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Virology Journal

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Open Access 01-12-2010 | Research

Prevalence and risk factors of hepatitis B and C viruses among haemodialysis patients in Gaza strip, Palestine

Authors: Abed El-kader Y El-Ottol, Abdelraouf A Elmanama, Basim M Ayesh

Published in: Virology Journal | Issue 1/2010

Abstract

Background

The prevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) and its associated risk factors among haemodialysis (HD) patients in Gaza strip was investigated using serological and molecular techniques.

Results

The overall prevalence of HBV among the four HD centers was 8.1%. The main risk factors were HD center (p = 0.05), history of blood transfusion (p < 0.01), and treatment abroad (p = 0.01). The overall prevalence of HCV among the four HD centers was 22%. The main risk factors were HD center (p < 0.01), time duration on HD (p < 0.01), history of blood transfusion (p < 0.01), treatment abroad (p < 0.01), and history of blood transfusion abroad (p < 0.01). Serum aminotransferases levels decreased in HD patients compared with normal population but still there was a direct association between the activity of liver enzymes and both HBV (p < 0.01) and HCV (p < 0.01) infection.

Conclusion

The much higher prevalence of Hepatitis viruses among HD patients compared to the normal population of Gaza strip indicates a causative relation between HD and hepatitis viruses transmission. Therefore extremely careful observation of preventive infection control measures is essential to limit Hepatitis viruses' transmission in HD centers.

Saha D, Agarwal SK: Hepatitis and HIV infection during haemodialysis. J Indian Med Assoc 2001,99(4):194-199. 203,213PubMed

Boulaajaj K, Elomari Y, Elmaliki B, Madkouri B, Zaid D, Benchemsi N: Prevalence of hepatitis C, hepatitis B and HIV infection among haemodialysis patients in Ibn-Rochd university hospital, Casablanca. Nephrol Ther 2005,1(5):274-284.PubMedCrossRef

Al Hijazat M, Ajlouni Y: Hepatitis B infection among patients receiving chronic hemodialysis at the royal medical services in Jordan. Saudi J Kidney Dis Transpl 2008,19(2):260-267.PubMed

Khan LA, Khan SA: Prevalence of hepatitis B and C markers in patients on maintenance hemodialysis in Najran. Saudi Med J 2001,22(7):641-642.PubMed

Almawi WY, Qadi AA, Tamim H, Ameen G, Bu-Ali A, Arrayid S, Abou Jaoude MM: Seroprevalence of hepatitis C virus and hepatitis B virus among dialysis patients in Bahrain and Saudi Arabia. Transplant Proc 2004,36(6):1824-1826. 10.1016/j.transproceed.2004.07.019PubMedCrossRef

Naman RE, Mansour I, Klayme S, Khalil G: Hepatitis C virus in hemodialysis patients and blood donors in Lebanon. J Med Liban 1996,44(1):4-9.PubMed

Bdour S: Hepatitis C virus infection in Jordanian haemodialysis units: serological diagnosis and genotyping. J Med Microbiol 2002,51(8):700-704.PubMedCrossRef

Hachicha J, Hammami A, Masmoudi H, Ben Hmida M, Karray H, Kharrat M, Kammoun F, Jarraya A: Viral hepatitis C in chronic hemodialysis patients in southern Tunisia, prevalence and risk factor. Ann Med Interne 1995,146(5):295-298.

Abdulkarim AS, Zein NN, Germer JJ, Kolbert CP, Kabbani L, Krajnik KL, Hola A, Agha MN, Tourogman M, Persing DH: Hepatitis C virus genotype and hepatitis G virus in hemodialysis patients from Syria: identification of two novel hepatitis C virus subtypes. Am J Trop Med Hyg 1998,59(4):571-576.PubMed

10.

Goldbloom SE, Reed WP: Host defenses and immunologic alterations associated with chronic hemodialysis. Ann Intern Med 1980,93(4):597-613.CrossRef

11.

Fabrizi F, Martin P, Dixit V, Brezina M, Russell J, Conrad A, Schmid P, Gerosa S, Gitnick G: Detection of de novo hepatitis C virus infection by polymerase chain reaction in hemodialysis patients. Am J Nephrol 1999,19(3):383-388. 10.1159/000013482PubMedCrossRef

12.

Ministry Of Health: Palestinian clinical laboratory tests guide. MOH 2005.

13.

Stuyver L, Rossau R, Wyseur A, Duhamel M, Vanderborght B, Van Heuverswyn H, Maertens G: Typing of hepatitis C virus isolates and characterization of new subtypes using a line probe assay. J Gen Virol 1993,74(pt 6):1093-1102. 10.1099/0022-1317-74-6-1093PubMedCrossRef

14.

