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Molecular Neurodegeneration
Published in: Molecular Neurodegeneration 1/2013

Open Access 01-09-2013 | Poster presentation

Late neurodegeneration in the Tau transgenic mouse model rTg4510

Authors: Lone Helboe, Christiane Volbracht

Published in: Molecular Neurodegeneration | Special Issue 1/2013

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Excerpt

The rTg4510 mouse overexpresses an inducible human mutant tau (TauP301L) selectively in the forebrain. This mouse exhibits Tau hyperphosphorylation at AD-relevant epitopes, accumulation of the 64 kDa tau species, and neurofibrillary tangles in cortex and hippocampus. …
Literature
1.
Ramsden M, Kotilinek L, Forster C, Paulson J, McGowan E, SantaCruz K, Guimaraes A, Yue M, Lewis J, Carlson G, Hutton M, Ashe KH: Age-dependent neurofibrillary tangle formation, neuron loss, and memory impairment in a mouse model of human tauopathy (P301L). Neurobiol Diesase. 2005, 25: 10637-10647.
Metadata
Title
Late neurodegeneration in the Tau transgenic mouse model rTg4510
Authors
Lone Helboe
Christiane Volbracht
Publication date
01-09-2013
Publisher
BioMed Central
Published in
Molecular Neurodegeneration / Issue Special Issue 1/2013
Electronic ISSN: 1750-1326
DOI
https://doi.org/10.1186/1750-1326-8-S1-P58

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