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Open Access 01-12-2011 | Hypothesis

Neuro-inflammation, blood-brain barrier, seizures and autism

Authors: Theoharis C Theoharides, Bodi Zhang

Published in: Journal of Neuroinflammation | Issue 1/2011

Abstract

Many children with Autism Spectrum Diseases (ASD) present with seizure activity, but the pathogenesis is not understood. Recent evidence indicates that neuro-inflammation could contribute to seizures. We hypothesize that brain mast cell activation due to allergic, environmental and/or stress triggers could lead to focal disruption of the blood-brain barrier and neuro-inflammation, thus contributing to the development of seizures. Treating neuro-inflammation may be useful when anti-seizure medications are ineffective.

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Title: Neuro-inflammation, blood-brain barrier, seizures and autism
Authors: Theoharis C Theoharides
Bodi Zhang
Publication date: 01-12-2011
Publisher: BioMed Central
Published in: Journal of Neuroinflammation / Issue 1/2011
Electronic ISSN: 1742-2094
DOI: https://doi.org/10.1186/1742-2094-8-168

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Neuro-inflammation, blood-brain barrier, seizures and autism

Abstract

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

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