Published in:
Open Access
01-09-2013 | Poster presentation
Generation and characterization of individual-specific induced pluripotent cells from patient-derived lymphoblastoid cell lines
Authors:
Shadaan Zulfiqar, Radhika Menon, Tara Atmaram, Meera Purushottam, Matthew Varghese, Sanjeev Jain, Mitradas Panicker, Odity Mukherjee
Published in:
Molecular Neurodegeneration
|
Special Issue 1/2013
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Excerpt
Alzheimer’s disease (AD) is a common neurodegenerative disorder that leads to cognitive impairment. In India, the prevalence of AD is currently ~3.5 million but due to its large population and the recent increase in longevity, is projected to increase to 7-9 million by 2020. Thus, AD is a significant burden of disease in our country. Genetic variations play a major role in AD. The apolipoprotein-E gene and in particular its ε4 allele account for 20-50% of the total genetic variance in disease risk. One copy of ε4 allele increases risk for AD by ~threefold, and two copies, by more than ten-fold. But still, ε4 allele is neither necessary nor sufficient for the development of the disease, indicating involvement of other genetic risk factors, alone or in conjunction with the ε4 allele underlying disease predisposition. …
