Issue 1/2011
Content (187 Articles)
The mTOR kinase inhibitor rapamycin decreases iNOS mRNA stability in astrocytes
Lucia Lisi, Pierluigi Navarra, Douglas L Feinstein, Cinzia Dello Russo
Plasmacytoid dendritic cells are increased in cerebrospinal fluid of untreated patients during multiple sclerosis relapse
Ana Leda F Longhini, Felipe von Glehn, Carlos Otávio Brandão, Rosemeire FO de Paula, Fernando Pradella, Adriel S Moraes, Alessandro S Farias, Elaine C Oliveira, Juan G Quispe-Cabanillas, Cassiana Horta Abreu, Alfredo Damasceno, Benito P Damasceno, Konstantin E Balashov, Leonilda MB Santos
Microglial MAC1 receptor and PI3K are essential in mediating β-amyloid peptide-induced microglial activation and subsequent neurotoxicity
Dan Zhang, Xiaoming Hu, Li Qian, Shih-Heng Chen, Hui Zhou, Belinda Wilson, David S Miller, Jau-Shyong Hong
Contribution of complement activation pathways to neuropathology differs among mouse models of Alzheimer's disease
Maria I Fonseca, Shu-Hui Chu, Alisia M Berci, Marie E Benoit, Douglas G Peters, Yuko Kimura, Andrea J Tenner
Cannabidiol reduces lipopolysaccharide-induced vascular changes and inflammation in the mouse brain: an intravital microscopy study
Lourdes Ruiz-Valdepeñas, José A Martínez-Orgado, Cristina Benito, África Millán, Rosa M Tolón, Julián Romero
Inhibition of spinal astrocytic c-Jun N-terminal kinase (JNK) activation correlates with the analgesic effects of ketamine in neuropathic pain
Xiao-Peng Mei, Hui Zhang, Wei Wang, Yan-Yan Wei, Ming-Zhu Zhai, Wen Wang, Li-Xian Xu, Yun-Qing Li
Reduced spiral ganglion neuronal loss by adjunctive neurotrophin-3 in experimental pneumococcal meningitis
Cornelia Demel, Tobias Hoegen, Armin Giese, Barbara Angele, Hans-Walter Pfister, Uwe Koedel, Matthias Klein
Cooperative contributions of Interferon regulatory factor 1 (IRF1) and IRF8 to interferon-γ-mediated cytotoxic effects on oligodendroglial progenitor cells
Makoto Horiuchi, Aki Itoh, David Pleasure, Keiko Ozato, Takayuki Itoh
CX3CL1 reduces neurotoxicity and microglial activation in a rat model of Parkinson's disease
Mibel M Pabon, Adam D Bachstetter, Charles E Hudson, Carmelina Gemma, Paula C Bickford
Evidence for regulatory diversity and auto-regulation at the TAC1 locus in sensory neurones
Lynne Shanley, Marissa Lear, Scott Davidson, Ruth Ross, Alasdair MacKenzie
The formyl peptide receptor like-1 and scavenger receptor MARCO are involved in glial cell activation in bacterial meningitis
Benedikt J Braun, Alexander Slowik, Stephen L Leib, Ralph Lucius, Deike Varoga, Christoph J Wruck, Sandra Jansen, Rainer Podschun, Thomas Pufe, Lars-Ove Brandenburg
Central administration of insulin-like growth factor-I decreases depressive-like behavior and brain cytokine expression in mice
Sook-Eun Park, Robert Dantzer, Keith W Kelley, Robert H McCusker
Distribution of interleukin-1 receptor complex at the synaptic membrane driven by interleukin-1β and NMDA stimulation
Fabrizio Gardoni, Mariaserena Boraso, Elisa Zianni, Emanuela Corsini, Corrado L Galli, Flaminio Cattabeni, Marina Marinovich, Monica Di Luca, Barbara Viviani
Soybean-derived Bowman-Birk inhibitor inhibits neurotoxicity of LPS-activated macrophages
Jieliang Li, Li Ye, Denise R Cook, Xu Wang, Jinping Liu, Dennis L Kolson, Yuri Persidsky, Wen-Zhe Ho
SDF1 in the dorsal corticospinal tract promotes CXCR4+ cell migration after spinal cord injury
Vicki M Tysseling, Divakar Mithal, Vibhu Sahni, Derin Birch, Hosung Jung, Richard J Miller, John A Kessler
The relationship between indoleamine 2,3-dioxygenase activity and post-stroke cognitive impairment
Allison B Gold, Nathan Herrmann, Walter Swardfager, Sandra E Black, Richard I Aviv, Gayla Tennen, Alexander Kiss, Krista L Lanctôt
ErratumTo: Cerebral ischemia induces microvascular pro-inflammatory cytokine expression via the MEK/ERK pathway
Aida Maddahi, Lars Edvinsson
Deleterious effects of lymphocytes at the early stage of neurodegeneration in an animal model of amyotrophic lateral sclerosis
Satoru Tada, Tatsusada Okuno, Teruhito Yasui, Yuji Nakatsuji, Tomoyuki Sugimoto, Hitoshi Kikutani, Saburo Sakoda
Differential contribution of electrically evoked dorsal root reflexes to peripheral vasodilatation and plasma extravasation
Oleg V Lobanov, Yuan B Peng
Insulin-like growth factor-I gene delivery to astrocytes reduces their inflammatory response to lipopolysaccharide
Maria J Bellini, Claudia B Hereñú, Rodolfo G Goya, Luis M Garcia-Segura
Myelin down-regulates myelin phagocytosis by microglia and macrophages through interactions between CD47 on myelin and SIRPα (signal regulatory protein-α) on phagocytes
Miri Gitik, Sigal Liraz-Zaltsman, Per-Arne Oldenborg, Fanny Reichert, Shlomo Rotshenker
Signal pathways in astrocytes activated by cross-talk between of astrocytes and mast cells through CD40-CD40L
Dae Yong Kim, Gwan Ui Hong, Jai Youl Ro
Neurovascular dysfunction, inflammation and endothelial activation: Implications for the pathogenesis of Alzheimer's disease
Paula Grammas
Atorvastatin prevents age-related and amyloid-β-induced microglial activation by blocking interferon-γ release from natural killer cells in the brain
Anthony Lyons, Kevin J Murphy, Rachael Clarke, Marina A Lynch
Protein kinase C-α signals P115RhoGEF phosphorylation and RhoA activation in TNF-α-induced mouse brain microvascular endothelial cell barrier dysfunction
Jing Peng, Fang He, Ciliu Zhang, Xiaolu Deng, Fei Yin
Temporal profiles of age-dependent changes in cytokine mRNA expression and glial cell activation after status epilepticus in postnatal rat hippocampus
