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Molecular Neurodegeneration
Published in: Molecular Neurodegeneration 1/2013

Open Access 01-09-2013 | Poster presentation

Aneuploidy-driven non-heritable genomic variations demonstrate area-specific distribution in the Alzheimer’s disease brain

Authors: Ivan lourov, Svetlana Vorsanova, Thomas Liehr, Yuri Yurov

Published in: Molecular Neurodegeneration | Special Issue 1/2013

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Excerpt

Post-zygotic aneuploidy is the prominent genetic feature of the human brain (1). Genomically mosaic brain results from that the excess of aneuploid neurons due to early developmental disturbances (somatic genome variations), abnormal cell cycle regulation and altered programmed cell death. As the result, aneuploidization of the brain is a likely susceptibility factor (mechanism) for brain disorders including Alzheimer’s disease. …
Literature
1.
lourov lY, Vorsanova SG, Yurov YB: Somatic genome variations in health and disease. Current Genomics. 2010, 11: 387-396. 10.2174/138920210793176065.CrossRef
2.
lourov lY, Vorsanova SG, Liehr T, Yurov YB: Aneuploidy in the normal, Alzheimer’s disease and ataxia-telangiectasia brain: differential expression and pathological meaning. Neurobiol Dis. 2009, 34: 212-220. 10.1016/j.nbd.2009.01.003.CrossRef
3.
Yurov YB, Vorsanova SG, lourov lY: GIN’n’CIN hypothesis of brain aging: deciphering the role of somatic genetic instabilities and neural aneuploidy during ontogeny. Molecular Cytogenetics. 2009, 2: 23-10.1186/1755-8166-2-23.PubMedCentralCrossRefPubMed
Metadata
Title
Aneuploidy-driven non-heritable genomic variations demonstrate area-specific distribution in the Alzheimer’s disease brain
Authors
Ivan lourov
Svetlana Vorsanova
Thomas Liehr
Yuri Yurov
Publication date
01-09-2013
Publisher
BioMed Central
Published in
Molecular Neurodegeneration / Issue Special Issue 1/2013
Electronic ISSN: 1750-1326
DOI
https://doi.org/10.1186/1750-1326-8-S1-P52

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