Feher T, Ambuhi PM: Chronic hepatitis virus infections in patients on renal replacement therapy. Nephrol Dial Transplant 2004,19(5):1049-1053. 10.1093/ndt/gfh080CrossRef

15.

Covic A, Iancu L, Apetrei C, Scripcaru D, Volovat C, Mititiuc I, Covic M: Hepatits virus infection in haemodialysis patients from Moldavia. Nephrol Dial Transplant 1999,14(1):40-45. 10.1093/ndt/14.1.40PubMedCrossRef

16.

Busek SU, Babá EH, Tavares Filho HA, Pimenta L, Salomão A, Corrêa-Oliveira R, Oliveira GC: Hepatitis C and Hepatitis B Virus Infection in Different Hemodialysis Units in Belo Horizonte, Minas Gerais, Brazil. Mem Inst Oswaldo Cruz 2002,97(6):775-778. 10.1590/S0074-02762002000600003PubMedCrossRef

17.

Jauréguiberry S, Grandière-Pérez L, Ansart S, Laklache H, Métivier S, Caumes E: Acute hepatitis C virus infection after a travel in India. J Travel Med 2005,12(1):55-56.PubMedCrossRef

18.

Busek S, Oliveira G: Molecular epidemiology of the hepatitis C virus in Brazil. Genet Mol Res 2003,2(1):117-123.PubMed

19.

Yassin K, Awad R, Tebi AJ, Queder A, Laaser U: Prevalence and risk factors of HBsAg in Gaza: Implications for prevention and control. J Infect 2002,44(4):252-256. 10.1053/jinf.2001.0998PubMedCrossRef

20.

Kalaajieh W, Deeaoui M, Chbani-Rima A: Epidemiology of acute hepatitis B infection in Lebnon. Med Mal Infect 2002,32(7):382-386. 10.1016/S0399-077X(02)00385-2CrossRef

21.

Ayed K, Gorgi Y, Ben Abdallah T, Aouadi H, Jendoubi-Ayed S, Sfar I, Makni H: Hepatitis C virus infection in hemodialysis patients from Tunisia: national survey by serologic and molecular methods. Transplant Proc 2003,35(7):2573-2575. 10.1016/j.transproceed.2003.09.005PubMedCrossRef

22.

Carneiro MA, Martins RM, Teles SA, Silva SA, Lopes CL, Cardoso DD, Vanderborght BO, Yoshida CF: Hepatitis C prevalence and risk factors in hemodialysis patients in central Brazil: a survey by polymerase chain reaction and serological methods. Mem Inst Oswaldo Cruz 2001,96(6):765-769. 10.1590/S0074-02762001000600003PubMedCrossRef

23.

Rigopoulou EI, Stefanidis I, Liaskos C, Zervou EK, Rizos C, Mina P, Zachou K, Syrganis C, Patsidis E, Kyriakopoulos G, Sdrakas L, Tsianas N, Dalekos GN: HCV RNA qualitative assay based on transcription mediated amplification improves the detection of hepatitis C virus infection in patients on hemodialysis: Results from five hemodialysis units in central Greece. J Clin Virol 2005,34(1):81-85. 10.1016/j.jcv.2005.05.007PubMedCrossRef

24.

Furusyo N, Hayashi J, Ariyama I, Sawayama Y, Etoh Y, Shigematsu M, Kashiwagi S: Maintenance hemodialysis decreases serum hepatitis C virus (HCV) RNA levels in hemodialysis patients with chronic HCV infection. Am J Gastroenterol 2000,95(2):490-496. 10.1111/j.1572-0241.2000.01773.xPubMedCrossRef

25.

Bukh J, Wantzin P, Krogsgaard K, Knudsen F, Purcell RH, Miller RH: High prevalence of hepatitis C virus (HCV) RNA in dialysis patients: failure of commercially available antibody tests to identify a signiticant number of patients with HCV infection. J Infect Dis 1993,168(6):1343-1348.PubMedCrossRef

26.

Albuquerque AC, Coêlho MR, Lopes EP, Lemos MF, Moreira RC: Prevalence and risk factors of hepatitis C virus infection in hemodialysis patients from one center in Recife, Brazi. Mem Inst Oswaldo Cruz-Rio de Janeiro 2005,100(5):467-470.CrossRef

27.

28.

Hinrichsen H, Leimenstoll G, Stegen G, Schrader H, Fölsch UR, Schmidt WE, PHV Study Group: Prevalence and risk factors of hepatitis C virus infection in haemodialysis patients: a multicentre study in 2796 patients. Gut 2002,51(3):429-433. 10.1136/gut.51.3.429PubMedPubMedCentralCrossRef

29.