Juha T Järvelä, Francisco R Lopez-Picon, Anna Plysjuk, Saku Ruohonen, Irma E Holopainen
Expression of tumor necrosis factor-α and interleukin-1β genes in the cochlea and inferior colliculus in salicylate-induced tinnitus
Juen-Haur Hwang, Jin-Cherng Chen, Shan-Ying Yang, Ming-Fu Wang, Yin-Ching Chan
Erratum to: SDF1 in the dorsal corticospinal tract promotes CXCR4+ cell migration after spinal cord injury
Vicki M Tysseling, Divakar Mithal, Vibhu Sahni, Derin Birch, Hosung Jung, Abdelhak Belmadani, Richard J Miller, John A Kessler
Enhanced neuroinflammation and pain hypersensitivity after peripheral nerve injury in rats expressing mutated superoxide dismutase 1
Julie V Berger, Ronald Deumens, Stéphanie Goursaud, Sabrina Schäfer, Patricia Lavand'homme, Elbert A Joosten, Emmanuel Hermans
Overweight worsens apoptosis, neuroinflammation and blood-brain barrier damage after hypoxic ischemia in neonatal brain through JNK hyperactivation
Yi-Fang Tu, Yau-Sheng Tsai, Lan-Wan Wang, Hsin-Chieh Wu, Chao-Ching Huang, Chien-Jung Ho
Selective adenosine A2Areceptor agonists and antagonists protect against spinal cord injury through peripheral and central effects
Irene Paterniti, Alessia Melani, Sara Cipriani, Francesca Corti, Tommaso Mello, Emanuela Mazzon, Emanuela Esposito, Placido Bramanti, Salvatore Cuzzocrea, Felicita Pedata
The CCAAT/enhancer binding protein (C/EBP) δ is differently regulated by fibrillar and oligomeric forms of the Alzheimer amyloid-β peptide
Veronica Ramberg, Linda M Tracy, Malin Samuelsson, Lars NG Nilsson, Kerstin Iverfeldt
Pro-inflammatory gene expression in solid glioblastoma microenvironment and in hypoxic stem cells from human glioblastoma
Marco Tafani, Maura Di Vito, Alessandro Frati, Laura Pellegrini, Elena De Santis, Giovanni Sette, Adriana Eramo, Patrizio Sale, Emanuela Mari, Antonio Santoro, Antonino Raco, Maurizio Salvati, Ruggero De Maria, Matteo A Russo
Genomic profile of Toll-like receptor pathways in traumatically brain-injured mice: effect of exogenous progesterone
Fang Hua, Jun Wang, Tauheed Ishrat, Wenjing Wei, Fahim Atif, Iqbal Sayeed, Donald G Stein
MyD88 is pivotal for immune recognition of Citrobacter koseri and astrocyte activation during CNS infection†
Shuliang Liu, Tammy Kielian
Regulation of Toll-like receptor 1 and -2 in neonatal mice brains after hypoxia-ischemia
Linnea Stridh, Peter LP Smith, Andrew S Naylor, Xiaoyang Wang, Carina Mallard
Increased serum levels of anti-ganglioside M1 auto-antibodies in autistic children: relation to the disease severity
Gehan A Mostafa, Laila Y AL-ayadhi
Increased expression of the chemokines CXCL1 and MIP-1α by resident brain cells precedes neutrophil infiltration in the brain following prolonged soman-induced status epilepticus in rats
Erik A Johnson, Thuy L Dao, Michelle A Guignet, Claire E Geddes, Andrew I Koemeter-Cox, Robert K Kan
Expression of mutant alpha-synuclein modulates microglial phenotype in vitro
Lalida Rojanathammanee, Eric J Murphy, Colin K Combs
Indications of Th1 and Th17 responses in cerebrospinal fluid from patients with Lyme neuroborreliosis: a large retrospective study
Anna J Henningsson, Ivar Tjernberg, Bo-Eric Malmvall, Pia Forsberg, Jan Ernerudh
Specific PKC isoforms regulate LPS-stimulated iNOS induction in murine microglial cells
Jie Wen, Rachel Ribeiro, Yumin Zhang
Changes in interleukin-1 signal modulators induced by 3,4-methylenedioxymethamphetamine (MDMA): regulation by CB2 receptors and implications for neurotoxicity
Elisa Torres, Maria D Gutierrez-Lopez, Andrea Mayado, Ana Rubio, Esther O'Shea, Maria I Colado
Inhibition of interleukin-6 trans-signaling in the brain facilitates recovery from lipopolysaccharide-induced sickness behavior
Michael D Burton, Nathan L Sparkman, Rodney W Johnson
Mycobacterium tuberculosis-infected human monocytes down-regulate microglial MMP-2 secretion in CNS tuberculosis via TNFα, NFκB, p38 and caspase 8 dependent pathways
Justin A Green, Shruti Dholakia, Karolina Janczar, Catherine WM Ong, Rachel Moores, Julie Fry, Paul T Elkington, Federico Roncaroli, Jon S Friedland
IL-6 is increased in the cerebellum of autistic brain and alters neural cell adhesion, migration and synaptic formation
Hongen Wei, Hua Zou, Ashfaq M Sheikh, Mazhar Malik, Carl Dobkin, W Ted Brown, Xiaohong Li
Vascular endothelial growth factor-A (VEGF-A) and chemokine ligand-2 (CCL2) in amyotrophic lateral sclerosis (ALS) patients
Pawan K Gupta, Sudesh Prabhakar, Suresh Sharma, Akshay Anand
Increased expression of cystine/glutamate antiporter in multiple sclerosis
Olatz Pampliega, María Domercq, Federico N Soria, Pablo Villoslada, Alfredo Rodríguez-Antigüedad, Carlos Matute
Lentiviral vector-mediated stable expression of sTNFR-Fc in human macrophage and neuronal cells as a potential therapy for neuroAIDS
Shengbo Cao, Chengxiang Wu, Yongbo Yang, Lynn F Sniderhan, Sanjay B Maggirwar, Stephen Dewhurst, Yuanan Lu
Predominance of Th2 polarization by Vitamin D through a STAT6-dependent mechanism
Scott Sloka, Claudia Silva, Jianxiong Wang, V Wee Yong
Exogenous nitric oxide decreases brain vascular inflammation, leakage and venular resistance during Plasmodium berghei ANKA infection in mice
Graziela M Zanini, Pedro Cabrales, Wisam Barkho, John A Frangos, Leonardo JM Carvalho
Exacerbation of CNS inflammation and neurodegeneration by systemic LPS treatment is independent of circulating IL-1β and IL-6
Carol L Murray, Donal T Skelly, Colm Cunningham
The effects of high dose interferon-β1a on plasma microparticles: Correlation with MRI parameters
