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Open Access 01-12-2013 | Case report

Resolution of left atrial appendage thrombus with apixaban

Authors: Tohru Kawakami, Hiroko Kobayakawa, Hiroyoshi Ohno, Nobukiyo Tanaka, Hiroki Ishihara

Published in: Thrombosis Journal | Issue 1/2013

Abstract

Left atrial appendage (LAA) thrombosis is an important cause of cardiogenic cerebral thromboembolism. Apixaban is a member of the class of novel oral anticoagulants (NOAC) and is superior to warfarin in preventing stroke or systemic embolism, causes less bleeding, and results in lower mortality in patients with atrial fibrillation. There are few reports of resolution of LAA thrombus with other NOAC. We present a 72-year-old male patient with persistent atrial fibrillation associated with left atrial thrombus. Sixteen days of apixaban treatment showed complete thrombus resolution. In this study, soluble fibrin and D-dimer levels decreased without prolongation of international normalized ratio (INR) and activated partial thromboplastin time (APTT).

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Title: Resolution of left atrial appendage thrombus with apixaban
Authors: Tohru Kawakami
Hiroko Kobayakawa
Hiroyoshi Ohno
Nobukiyo Tanaka
Hiroki Ishihara
Publication date: 01-12-2013
Publisher: BioMed Central
Published in: Thrombosis Journal / Issue 1/2013
Electronic ISSN: 1477-9560
DOI: https://doi.org/10.1186/1477-9560-11-26

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