Published in:
Open Access
01-09-2013 | Poster presentation
Glutathion-S-Transferases (GSTs) and Parkinson’s disease in a MPTP-induced C57BL/6 mouse model
Authors:
Elcin Deniz Ozdamar, Benay Can-Eke
Published in:
Molecular Neurodegeneration
|
Special Issue 1/2013
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Excerpt
Parkinson’s disease (PD) is the second most common neurodegenerative disorder after Alzheimer disease and affects up to 2% of individuals after the age 65. It is characterized by progressive motor decline and loss of dopaminergic neurons from the substantia nigra (SN) leading resting tremor, rigidity, bradykinesia and postural instability. Differential characteristics of PD pathology is the loss of dopaminergic neurons and the presence of intracellular protein aggregates. The etiology of the disease is still unknown and it is likely due to a multifactorial interaction of genes and the environmental factors on the background of ageing. …