Mary Lowery-Nordberg, Erin Eaton, Eduardo Gonzalez-Toledo, Meghan K Harris, Kathrine Chalamidas, Jeanie McGee-Brown, Chaitanya V Ganta, Alireza Minagar, David Cousineau, J Steven Alexander
Loss of the receptor tyrosine kinase Axl leads to enhanced inflammation in the CNS and delayed removal of myelin debris during Experimental Autoimmune Encephalomyelitis
Jason G Weinger, Celia F Brosnan, Olivier Loudig, Michael F Goldberg, Fernando Macian, Heather A Arnett, Anne L Prieto, Vladislav Tsiperson, Bridget Shafit-Zagardo
Transcellular migration of neutrophil granulocytes through the blood-cerebrospinal fluid barrier after infection with Streptococcus suis
Corinna Wewer, Annette Seibt, Hartwig Wolburg, Lilo Greune, M Alexander Schmidt, Jürgen Berger, Hans-Joachim Galla, Ulrike Quitsch, Christian Schwerk, Horst Schroten, Tobias Tenenbaum
Developmental regulation of the neuroinflammatory responses to LPS and/or hypoxia-ischemia between preterm and term neonates: An experimental study
Marie-Elsa Brochu, Sylvie Girard, Karine Lavoie, Guillaume Sébire
A dual role for microglia in promoting tissue inhibitor of metalloproteinase (TIMP) expression in glial cells in response to neuroinflammatory stimuli
Jennifer V Welser-Alves, Stephen J Crocker, Richard Milner
Classically and alternatively activated bone marrow derived macrophages differ in cytoskeletal functions and migration towards specific CNS cell types
Elly JF Vereyken, Priscilla DAM Heijnen, Wia Baron, Elga HE de Vries, Christine D Dijkstra, Charlotte E Teunissen
P2X7 receptor activation ameliorates CA3 neuronal damage via a tumor necrosis factor-α-mediated pathway in the rat hippocampus following status epilepticus
Ji-Eun Kim, Hea Jin Ryu, Tae-Cheon Kang
Alteration of T cell cytokine production in PLPp-139-151-induced EAE in SJL mice by an immunostimulatory CpG Oligonucleotide
Vsevolod Smolianov, Thomas Dehmel, Patrick Vollmar, Anne K Mausberg, Bernd C Kieseier, Bernhard Hemmer, Hans P Hartung, Harald H Hofstetter
Mild hypothermia causes differential, time-dependent changes in cytokine expression and gliosis following endothelin-1-induced transient focal cerebral ischemia
An-Gaëlle Ceulemans, Tine Zgavc, Ron Kooijman, Said Hachimi-Idrissi, Sophie Sarre, Yvette Michotte
Sesamin ameliorates oxidative stress and mortality in kainic acid-induced status epilepticus by inhibition of MAPK and COX-2 activation
Peiyuan F Hsieh, Chien-Wei Hou, Pei-Wun Yao, Szu-Pei Wu, Yu-Fen Peng, Mei-Lin Shen, Ching-Huei Lin, Ya-Yun Chao, Ming-Hong Chang, Kee-Ching Jeng
Momordica charantia (bitter melon) attenuates high-fat diet-associated oxidative stress and neuroinflammation
Pratibha V Nerurkar, Lisa M Johns, Lance M Buesa, Gideon Kipyakwai, Esther Volper, Ryuei Sato, Pranjal Shah, Domonkos Feher, Philip G Williams, Vivek R Nerurkar
Increased cerebral (R)-[11C]PK11195 uptake and glutamate release in a rat model of traumatic brain injury: a longitudinal pilot study
Hedy Folkersma, Jessica C Foster Dingley, Bart NM van Berckel, Annemieke Rozemuller, Ronald Boellaard, Marc C Huisman, Adriaan A Lammertsma, W Peter Vandertop, Carla FM Molthoff
Midazolam suppresses interleukin-1β-induced interleukin-6 release from rat glial cells
Kumiko Tanabe, Osamu Kozawa, Hiroki Iida
Temporal and sequential changes of glial cells and cytokine expression during neuronal degeneration after transient global ischemia in rats
Y Yasuda, T Shimoda, K Uno, N Tateishi, S Furuya, Y Tsuchihashi, Y Kawai, S Naruse, S Fujita
Prevention of the β-amyloid peptide-induced inflammatory process by inhibition of double-stranded RNA-dependent protein kinase in primary murine mixed co-cultures
J Couturier, M Paccalin, M Morel, F Terro, S Milin, R Pontcharraud, B Fauconneau, G Page
Loss of function mutations in the progranulin gene are related to pro-inflammatory cytokine dysregulation in frontotemporal lobar degeneration patients
Paola Bossù, Francesca Salani, Antonella Alberici, Silvana Archetti, Giuseppe Bellelli, Daniela Galimberti, Elio Scarpini, Gianfranco Spalletta, Carlo Caltagirone, Alessandro Padovani, Barbara Borroni
Melittin restores proteasome function in an animal model of ALS
Eun Jin Yang, Seon Hwy Kim, Sun Choel Yang, Sang Min Lee, Sun-Mi Choi
A lack of association between hyperserotonemia and the increased frequency of serum anti-myelin basic protein auto-antibodies in autistic children
Gehan Ahmed Mostafa, Laila Yousef AL-Ayadhi
Increased local concentration of complement C5a contributes to incisional pain in mice
Jun H Jang, Deyong Liang, Kanta Kido, Yuan Sun, David J Clark, Timothy J Brennan
Microglial p38α MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aβ)
Adam D Bachstetter, Bin Xing, Lucia de Almeida, Edgardo R Dimayuga, D Martin Watterson, Linda J Van Eldik
Granulocyte colony stimulating factor attenuates inflammation in a mouse model of amyotrophic lateral sclerosis
Eveliina Pollari, Ekaterina Savchenko, Merja Jaronen, Katja Kanninen, Tarja Malm, Sara Wojciechowski, Toni Ahtoniemi, Gundars Goldsteins, Raisa Giniatullina, Rashid Giniatullin, Jari Koistinaho, Johanna Magga
CCL2/MCP-1 modulation of microglial activation and proliferation
Ara E Hinojosa, Borja Garcia-Bueno, Juan C Leza, Jose LM Madrigal
Myelin-phagocytosing macrophages modulate autoreactive T cell proliferation
Jeroen FJ Bogie, Piet Stinissen, Niels Hellings, Jerome JA Hendriks
Lack of macrophage migration inhibitory factor in mice does not affect hallmarks of the inflammatory/immune response during the first week after stroke
Ana R Inácio, Richard Bucala, Tomas Deierborg
