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Molecular Neurodegeneration
Published in: Molecular Neurodegeneration 1/2013

Open Access 01-09-2013 | Poster presentation

Differential pathways for the interleukin-1β production activated by chromogranin A and Aβ in microglia

Authors: Zhou Wu, Hiroshi Nakanishi

Published in: Molecular Neurodegeneration | Special Issue 1/2013

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Excerpt

Although chromogranin A (CGA) is frequently present in Alzheimer’s disease (AD) senile plaques associated with microglial activation, little is known about basic difference between CGA and fibrillar Aβ as neuroinflammatory factors. Here we have thus compared the interleukin-1β (IL-1β) production pathways by CGA and fibrillar Aβ in microglia. …
Literature
1.
Terada K, Yamada J, Hayashi Y, Wu Z, Uchiyama Y, Peters C, Nakanishi H: Involvement of catepsin B in the processing and secretion of interleikin-1β in chromogranin A-stimulated microglia. Glia. 2010, 58: 114-124. 10.1002/glia.20906.CrossRefPubMed
2.
Sun L, Wu Z, Hayashi Y, Peters C, Tsuda T, Inoue K, Nakanishi H: Microglial cathepsin B contributes to the initiation of peripheral inflammation-induced chronic pain. J Neurosci. 2012, 32: 11330-11342. 10.1523/JNEUROSCI.0677-12.2012.CrossRefPubMed
Metadata
Title
Differential pathways for the interleukin-1β production activated by chromogranin A and Aβ in microglia
Authors
Zhou Wu
Hiroshi Nakanishi
Publication date
01-09-2013
Publisher
BioMed Central
Published in
Molecular Neurodegeneration / Issue Special Issue 1/2013
Electronic ISSN: 1750-1326
DOI
https://doi.org/10.1186/1750-1326-8-S1-P48

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