Published in:
Open Access
01-09-2013 | Poster presentation
Regulation of key proteins in Alzheimer’s disease molecular pathogenesis by ubiquilin-1
Authors:
Mari Takalo, Jayashree Viswanathan, Teemu Natunen, Kaisa MA Kurkinen, Heikki Tanila, Hilkka Soininen, Rudolph E Tanzi, Mikko Hiltunen, Annakaisa Haapasalo
Published in:
Molecular Neurodegeneration
|
Special Issue 1/2013
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Excerpt
Ubiquilin-1 is a ubiquitin-like protein involved in the pathogenesis of Alzheimer’s disease (AD) and other neurodegenerative disorders via different mechanisms. UBQLN1 UBQ-8i genetic variation associates with increased AD risk. Ubiquilin-1 protein functions as a molecular chaperone controlling amyloid precursor protein (APP) trafficking and processing and presenilin (PS) levels and subcellular targeting. Ubiquilin-1 harbors a ubiquitin-like (UBL) domain interacting with the proteasome and a ubiquitin-associated (UBA) domain binding polyubiquitinated proteins. Thus, it may target polyubiquitinated proteins to degradation. Alternative splicing of UBQLN1 generates four transcript variants (TV) with varying domain structures, suggesting that diverse variants may specifically interact with and regulate different proteins and cellular functions. …