya
Publication date: 01-09-2013
Publisher: BioMed Central
Published in: Molecular Neurodegeneration / Issue Special Issue 1/2013
Electronic ISSN: 1750-1326
DOI: https://doi.org/10.1186/1750-1326-8-S1-P65

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Sirtuin mediated neuroprotection and its association with autophagy and apoptosis: Studies employing transgenic C. elegans model

Excerpt

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Excerpt

Please log in to get access to this content

Other articles of this Special Issue 1/2013

A cell-based model of pathological tau uptake and propagation

Differential pathways for the interleukin-1β production activated by chromogranin A and Aβ in microglia

Monoamine oxidase B is associated with γ-secretase in cultured neurons and in brain

Identifying dominant modifiers of mutant FUS toxicity in vivo

Expanded G4C2 repeats linked to C9ORF72ALS and FTD form length-dependent RNA foci, sequester RNA binding proteins and are neurotoxic

Amyloid-β drives a type-1 interferon mediated neuro-inflammatory response in Alzheimer’s disease