Fingolimod modulates microglial activation to augment markers of remyelination
Samuel J Jackson, Gavin Giovannoni, David Baker
S-Nitrosoglutathione reduces oxidative injury and promotes mechanisms of neurorepair following traumatic brain injury in rats
Mushfiquddin Khan, Harutoshi Sakakima, Tajinder S Dhammu, Anandakumar Shunmugavel, Yeong-Bin Im, Anne G Gilg, Avtar K Singh, Inderjit Singh
Neuroinflammation induces glial aromatase expression in the uninjured songbird brain
Kelli A Duncan, Colin J Saldanha
Lymph node-derived donor encephalitogenic CD4+T cells in C57BL/6 mice adoptive transfer experimental autoimmune encephalomyelitis highly express GM-CSF and T-bet
Petra D Cravens, Rehana Z Hussain, Tresa E Zacharias, Li-Hong Ben, Emily Herndon, Ramya Vinnakota, Doris Lambracht-Washington, Stefan Nessler, Scott S Zamvil, Todd N Eagar, Olaf Stüve
Estrogens regulate neuroinflammatory genes via estrogen receptors α and β in the frontal cortex of middle-aged female rats
Miklós Sárvári, Erik Hrabovszky, Imre Kalló, Norbert Solymosi, Kinga Tóth, István Likó, János Széles, Sándor Mahó, Béla Molnár, Zsolt Liposits
Heteroarylketones inhibit astroglial interleukin-6 expression via a STAT3/NF-κB signaling pathway
Ingo Schulz, Claudia Engel, André J Niestroj, Ulrike Zeitschel, Katja Menge, Astrid Kehlen, Antje Meyer, Steffen Roßner, Hans-Ulrich Demuth
A role for tumor necrosis factor-α in ischemia and ischemic preconditioning
Orla Watters, John J O'Connor
HIV-1 Tat activates indoleamine 2,3 dioxygenase in murine organotypic hippocampal slice cultures in a p38 mitogen-activated protein kinase-dependent manner
Xin Fu, Marcus A Lawson, Keith W Kelley, Robert Dantzer
Poly(I:C) promotes TNFα/TNFR1-dependent oligodendrocyte death in mixed glial cultures
Andrew J Steelman, Jianrong Li
ELISA measurement of specific non-antigen-bound antibodies to Aβ1-42 monomer and soluble oligomers in sera from Alzheimer's disease, mild cognitively impaired, and noncognitively impaired subjects
Andrea C Klaver, Mary P Coffey, Lynnae M Smith, David A Bennett, John M Finke, Loan Dang, David A Loeffler
Aspirin-triggered lipoxin A4attenuates LPS-induced pro-inflammatory responses by inhibiting activation of NF-κB and MAPKs in BV-2 microglial cells
Yan-Ping Wang, Yan Wu, Long-Yan Li, Jin Zheng, Ren-Gang Liu, Jie-Ping Zhou, Shi-Ying Yuan, You Shang, Shang-Long Yao
Transcriptional analysis of rat piriform cortex following exposure to the organophosphonate anticholinesterase sarin and induction of seizures
Kimberly D Spradling, Lucille A Lumley, Christopher L Robison, James L Meyerhoff, James F Dillman III
Erratum to: Vascular endothelial growth factor-A (VEGF-A) and chemokine ligand-2 (CCL2) in amyotrophic lateral sclerosis (ALS) patients
Pawan K Gupta, Sudesh Prabhakar, Suresh Sharma, Akshay Anand
Alzheimer's disease - a neurospirochetosis. Analysis of the evidence following Koch's and Hill's criteria
Judith Miklossy
The PPAR-γ agonist pioglitazone modulates inflammation and induces neuroprotection in parkinsonian monkeys
Christine R Swanson, Valerie Joers, Viktoriya Bondarenko, Kevin Brunner, Heather A Simmons, Toni E Ziegler, Joseph W Kemnitz, Jeffrey A Johnson, Marina E Emborg
TLR4 mutation reduces microglial activation, increases Aβ deposits and exacerbates cognitive deficits in a mouse model of Alzheimer's disease
Min Song, JingJi Jin, Jeong-Eun Lim, Jinghong Kou, Abhinandan Pattanayak, Jamaal A Rehman, Hong-Duck Kim, Kazuki Tahara, Robert Lalonde, Ken-ichiro Fukuchi
CRP gene variation affects early development of Alzheimer's disease-related plaques
Eloise Helena Kok, Mervi Alanne-Kinnunen, Karita Isotalo, Teemu Luoto, Satu Haikonen, Sirkka Goebeler, Markus Perola, Mikko A Hurme, Hannu Haapasalo, Pekka J Karhunen
Methyl salicylate 2-O-β- D -lactoside, a novel salicylic acid analogue, acts as an anti-inflammatory agent on microglia and astrocytes
Xi Lan, Rui Liu, Lan Sun, Tiantai Zhang, Guanhua Du
A role for DNA-dependent activator of interferon regulatory factor in the recognition of herpes simplex virus type 1 by glial cells
Samantha R Furr, Vinita S Chauhan, Megan J Moerdyk-Schauwecker, Ian Marriott
Peripheral anti-inflammatory effects explain the ginsenosides paradox between poor brain distribution and anti-depression efficacy
An Kang, Haiping Hao, Xiao Zheng, Yan Liang, Yuan Xie, Tong Xie, Chen Dai, Qijin Zhao, Xiaolan Wu, Lin Xie, Guangji Wang
Reduction of neutrophil activity decreases early microvascular injury after subarachnoid haemorrhage
Victor Friedrich, Rowena Flores, Artur Muller, Weina Bi, Ellinor IB Peerschke, Fatima A Sehba
Anandamide inhibits Theiler's virus induced VCAM-1 in brain endothelial cells and reduces leukocyte transmigration in a model of blood brain barrier by activation of CB1receptors
Leyre Mestre, Paula M Iñigo, Miriam Mecha, Fernando G Correa, Miriam Hernangómez-Herrero, Frida Loría, Fabian Docagne, José Borrell, Carmen Guaza
Cigarette smoke extract upregulates heme oxygenase-1 via PKC/NADPH oxidase/ROS/PDGFR/PI3K/Akt pathway in mouse brain endothelial cells
Ruey-Horng Shih, Shin-Ei Cheng, Li-Der Hsiao, Yu Ru Kou, Chuen-Mao Yang
RETRACTED ARTICLE: Increased neuroinflammatory and arachidonic acid cascade markers, and reduced synaptic proteins, in brain of HIV-1 transgenic rats
Jagadeesh Sridhara Rao, Hyung-Wook Kim, Matthew Kellom, Dede Greenstein, Mei Chen, Andrew David Kraft, Gaylia Jean Harry, Stanley Isaac Rapoport, Mireille Basselin
Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: Evidence for an immune-modulated glutamatergic neurotransmission?
