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Nutrition & Metabolism
Published in: Nutrition & Metabolism 1/2010

Open Access 01-12-2010 | Review

Cancer as a metabolic disease

Authors: Thomas N Seyfried, Laura M Shelton

Published in: Nutrition & Metabolism | Issue 1/2010

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Abstract

Emerging evidence indicates that impaired cellular energy metabolism is the defining characteristic of nearly all cancers regardless of cellular or tissue origin. In contrast to normal cells, which derive most of their usable energy from oxidative phosphorylation, most cancer cells become heavily dependent on substrate level phosphorylation to meet energy demands. Evidence is reviewed supporting a general hypothesis that genomic instability and essentially all hallmarks of cancer, including aerobic glycolysis (Warburg effect), can be linked to impaired mitochondrial function and energy metabolism. A view of cancer as primarily a metabolic disease will impact approaches to cancer management and prevention.
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Metadata
Title
Cancer as a metabolic disease
Authors
Thomas N Seyfried
Laura M Shelton
Publication date
01-12-2010
Publisher
BioMed Central
Published in
Nutrition & Metabolism / Issue 1/2010
Electronic ISSN: 1743-7075
DOI
https://doi.org/10.1186/1743-7075-7-7

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