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Molecular Neurodegeneration
Published in: Molecular Neurodegeneration 1/2013

Open Access 01-09-2013 | Poster presentation

Tau-Hsp70 interaction on the single molecule level

Authors: Franziska Kundel, Magnus Kjaergaard, Sarah Shammas, Sophie Jackson, David Klenerman

Published in: Molecular Neurodegeneration | Special Issue 1/2013

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Excerpt

As the protein quality control centre of the cell molecular chaperones tightly regulate amyloid proteins and seem to alleviate their cytotoxicity. However, the precise mechanism of this interplay and how its modification leads to disease remain elusive. …
Literature
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Li H, Ying L, Green JJ, Balasubramanian S, Klenerman D: Ultrasensitive Coincidence Fluorescence Detection of Single DNA Molecules. Anal Chem. 2003, 75: 1664-1670. 10.1021/ac026367z.CrossRefPubMed
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Orte A, Birkett NR, Clarke RW, Devlin GL, Dobson CM, Klenerman D: Direct characterization of amyloidogenic oligomers by single-molecule fluorescence. Proc Natl Acad Sci. 2008, 105: 14424-14429. 10.1073/pnas.0803086105.PubMedCentralCrossRefPubMed
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Horrocks MH, Li H, Shim J-U, Ranasinghe RT, Clarke RW, Huck WTS, Abell C, Klenerman D: Single molecule fluorescence under conditions of fast flow. Anal Chem. 2012, 84: 179-185. 10.1021/ac202313d.CrossRefPubMed
Metadata
Title
Tau-Hsp70 interaction on the single molecule level
Authors
Franziska Kundel
Magnus Kjaergaard
Sarah Shammas
Sophie Jackson
David Klenerman
Publication date
01-09-2013
Publisher
BioMed Central
Published in
Molecular Neurodegeneration / Issue Special Issue 1/2013
Electronic ISSN: 1750-1326
DOI
https://doi.org/10.1186/1750-1326-8-S1-P61

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