Johann Steiner, Martin Walter, Tomasz Gos, Gilles J Guillemin, Hans-Gert Bernstein, Zoltán Sarnyai, Christian Mawrin, Ralf Brisch, Hendrik Bielau, Louise Meyer zu Schwabedissen, Bernhard Bogerts, Aye-Mu Myint
The role of tumor necrosis factor-α and TNF-α receptors in cerebral arteries following cerebral ischemia in rat
Aida Maddahi, Lars S Kruse, Qing-Wen Chen, Lars Edvinsson
Wallerian degeneration: the innate-immune response to traumatic nerve injury
Shlomo Rotshenker
Nogo receptor is involved in the adhesion of dendritic cells to myelin
Claire L McDonald, Karin Steinbach, Florian Kern, Rüdiger Schweigreiter, Roland Martin, Christine E Bandtlow, Markus Reindl
Vascular endothelial growth factor-A and chemokine ligand (CCL2) genes are upregulated in peripheral blood mononuclear cells in Indian amyotrophic lateral sclerosis patients
Pawan K Gupta, Sudesh Prabhakar, Chandrika Abburi, Neel K Sharma, Akshay Anand
Osteoarthritis accelerates and exacerbates Alzheimer's disease pathology in mice
Stephanos Kyrkanides, Ross H Tallents, Jen-nie H Miller, Mallory E Olschowka, Renee Johnson, Meixiang Yang, John A Olschowka, Sabine M Brouxhon, M Kerry O'Banion
Transcriptional responses of the nerve agent-sensitive brain regions amygdala, hippocampus, piriform cortex, septum, and thalamus following exposure to the organophosphonate anticholinesterase sarin
Kimberly D Spradling, Lucille A Lumley, Christopher L Robison, James L Meyerhoff, James F Dillman III
Tissue inhibitor of metalloproteinases-3 mediates the death of immature oligodendrocytes via TNF-α/TACE in focal cerebral ischemia in mice
Yi Yang, Fakhreya Y Jalal, Jeffrey F Thompson, Espen J Walker, Eduardo Candelario-Jalil, Lu Li, Ross R Reichard, Chi Ben, Qing-Xiang Sang, Lee Anna Cunningham, Gary A Rosenberg
Wallerian degeneration: gaining perspective on inflammatory events after peripheral nerve injury
Andrew D Gaudet, Phillip G Popovich, Matt S Ramer
Brain pericytes among cells constituting the blood-brain barrier are highly sensitive to tumor necrosis factor-α, releasing matrix metalloproteinase-9 and migrating in vitro
Fuyuko Takata, Shinya Dohgu, Junichi Matsumoto, Hiroyuki Takahashi, Takashi Machida, Tomoya Wakigawa, Eriko Harada, Haruki Miyaji, Mitsuhisa Koga, Tsuyoshi Nishioku, Atsushi Yamauchi, Yasufumi Kataoka
Low plasma progranulin levels in children with autism
Laila Y AL-Ayadhi, Gehan A Mostafa
Activation of matrix metalloproteinases following anti-Aβ immunotherapy; implications for microhemorrhage occurrence
Donna M Wilcock, Dave Morgan, Marcia N Gordon, Tiffany L Taylor, Lisa A Ridnour, David A Wink, Carol A Colton
Sinomenine inhibits microglial activation by Aβ and confers neuroprotection
Shilpa Mishra Shukla, Shiv K Sharma
Air pollution & the brain: Subchronic diesel exhaust exposure causes neuroinflammation and elevates early markers of neurodegenerative disease
Shannon Levesque, Michael J Surace, Jacob McDonald, Michelle L Block
Cerebral amyloid angiopathy-related inflammation presenting with steroid-responsive higher brain dysfunction: case report and review of the literature
Hideya Sakaguchi, Akihiko Ueda, Takayuki Kosaka, Satoshi Yamashita, En Kimura, Taro Yamashita, Yasushi Maeda, Teruyuki Hirano, Makoto Uchino
Activation of retinal microglia rather than microglial cell density correlates with retinal neovascularization in the mouse model of oxygen-induced retinopathy
Franziska Fischer, Gottfried Martin, Hansjürgen T Agostini
Treatment with gelsolin reduces brain inflammation and apoptotic signaling in mice following thermal injury
Qing-Hong Zhang, Qi Chen, Jia-Rui Kang, Chen Liu, Ning Dong, Xiao-Mei Zhu, Zhi-Yong Sheng, Yong-Ming Yao
Strain-dependent variation in the early transcriptional response to CNS injury using a cortical explant system
David J Graber, Brent T Harris, William F Hickey
Curcumin is a potent modulator of microglial gene expression and migration
Marcus Karlstetter, Elena Lippe, Yana Walczak, Christoph Moehle, Alexander Aslanidis, Myriam Mirza, Thomas Langmann
Reactive oxygen species drive herpes simplex virus (HSV)-1-induced proinflammatory cytokine production by murine microglia
Shuxian Hu, Wen S Sheng, Scott J Schachtele, James R Lokensgard
Lipocalin 2 in the central nervous system host response to systemic lipopolysaccharide administration
Jacque PK Ip, Aline L Noçon, Markus J Hofer, Sue Ling Lim, Marcus Müller, Iain L Campbell
Lipopolysaccharide modulates astrocytic S100B secretion: a study in cerebrospinal fluid and astrocyte cultures from rats
Maria Cristina Guerra, Lucas S Tortorelli, Fabiana Galland, Carollina Da Ré, Elisa Negri, Douglas S Engelke, Letícia Rodrigues, Marina C Leite, Carlos-Alberto Gonçalves
Generation of reactive oxygen species in 1-methyl-4-phenylpyridinium (MPP+) treated dopaminergic neurons occurs as an NADPH oxidase-dependent two-wave cascade