Reddy GA, Dakshinamurthy KV, Neelaprasad P, Gangadhar T, Lakshmi V: Prevelance of HBV and HCV dual infection in patients on hemodialysis. Indian J Med Microbiol 2005,23(1):41-43. 10.4103/0255-0857.13872PubMedCrossRef

30.

Irish DN, Blake C, Christophers J, Craske JE, Burnapp L, Abbs IC, MacMahon EM, Muir P, Banatvala JE, Simmonds P: Identification of hepatitis C seroconversion resulting from nosocomial transmission on a haemodiolysis unit: implications for infection control and laboratory screening. J Med Virol 1999,59(2):135-140. 10.1002/(SICI)1096-9071(199910)59:2<135::AID-JMV2>3.0.CO;2-YPubMedCrossRef

31.

Allander T, Gruber A, Naghavi M, Beyene A, Söderström T, Björkholm M, Grillner L, Persson MA: Frequent patient to patient transmission of hepatitis C virus in a haematology ward. Lancet 1995,345(8950):603-607. 10.1016/S0140-6736(95)90518-9PubMedCrossRef

32.

Sartor C, Brunet P, Simon S, Tamalet C, Berland Y, Drancourt M: Transmission of hepatitis C virus between hemodialysis patients sharing the same machine. Infect Control Hosp Epidemiol 2004,25(7):609-611. 10.1086/502448PubMedCrossRef

33.

de Medina M, Ashby M, Schlüter V, Hill M, Leclerq B, Pennell JP, Jeffers LJ, Reddy KR, Schiff ER, Hess G, Perez GO: Prevalence of hepatitis C and G virus infection in chronic hemidialysis patients. Am J Kidney Dis 1998,31(2):224-226. 10.1053/ajkd.1998.v31.pm9469491PubMedCrossRef

34.

Lopes EP, Gouveia EC, Albuquerque AC, Sette LH, Mello LA, Moreira RC, Coelho MR: Determination of the cut off value of serum alanine aminotransferase in patients undergoing hemodialysis, to identify biochemical activity in patients with hepatitis C viraemia. J clin Virol 2006,35(3):298-302. 10.1016/j.jcv.2005.09.010PubMedCrossRef

35.

el-Sadawy M, Ragab H, el-Toukhy H, el-Mor Ael-L, Mangoud AM, Eissa MH, Afefy AF, el-Shorbagy E, Ibrahem IA, Mahrous S, Abdel-Monem A, Sabee EI, Ismail A, Morsy TA, Etewa S, Nor Edin E, Mostafa Y, Abouel-Magd Y, Hassan MI, Lakouz K, Abdel-Aziz K, el-Hady G, Saber M: Hepatitis C virus infection at Sharkia Governorate, Egypt: seroprevalence and associated risk factors. J Egypt Soc Parasitol 2004,34(1 Suppl):367-384.PubMed

36.

Dussol B, Berthezène P, Brunet P, Roubicek C, Berland Y: Hepatits C virus among chronic dialysis patients in the south of France: a collaborative study. Am J Kidney Dis 1995,25(3):399-404. 10.1016/0272-6386(95)90100-0PubMedCrossRef

37.

Fabrizi F, Lunghi G, Finazzi S, Colucci P, Pagano A, Ponticelli C, Locatelli F: Decreased serum aminotransferase activity in patients with chronic renal failure: impact on the detection of viral hepatitis. Am J Kidney Dis 2001,38(5):1009-1015. 10.1053/ajkd.2001.28590PubMedCrossRef

38.

Gouveia EC, Lopes EP, Moura I, Cruz M, Kosminsky L, Pernambuco JR: Identification of the cut-off value for serum alanine aminotransferase in hepatitis C screening of patients with chronic renal failure on hemodialysis. Rev Soc Braz Med Trop 2004,37(1):18-21.

39.

Fabrizi F, Poordad F, Martin P: Hepatitis C infection and the patients with end-stage renal disease. Hepat 2002,36(1):3-10. 10.1053/jhep.2002.34613CrossRef

Title: Prevalence and risk factors of hepatitis B and C viruses among haemodialysis patients in Gaza strip, Palestine
Authors: Abed El-kader Y El-Ottol
Abdelraouf A Elmanama
Basim M Ayesh
Publication date: 01-12-2010
Publisher: BioMed Central
Published in: Virology Journal / Issue 1/2010
Electronic ISSN: 1743-422X
DOI: https://doi.org/10.1186/1743-422X-7-210

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