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Molecular Neurodegeneration
Published in: Molecular Neurodegeneration 1/2013

Open Access 01-09-2013 | Poster presentation

The beta-secretase-derived C-terminal fragment of APP (C99): a key determinant for intraneuronal pathology in the 3xTgAD mouse

Authors: Inger Lauritzen, Raphaelle Pardossi-Piquard, Charlotte Druon, Elizabeth Brigham, Daniel Abraham, Sébatien Ranaldi, Linda Chami, Julie Dunys, Fréderic Checler

Published in: Molecular Neurodegeneration | Special Issue 1/2013

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Excerpt

Triple-transgenic mice (3xTgAD) overexpressing Swedish-mutated b-amyloid-precursor-protein (APPswe), P310L-Tau (TauP301L) and physiological levels of M146V-presenilin-1 (PS1M146V) display extracellular amyloid-beta peptides (Abeta) deposits and Tau tangles at late ages. These mice also show an early, age-dependent and hippocampus specific accumulation of intra-neuronal APP-related materiel, which was firstly reported to correspond to Abeta. However, more recent work has disputed the presence of intra-neuronal Abeta and questioned its role in synaptic pathology and behavior. …
Metadata
Title
The beta-secretase-derived C-terminal fragment of APP (C99): a key determinant for intraneuronal pathology in the 3xTgAD mouse
Authors
Inger Lauritzen
Raphaelle Pardossi-Piquard
Charlotte Druon
Elizabeth Brigham
Daniel Abraham
Sébatien Ranaldi
Linda Chami
Julie Dunys
Fréderic Checler
Publication date
01-09-2013
Publisher
BioMed Central
Published in
Molecular Neurodegeneration / Issue Special Issue 1/2013
Electronic ISSN: 1750-1326
DOI
https://doi.org/10.1186/1750-1326-8-S1-P63

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