W Michael Zawada, Gregg P Banninger, Jennifer Thornton, Beth Marriott, David Cantu, Angela L Rachubinski, Mita Das, W Sue T Griffin, Susan M Jones
Delayed inflammatory mRNA and protein expression after spinal cord injury
Kimberly R Byrnes, Patricia M Washington, Susan M Knoblach, Eric Hoffman, Alan I Faden
Toll-like receptors in cerebral ischemic inflammatory injury
Yan-Chun Wang, Sen Lin, Qing-Wu Yang
Up-regulation of dorsal root ganglia BDNF and trkB receptor in inflammatory pain: an in vivo and in vitrostudy
Ya-Tin Lin, Long-Sun Ro, Hung-Li Wang, Jin-Chung Chen
Toll-like receptor 2 -196 to -174 del polymorphism influences the susceptibility of Han Chinese people to Alzheimer's disease
Jin-Tai Yu, Shan-Mao Mou, Li-Zhu Wang, Cai-Xia Mao, Lan Tan
The role of the MYD88-dependent pathway in MPTP-induced brain dopaminergic degeneration
Janelle Drouin-Ouellet, Claire Gibrat, Mélanie Bousquet, Frédéric Calon, Jasna Kriz, Francesca Cicchetti
Pro-inflammatory cytokines and lipopolysaccharide induce changes in cell morphology, and upregulation of ERK1/2, iNOS and sPLA2-IIA expression in astrocytes and microglia
Wenwen Sheng, Yijia Zong, Arwa Mohammad, Deepa Ajit, Jiankun Cui, Dongdong Han, Jennifer L Hamilton, Agnes Simonyi, Albert Y Sun, Zezong Gu, Jau-Shyong Hong, Gary A Weisman, Grace Y Sun
In vivo imaging of lymphocytes in the CNS reveals different behaviour of naïve T cells in health and autoimmunity
Josephine Herz, Magdalena Paterka, Raluca A Niesner, Alexander U Brandt, Volker Siffrin, Tina Leuenberger, Jerome Birkenstock, Agata Mossakowski, Robert Glumm, Frauke Zipp, Helena Radbruch
Overexpression of serine racemase in retina and overproduction of D-serine in eyes of streptozotocin-induced diabetic retinopathy
Haiyan Jiang, Junxu Fang, Bo Wu, Guibin Yin, Lin Sun, Jia Qu, Steven W Barger, Shengzhou Wu
Inhibitory effect of a tyrosine-fructose Maillard reaction product, 2,4-bis(p-hydroxyphenyl)-2-butenal on amyloid-β generation and inflammatory reactions via inhibition of NF-κB and STAT3 activation in cultured astrocytes and microglial BV-2 cells
Young-Jung Lee, Dong-Young Choi, Im Seup Choi, Jin-Yi Han, Heon-Sang Jeong, Sang Bae Han, Ki-Wan Oh, Jin Tae Hong
Brain microvascular pericytes are immunoactive in culture: cytokine, chemokine, nitric oxide, and LRP-1 expression in response to lipopolysaccharide
Andrej Kovac, Michelle A Erickson, William A Banks
Increased levels of HMGB1 and pro-inflammatory cytokines in children with febrile seizures
Jieun Choi, Hyun Jin Min, Jeon-Soo Shin
Cautionary notes on the use of NF-κB p65 and p50 antibodies for CNS studies
Miles Herkenham, Priyanka Rathore, Pierre Brown, Samuel J Listwak
Proinflammatory and proapoptotic markers in relation to mono and di-cations in plasma of autistic patients from Saudi Arabia
Afaf K El-Ansary, Abir G Ben Bacha, Laila Y Al-Ayadhi
Concurrent hippocampal induction of MHC II pathway components and glial activation with advanced aging is not correlated with cognitive impairment
Heather D VanGuilder, Georgina V Bixler, Robert M Brucklacher, Julie A Farley, Han Yan, Junie P Warrington, William E Sonntag, Willard M Freeman
Anti-CD20 B-cell depletion enhances monocyte reactivity in neuroimmunological disorders
Klaus Lehmann-Horn, Eva Schleich, Deetje Hertzenberg, Alexander Hapfelmeier, Tania Kümpfel, Nikolas von Bubnoff, Reinhard Hohlfeld, Achim Berthele, Bernhard Hemmer, Martin S Weber
Post-traumatic hypoxia exacerbates neurological deficit, neuroinflammation and cerebral metabolism in rats with diffuse traumatic brain injury
Edwin B Yan, Sarah C Hellewell, Bo-Michael Bellander, Doreen A Agyapomaa, M Cristina Morganti-Kossmann
Oral administration of the KATP channel opener diazoxide ameliorates disease progression in a murine model of multiple sclerosis
Noemí Virgili, Juan F Espinosa-Parrilla, Pilar Mancera, Andrea Pastén-Zamorano, Javier Gimeno-Bayon, Manuel J Rodríguez, Nicole Mahy, Marco Pugliese
The contribution of activated astrocytes to Aβ production: Implications for Alzheimer's disease pathogenesis
Jie Zhao, Tracy O'Connor, Robert Vassar
LPS preconditioning redirects TLR signaling following stroke: TRIF-IRF3 plays a seminal role in mediating tolerance to ischemic injury
Keri B Vartanian, Susan L Stevens, Brenda J Marsh, Rebecca Williams-Karnesky, Nikola S Lessov, Mary P Stenzel-Poore
Origin and consequences of brain Toll-like receptor 4 pathway stimulation in an experimental model of depression
Iciar Gárate, Borja García-Bueno, José LM Madrigal, Lidia Bravo, Esther Berrocoso, Javier R Caso, Juan A Micó, Juan C Leza
Differential aquaporin 4 expression during edema build-up and resolution phases of brain inflammation
Thomas Tourdias, Nobuyuki Mori, Iulus Dragonu, Nadège Cassagno, Claudine Boiziau, Justine Aussudre, Bruno Brochet, Chrit Moonen, Klaus G Petry, Vincent Dousset
Pro-inflammatory gene expression and neurotoxic effects of activated microglia are attenuated by absence of CCAAT/enhancer binding protein β
Marco Straccia, Núria Gresa-Arribas, Guido Dentesano, Aroa Ejarque-Ortiz, Josep M Tusell, Joan Serratosa, Carme Solà, Josep Saura
CD200-CD200R dysfunction exacerbates microglial activation and dopaminergic neurodegeneration in a rat model of Parkinson's disease
Shi Zhang, Xi-Jin Wang, Li-Peng Tian, Jing Pan, Guo-Qiang Lu, Ying-Jie Zhang, Jian-Qing Ding, Sheng-Di Chen
Serum lipid profiles are associated with disability and MRI outcomes in multiple sclerosis
Bianca Weinstock-Guttman, Robert Zivadinov, Naeem Mahfooz, Ellen Carl, Allison Drake, Jaclyn Schneider, Barbara Teter, Sara Hussein, Bijal Mehta, Marc Weiskopf, Jacqueline Durfee, Niels Bergsland, Murali Ramanathan
Comparing the immunosuppressive potency of naïve marrow stromal cells and Notch-transfected marrow stromal cells
Mo A Dao, Ciara C Tate, Irina Aizman, Michael McGrogan, Casey C Case
Human brain endothelial cells endeavor to immunoregulate CD8 T cells via PD-1 ligand expression in multiple sclerosis
Camille L Pittet, Jia Newcombe, Alexandre Prat, Nathalie Arbour
Reduced inflammation accompanies diminished myelin damage and repair in the NG2 null mouse spinal cord
Karolina Kucharova, Yunchao Chang, Andrej Boor, Voon Wee Yong, William B Stallcup
Lateral fluid percussion injury of the brain induces CCL20 inflammatory chemokine expression in rats
Mahasweta Das, Christopher C Leonardo, Saniya Rangooni, Keith R Pennypacker, Subhra Mohapatra, Shyam S Mohapatra
Chitotriosidase as a biomarker of cerebral adrenoleukodystrophy
Paul J Orchard, Troy Lund, Wes Miller, Steven M Rothman, Gerald Raymond, David Nascene, Lisa Basso, James Cloyd, Jakub Tolar
Systemic inflammatory challenges compromise survival after experimental stroke via augmenting brain inflammation, blood- brain barrier damage and brain oedema independently of infarct size
Ádám Dénes, Szilamér Ferenczi, Krisztina J Kovács
Microglia use multiple mechanisms to mediate interactions with vitronectin; non-essential roles for the highly-expressed αvβ3 and αvβ5 integrins
Jennifer V Welser-Alves, Amin Boroujerdi, Ulrich Tigges, Richard Milner
Conformational epitopes of myelin oligodendrocyte glycoprotein are targets of potentially pathogenic antibody responses in multiple sclerosis
Til Menge, Patrice H Lalive, H-Christian von Büdingen, Claude P Genain
The acute inflammatory response to intranigral α-synuclein differs significantly from intranigral lipopolysaccharide and is exacerbated by peripheral inflammation
Yvonne Couch, Lydia Alvarez-Erviti, Nicola R Sibson, Matthew JA Wood, Daniel C Anthony
Neuropeptide Y inhibits interleukin-1β-induced phagocytosis by microglial cells
Raquel Ferreira, Tiago Santos, Michelle Viegas, Luísa Cortes, Liliana Bernardino, Otília V Vieira, João O Malva
HIV-1 and IL-1β regulate astrocytic CD38 through mitogen-activated protein kinases and nuclear factor-κB signaling mechanisms
Manmeet K Mamik, Sugato Banerjee, Timothy F Walseth, Renee Hirte, Lin Tang, Kathleen Borgmann, Anuja Ghorpade
Differential regional expression patterns of α-synuclein, TNF-α, and IL-1β; and variable status of dopaminergic neurotoxicity in mouse brain after Paraquat treatment
Soham Mitra, Nilkanta Chakrabarti, Arindam Bhattacharyya
Poly(ADP-ribose)polymerase-1 modulates microglial responses to amyloid β
Tiina M Kauppinen, Sang Won Suh, Youichirou Higashi, Ari E Berman, Carole Escartin, Seok Joon Won, Chao Wang, Seo-Hyun Cho, Li Gan, Raymond A Swanson
Gliovascular and cytokine interactions modulate brain endothelial barrier in vitro
Ganta V Chaitanya, Walter E Cromer, Shannon R Wells, Merilyn H Jennings, P Olivier Couraud, Ignacio A Romero, Babette Weksler, Anat Erdreich-Epstein, J Michael Mathis, Alireza Minagar, J Steven Alexander
Neuroinflammation in Alzheimer's disease wanes with age
Jeroen JM Hoozemans, Annemieke JM Rozemuller, Elise S van Haastert, Piet Eikelenboom, Willem A van Gool
Increased circulating leukocyte numbers and altered macrophage phenotype correlate with the altered immune response to brain injury in metallothionein (MT) -I/II null mutant mice
Michael W Pankhurst, William Bennett, Matthew TK Kirkcaldie, Adrian K West, Roger S Chung
Adaptive Müller cell responses to microglial activation mediate neuroprotection and coordinate inflammation in the retina
Minhua Wang, Wenxin Ma, Lian Zhao, Robert N Fariss, Wai T Wong
Temporal pattern of expression and colocalization of microglia/macrophage phenotype markers following brain ischemic injury in mice
Carlo Perego, Stefano Fumagalli, Maria-Grazia De Simoni
Peripheral leukocyte counts and outcomes after intracerebral hemorrhage
Shruti Agnihotri, Alexandra Czap, Ilene Staff, Gil Fortunato, Louise D McCullough
Neuroimmune modulation following traumatic stress in rats: evidence for an immunoregulatory cascade mediated by c-Src, miRNA222 and PAK1
Hui Zhao, Ranran Yao, Xiaoding Cao, Gencheng Wu
Interleukin-1α expression precedes IL-1β after ischemic brain injury and is localised to areas of focal neuronal loss and penumbral tissues
Nadia M Luheshi, Krisztina J Kovács, Gloria Lopez-Castejon, David Brough, Adam Denes
Interferon regulatory factor 3 plays an anti-inflammatory role in microglia by activating the PI3K/Akt pathway
Leonid Tarassishin, Hyeon-Sook Suh, Sunhee C Lee
Lipopolysaccharide-enhanced transcellular transport of HIV-1 across the blood-brain barrier is mediated by luminal microvessel IL-6 and GM-CSF
Shinya Dohgu, Melissa A Fleegal-DeMotta, William A Banks
Interferon regulatory factor-7 modulates experimental autoimmune encephalomyelitis in mice
Mohammad Salem, Jyothi T Mony, Morten Løbner, Reza Khorooshi, Trevor Owens
Participation of MCP-induced protein 1 in lipopolysaccharide preconditioning-induced ischemic stroke tolerance by regulating the expression of proinflammatory cytokines
Jian Liang, Jing Wang, Yasser Saad, Logan Warble, Edilu Becerra, Pappachan E Kolattukudy
The possible link between the elevated serum levels of neurokinin A and anti-ribosomal P protein antibodies in children with autism
Gehan A Mostafa, Laila Y AL-Ayadhi
Neuroprotective response after photodynamic therapy: Role of vascular endothelial growth factor
Misa Suzuki, Yoko Ozawa, Shunsuke Kubota, Manabu Hirasawa, Seiji Miyake, Kousuke Noda, Kazuo Tsubota, Kazuaki Kadonosono, Susumu Ishida
Modulation of spinal cord synaptic activity by tumor necrosis factor α in a model of peripheral neuropathy
Diana Spicarova, Vladimir Nerandzic, Jiri Palecek
Insulin-like growth factor-I peptides act centrally to decrease depression-like behavior of mice treated intraperitoneally with lipopolysaccharide
Sook-Eun Park, Marcus Lawson, Robert Dantzer, Keith W Kelley, Robert H McCusker
Effects of betaine on lipopolysaccharide-induced memory impairment in mice and the involvement of GABA transporter 2
Masaya Miwa, Mizuki Tsuboi, Yumiko Noguchi, Aoi Enokishima, Toshitaka Nabeshima, Masayuki Hiramatsu
Interleukin-1 beta and neurotrophin-3 synergistically promote neurite growth in vitro
Francesco Boato, Daniel Hechler, Karen Rosenberger, Doreen Lüdecke, Eva M Peters, Robert Nitsch, Sven Hendrix
Complement activating antibodies to myelin oligodendrocyte glycoprotein in neuromyelitis optica and related disorders
Simone Mader, Viktoria Gredler, Kathrin Schanda, Kevin Rostasy, Irena Dujmovic, Kristian Pfaller, Andreas Lutterotti, Sven Jarius, Franziska Di Pauli, Bettina Kuenz, Rainer Ehling, Harald Hegen, Florian Deisenhammer, Fahmy Aboul-Enein, Maria K Storch, Peter Koson, Jelena Drulovic, Wolfgang Kristoferitsch, Thomas Berger, Markus Reindl
Increased interleukin-1β levels following low dose MDMA induces tolerance against the 5-HT neurotoxicity produced by challenge MDMA
Andrea Mayado, Elisa Torres, Maria D Gutierrez-Lopez, Maria I Colado, Esther O'Shea
Low ficolin-3 levels in early follow-up serum samples are associated with the severity and unfavorable outcome of acute ischemic stroke
George Füst, Lea Munthe-Fog, Zsolt Illes, Gábor Széplaki, Tihamér Molnar, Gabriella Pusch, Kristóf Hirschberg, Robert Szegedi, Zoltán Széplaki, Zoltán Prohászka, Mikkel-Ole Skjoedt, Peter Garred
Apolipoprotein E expression is elevated by interleukin 1 and other interleukin 1-induced factors
Ling Liu, Orwa Aboud, Richard A Jones, Robert E Mrak, W Sue T Griffin, Steven W Barger
Neuro-inflammation, blood-brain barrier, seizures and autism
Theoharis C Theoharides, Bodi Zhang
TLR3 signaling is either protective or pathogenic for the development of Theiler's virus-induced demyelinating disease depending on the time of viral infection
Young-Hee Jin, Tomoki Kaneyama, Min Hyung Kang, Hyun Seok Kang, Chang-Sung Koh, Byung S Kim
CXCR7 antagonism prevents axonal injury during experimental autoimmune encephalomyelitis as revealed by in vivoaxial diffusivity
Lillian Cruz-Orengo, Ying-Jr Chen, Joong Hee Kim, Denise Dorsey, Sheng-Kwei Song, Robyn S Klein
Expression of sphingosine kinase 1 in amoeboid microglial cells in the corpus callosum of postnatal rats
Haiyan Lin, Nimmi Baby, Jia Lu, Charanjit Kaur, Chuansen Zhang, Jiajun Xu, Eng-Ang Ling, S Thameem Dheen
Expression and cellular localization of cyclooxygenases and prostaglandin E synthases in the hemorrhagic brain
Tao Wu, He Wu, Jessica Wang, Jian Wang
Intracerebral infection with dengue-3 virus induces meningoencephalitis and behavioral changes that precede lethality in mice
Debora CG Amaral, Milene A Rachid, Marcia C Vilela, Roberta DL Campos, Gustavo P Ferreira, David H Rodrigues, Norinne Lacerda-Queiroz, Aline S Miranda, Vivian V Costa, Marco A Campos, Erna G Kroon, Mauro M Teixeira, Antonio L Teixeira